- Basic information
- CohesinDB ID: CDBP00416135
- Locus: chr21-29144173-29147556
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Data sourse: ENCSR000BLY, GSE108869, GSE165895, ENCSR000EFJ, GSE115250, GSE138405, GSE101921, GSE206145-NatGen2015, GSE120943, GSE116344, GSE118494, GSE98367, GSE206145, GSE85526, ENCSR000EHX, ENCSR000HPG, GSE111913, ENCSR000EDE, GSE68388, GSE83726, GSE126990, ENCSR000ECS
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Cell type: RPE, Macrophage, HMEC, Hela-Kyoto, Fibroblast, Monocytes, HEKn, RH4, HCAEC, HeLa-S3, IMR-90, SK-N-SH, RT-112, TC-32, HFFc6, HuCC-T1, B-cell
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 11% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.811
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES,Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: False
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
72% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 35%,
"7_Enh": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, SMARCA2, ZNF697, ZNF660, SOX2, MEIS2, XBP1, HNF1A, FOXA1, PBX2, TFAP4, ATF3, NFIC, CHD7, ZNF189, TP63, MYOG, ZNF629, MAF, TEAD1, ELF1, ETV1, SNAI2, NFE2L2, ESR1, OCA2, HNF1B, TP73, CTCF, JUN, TCF12, EP300, BAF155, ARID5B, LMO1, ZNF157, SOX4, TRIM24, DEK, E2F1, ZNF350, SMC1, TEAD4, PDX1, TFAP2C, RBPJ, NANOG, MYCN, BRD3, CDK7, POU5F1, ERF, ZBTB17, DUX4, MTA2, STAT1, ZBTB48, ZNF563, SRF, DDX5, BAHD1, HNF4G, HOXC5, ERG, PBX1, ETS1, MYC, SMARCA4, ARID1B, RAD21, FOXP2, GRHL3, RXRA, NKX2-1, GABPA, STAT3, UBN1, NKX3-1, RCOR1, ZNF667, DACH1, VDR, ARNTL, NR3C1, CEBPB, KMT2A, GRHL2, ZHX2, SPI1, EHF, IRF1, GATA2, FLI1, ZNF490, MRTFB, MYF5, RUNX1, SMC1A, CEBPA, EZH2phosphoT487, NKX2-2, CRY1, SIN3A, ZFX, ZNF335, SMAD3, ZNF770, TWIST1, PRDM10, SMARCC1, MEF2A, RARA, ZNF35, RUNX2, CDK6, GATA4, OSR2, ZNF184, PBX4, DAXX, SOX11, ZEB2, HMBOX1, PBX3, CBFA2T3, FOXM1, FOS, CDK8, CHD1, SUPT5H, MED1, ZEB1, CEBPD, MYB, SCRT2, PIAS1, EVI1, MAFK, BCL11A, NIPBL, SP1, REST, ARID1A, RBM25, ZHX1, ASH2L, TCF3, FOXP1, SMC3, ELL2, MLLT1, STAG2, MEF2B, PPARG, FOXA2, MEIS1, SS18, NFATC1, ZNF600, ZNF692, GTF2B, ZSCAN16, FOXF1, MEF2C, ZBTB33, CDK9, HOXB13, KDM1A, YY1, RELA, JUNB, NEUROD1, BRG1, BRCA1, TCF4, HIF1A, OTX2, GATA3, TAL1, MAX, ZNF449, ZNF143, TLE3, CEBPG, KLF4, SP7, BCL11B, NR2F2, NEUROG2, TP53, MED, ZNF334, NFKB1, MYOD1, BRD2, ELF3, BHLHE40, AR, PAX3-FOXO1, TAF1, ZBTB16, YAP1, HEXIM1, RNF2, NOTCH3, BRD4, JUND, ZNF24, FOSL2
- Target gene symbol (double-evidenced CRMs): MAP3K7CL
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 140
- Number of somatic mutations (non-coding): 10
- Related genes and loops