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Basic information

CohesinDB ID: CDBP00416123

Locus: chr21-29102975-29105726

Data sourse: ENCSR230ZWH, ENCSR000BLY, GSE131606, GSE108869, GSE165895, ENCSR000EFJ, GSE93080, ENCSR000EAC, ENCSR000DZP, GSE67783, ENCSR000BKV, GSE138405, GSE101921, GSE206145-NatGen2015, GSE138105, GSE116344, GSE206145, ENCSR000BMY, ENCSR000EHX, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE50893, ENCSR000ECS, GSE73207

Cell type: RH4, GM2610, SLK, GM19240, Liver, HuCC-T1, RPE, GM2630, HMEC, Fibroblast, HeLa-S3, GM2255, IMR-90, K-562, GM18486, HFFc6, DKO, TF-1, GM12878, GM12891, GM2588, SK-N-SH, GM19239, GM19193, Hela-Kyoto, GM19238, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 13% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.700

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 72% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 45%, "5_TxWk": 27%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: NFIA, NANOG, CHD8, CEBPA, FOXA2, ZFX, FOXA1, ZBTB33, DDX5, HOXB13, SMARCC1, ERG, YY1, JUNB, ONECUT1, HOMEZ, RAD21, RXRA, SMAD4, NKX3-1, FOS, TLE3, NR3C1, CEBPB, KLF5, TRIM28, CREB1, PIAS1, CTCF, BCL11A, SP1, SPI1, HNF4A, BAF155, AR, GATA2, EED, JUND, BRD4, FOSL2

Target gene symbol (double-evidenced CRMs): BACH1,MAP3K7CL,GRIK1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 36

Number of somatic mutations (non-coding): 6

Related genes and loops

Related gene: ENSG00000156265, ENSG00000156273, ENSG00000171189,

eachgene

Deatailed information for cohesin site CDBP00416123