- Basic information
- CohesinDB ID: CDBP00416127
- Locus: chr21-29117017-29117809
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Data sourse: GSE62063, GSE50893
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Cell type: GM2630, Ramos, GM2588
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.967
- Subunit: NIPBL,SA1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
72% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 66%,
"5_TxWk": 18%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, SMARCA2, ZNF660, SOX2, XBP1, PATZ1, FOXA1, PBX2, ZFHX2, SFMBT1, TFAP4, ATF3, NFIC, BMI1, ZFP64, CHD7, PRDM1, IKZF3, RUNX3, ZBTB44, KLF14, ZNF189, BACH2, ZNF629, KLF5, TEAD1, TRIM28, BCLAF1, ELF1, NFE2L2, KLF10, ZNF217, ESR1, USF2, ZNF561, ZNF577, JUN, TCF12, EP300, CTCF, DPF2, E2F6, IRF4, RFX5, DEK, E2F1, ZNF677, TEAD4, GTF2F1, PDX1, TFAP2C, EED, RBPJ, GLIS1, NANOG, CHD8, POU2F2, BRD3, TOP2A, CTBP1, ZNF317, ZBTB17, ZSCAN21, ZBTB48, MTA2, SRF, ERG2, SP4, TBP, HOXC5, ZBTB21, ERG, ZNF329, ZBTB8A, MYC, SMARCA4, RAD21, GRHL3, RXRA, NKX2-1, BATF3, STAT3, IKZF1, RCOR1, ZNF639, NR2F6, VDR, ZNF750, NR3C1, CEBPB, CREB1, GRHL2, FEZF1, MRTFA, SPI1, HDAC2, GATA2, GATAD2B, FLI1, NR2C2, SMARCA5, ZNF766, MRTFB, ZNF554, RUNX1, MAFG, BCL6, SMC1A, ZNF335, ZFX, AFF4, SMAD3, ZNF770, ERG3, CBX8, SMARCC1, PRDM10, MEF2A, CREBBP, ZNF35, RUNX2, CDK6, OSR2, ZNF184, PBX4, DAXX, ZEB2, ZNF518A, FOXM1, MAFB, NR2C1, FOS, CDK8, ETV6, PBX3, MED1, ZNF558, ZNF680, C11orf30, L3MBTL2, SETDB1, MAFK, NIPBL, SP1, BCL11A, HNF4A, ARID2, REST, ZHX1, ASH2L, HOXA9, PHIP, BCOR, FOXP1, PRDM6, SMC3, ELL2, NCOR2, ZNF34, ZNF394, ZNF283, MEF2B, PPARG, FOXA2, ZNF316, EBF1, CHD2, SS18, CREM, ZNF692, ZSCAN16, MAFF, WT1, GTF2B, ZBED1, ZNF574, ZNF662, TCF7, CDK9, HOXB13, YY1, RELA, JUNB, ZIC2, ZFP36, SKIL, GATA3, BATF, TAL1, MAX, NRIP1, ZNF143, CBX2, ZFP69B, KLF4, SP7, NR2F2, TCF7L2, NR2F1, NEUROG2, TP53, PKNOX1, NFKB1, PHOX2B, T, BRD2, AR, TAF1, ZNF324, ZBTB42, ZNF366, NCOR1, RNF2, BRD4, JUND, IKZF2, ZNF24, AHR, FOSL2
- Target gene symbol (double-evidenced CRMs): GRIK1,BACH1,MAP3K7CL
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 14
- Number of somatic mutations (non-coding): 2
- Related genes and loops