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Basic information

CohesinDB ID: CDBP00415903

Locus: chr21-28227896-28231619

Data sourse: ENCSR000EFJ, ENCSR230ZWH, GSE98367, GSE165895, ENCSR000HPG, ENCSR000BLY, GSE206145, GSE206145-NatGen2015, GSE120943, ENCSR000EDE, ENCSR000ECS, ENCSR917QNE

Cell type: RPE, Fibroblast, Monocytes, HeLa-S3, IMR-90, SK-N-SH, Liver, Macrophage, HFFc6

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 7% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.900

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 35% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 60%, "7_Enh": 22%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, PGR, SMARCA2, E2F7, SOX2, NME2, FOXA1, HNRNPK, ATF3, NFIC, CHD7, CDX2, TEAD1, TRIM28, KLF6, ETV1, NFE2L2, ESR1, HNF1B, JUN, CTCF, TCF12, EP300, BAF155, GATA6, RFX5, TEAD4, PDX1, TFAP2C, POU5F1, CTBP1, DUX4, STAT1, ZNF300, ERG, HOXC5, MYC, SMARCA4, RFX1, RAD21, LHX2, TOP1, GRHL3, RXRA, BATF3, GABPA, STAT3, RCOR1, NFE2, VDR, ZNF750, CEBPB, NR3C1, ESRRA, KMT2A, CREB1, EBF3, ZHX2, SPI1, EHF, IRF1, GATA2, FLI1, MRTFB, NFYB, RUNX1, MAFG, SMC1A, CEBPA, LDB1, SMAD3, PCBP2, SMARCC1, MEF2A, RUNX2, GATA4, SP3, PBX4, ARNT, DAXX, BACH1, NRF1, ATF2, PBX3, MAFB, FOXM1, FOS, CDK8, MED1, CEBPD, PIAS1, SMAD1, C11orf30, TBX5, NUP98-HOXA9, MAFK, BCL11A, SP1, HNF4A, REST, ARID1A, ATF7, ZHX1, NCOR2, PPARG, FOXA2, CHD2, MAFF, MEF2C, ZBTB33, HOXB13, RELA, JUNB, BRG1, ISL1, GATA3, TAL1, MAX, GATA1, HAND2, TLE3, KLF4, TCF7L2, ZNF334, NFKB1, PHOX2B, AR, RNF2, BRD4, JUND, TBX2, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): ADAMTS1,LINC00113

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 20

Related genes and loops

Related gene: ENSG00000154734, ENSG00000225298,

eachgene

Deatailed information for cohesin site CDBP00415903