- Basic information
- CohesinDB ID: CDBP00415733
- Locus: chr21-27480366-27481430
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Data sourse: GSE206145, GSE85526, GSE206145-NatGen2015, GSE68388, GSE165895
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Cell type: RPE, Fibroblast, HEKn, HuCC-T1, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 5% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
36% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 76%,
"7_Enh": 13%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, FOXO1, PGR, SMC1A, FOXA2, EZH2phosphoT487, SOX2, XBP1, FOXA1, CDK9, HOXC5, RELA, NOTCH1, JUNB, RUNX2, MYC, GATA4, RUNX3, PBX4, HIF1A, DAXX, PROX1, GATA3, STAT3, FOS, ZNF143, MED1, ARNTL, NR3C1, CEBPB, KLF4, ZEB1, TEAD1, ESRRA, KLF6, SNAI2, HNF1B, GRHL2, JUN, TCF12, ELF3, SPI1, NIPBL, IRF1, GATA6, REST, GATA2, IRF4, BRD4, FOXP1, TEAD4, RBPJ, FOSL2
- Target gene symbol (double-evidenced CRMs): ADAMTS1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 6
- Related genes and loops
- Related gene:
ENSG00000154734,
- Related loop:
chr21:26848701-26852142~~chr21:27474660-27477802,
chr21:26850000-26875000~~chr21:27475000-27500000,
chr21:26880725-26882738~~chr21:27476214-27477477,
chr21:26963690-26966148~~chr21:27475507-27477823,
chr21:26964017-26968392~~chr21:27474660-27477802,
chr21:26966496-26968374~~chr21:27475507-27477823,
chr21:27026114-27027283~~chr21:27476146-27477746,
chr21:27100000-27125000~~chr21:27475000-27500000,
chr21:27300000-27325000~~chr21:27475000-27500000,
chr21:27475000-27500000~~chr21:28325000-28350000,
chr21:27475000-27500000~~chr21:28725000-28750000,
chr21:27476178-27477767~~chr21:27563649-27565742,