- Basic information
- CohesinDB ID: CDBP00416143
- Locus: chr21-29161992-29169830
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, T-47D, A-549, HUVEC, HCAEC, Ramos, GM19238, HeLa, CNCC-WT33iPSC, TC-71, Neutrophil, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 82% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.156
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
72% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 37%,
"5_TxWk": 31%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: LDB1, ZNF384, SPI1, MITF
- Target gene symbol (double-evidenced CRMs): GRIK1,BACH1,MAP3K7CL
- Function elements
- Human SNPs: Coronary_artery_disease
- Number of somatic mutations (coding): 290
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000156265,
ENSG00000156273,
ENSG00000171189,
- Related loop:
chr21:29089111-29092269~~chr21:29162377-29165492,
chr21:29091975-29093600~~chr21:29162298-29165502,
chr21:29150000-29175000~~chr21:29275000-29300000,
chr21:29150000-29175000~~chr21:29325000-29350000,
chr21:29150000-29175000~~chr21:29350000-29375000,
chr21:29150000-29175000~~chr21:29475000-29500000,
chr21:29150000-29175000~~chr21:29825000-29850000,
chr21:29150000-29175000~~chr21:30175000-30200000,
chr21:29162246-29165257~~chr21:29217358-29218786,
chr21:29162298-29165502~~chr21:29297765-29300738,
chr21:29162305-29165453~~chr21:29297767-29300990,
chr21:29162305-29165453~~chr21:29347649-29349937,
chr21:29162305-29165453~~chr21:29371510-29373232,
chr21:29162307-29165517~~chr21:29297019-29300536,
chr21:29162307-29165517~~chr21:29371097-29373582,
chr21:29162310-29165464~~chr21:29297711-29300996,
chr21:29162310-29165464~~chr21:29371472-29373597,
chr21:29162316-29165407~~chr21:29347639-29349336,
chr21:29162316-29165407~~chr21:29371587-29373476,
chr21:29162347-29165506~~chr21:29347569-29349367,
chr21:29162347-29165506~~chr21:29371508-29373478,
chr21:29162377-29165492~~chr21:29297770-29301094,
chr21:29162377-29165492~~chr21:29371324-29373748,
chr21:29162378-29165498~~chr21:29297718-29300698,
chr21:29162378-29165498~~chr21:29347586-29349777,
chr21:29162378-29165498~~chr21:29371396-29373685,
chr21:29162871-29165217~~chr21:29297676-29300550,
chr21:29162871-29165217~~chr21:29371415-29373460,
chr21:29162973-29165491~~chr21:29371374-29374062,
chr21:29163076-29165466~~chr21:29371531-29373749,
chr21:29163267-29165505~~chr21:29371371-29373442,
chr21:29163284-29165488~~chr21:29347632-29349367,
chr21:29163284-29165488~~chr21:29371469-29373463,
chr21:29163305-29165274~~chr21:29297780-29300635,
chr21:29163327-29165509~~chr21:29371286-29373596,
chr21:29163333-29165304~~chr21:29297741-29300792,
chr21:29163333-29165304~~chr21:29347811-29349358,
chr21:29163334-29165506~~chr21:29371501-29373446,
chr21:29163344-29165555~~chr21:29371154-29373646,
chr21:29163366-29165439~~chr21:29371508-29373470,
chr21:29163425-29165457~~chr21:29371556-29373423,
chr21:29163439-29165245~~chr21:29347811-29349339,
chr21:29163441-29165302~~chr21:29371582-29373416,
chr21:29163452-29165270~~chr21:29371509-29373661,
chr21:29163509-29165242~~chr21:29347678-29349344,
chr21:29163629-29165264~~chr21:29297785-29301017,
chr21:29163629-29165264~~chr21:29347677-29349365,
chr21:29163690-29165671~~chr21:29370899-29373222,
chr21:29163705-29165544~~chr21:29371661-29373191,
chr21:29163714-29165477~~chr21:29347632-29349309,
chr21:29163714-29165477~~chr21:29371612-29373705,
chr21:29163723-29165657~~chr21:29371051-29373223,
chr21:29163725-29165459~~chr21:29347656-29349372,
chr21:29163734-29165276~~chr21:29347684-29349339,
chr21:29163746-29165675~~chr21:29347638-29349313,
chr21:29163746-29165675~~chr21:29371508-29373687,
chr21:29163756-29165286~~chr21:29347699-29349347,
chr21:29163791-29165490~~chr21:29371644-29373204,
chr21:29163801-29165267~~chr21:29347792-29349359,
chr21:29163801-29165269~~chr21:29347138-29349317,
chr21:29163806-29165395~~chr21:29499245-29500556,
chr21:29163806-29165395~~chr21:29848934-29850864,