- Basic information
- CohesinDB ID: CDBP00415621
- Locus: chr21-27046439-27048534
-
Data sourse: ENCSR000EFJ, GSE98367, GSE138405, GSE126634, ENCSR000BLY, GSE206145, GSE152721, GSE206145-NatGen2015, GSE120943, ENCSR000EDE, GSE130135, GSE116344, GSE126990, GSE108869, ENCSR000ECS
-
Cell type: RPE, Hela-Kyoto, Fibroblast, Monocytes, HEK293T, RH4, HeLa-S3, IMR-90, SK-N-SH, HAP1, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 9% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.867
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
-
CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
38% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
-
Chromatin annotation:
"15_Quies": 69%,
"7_Enh": 20%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, SMARCA2, SOX2, NME2, FOXA1, NFIC, CHD7, PAX5, ZSCAN4, TP63, TRIM28, ETV1, NFE2L2, ESR1, OCA2, CTCF, TCF12, JUN, BAF155, EP300, ZNF302, PAX8, ZNF528, TEAD4, PDX1, TFAP2C, GLIS1, NANOG, POU5F1, BRD3, TOP2A, ZNF263, MYCN, DUX4, ZNF205, SRF, BAHD1, TBP, ERG, MYC, ONECUT1, SMARCA4, EOMES, RAD21, GRHL3, NKX2-1, GABPA, STAT3, UBN1, NKX3-1, RCOR1, ZNF750, CEBPB, NR3C1, ESRRA, GATA2, SIX2, FLI1, RELB, RUNX1, NKX2-2, EZH2phosphoT487, AFF4, SMARCC1, TWIST1, ZNF384, RUNX2, GATA4, ARNT, PBX4, NRF1, DAXX, ATF2, PBX3, FOXM1, FOS, CDK8, MED1, PIAS1, USF1, MAFK, ZHX1, ASH2L, HOXA9, FOXP1, PRDM6, SMC3, ELL2, PPARG, FOXA2, MEIS1, MAFF, FOXF1, MEF2C, HOXB13, KDM1A, RELA, NEUROD1, JUNB, BRG1, OTX2, GATA3, MAX, TLE3, NR2F2, TCF7L2, KDM5B, PKNOX1, ZNF334, NFKB1, PHOX2B, BRD2, T, PAX3-FOXO1, AR, BRD4, JUND, FOSL2
- Target gene symbol (double-evidenced CRMs): LINC00113,ADAMTS1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 23
- Related genes and loops
- Related gene:
ENSG00000154734,
ENSG00000225298,
- Related loop:
chr21:26850000-26875000~~chr21:27025000-27050000,
chr21:27025000-27050000~~chr21:27200000-27225000,
chr21:27025000-27050000~~chr21:27550000-27575000,
chr21:27025000-27050000~~chr21:27675000-27700000,
chr21:27025000-27050000~~chr21:27700000-27725000,
chr21:27050000-27075000~~chr21:27200000-27225000,
chr21:27050000-27075000~~chr21:27300000-27325000,
chr21:27050000-27075000~~chr21:27550000-27575000,
chr21:27050000-27075000~~chr21:27675000-27700000,
chr21:27050000-27075000~~chr21:28325000-28350000,