Deatailed information for gene ENSG00000156261
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00009957
- Gene Symbol: CCT8
- Ensembl ID: ENSG00000156261
-
Gene locus: chr21:29056321-29073797
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-28951723-28951953,
chr21-28959314-28959751,
chr21-28961868-28962960,
chr21-28968738-28969112,
chr21-29051564-29051818,
chr21-29053116-29053515,
chr21-29054263-29054943,
chr21-29057293-29057849,
chr21-29058619-29059007,
chr21-29063826-29064273,
chr21-29064621-29065502,
chr21-29066238-29066599,
chr21-29071350-29071693,
chr21-29072018-29074622,
chr21-29074884-29075433,
chr21-29075829-29075966,
chr21-29076222-29078000,
chr21-29174072-29177013,
chr21-29177913-29178352,
chr21-29180907-29186165,
chr21-29187616-29191797,
chr21-29192039-29192372,
chr21-29192661-29199386,
chr21-29202234-29202641,
chr21-29205492-29205830,
chr21-29207162-29210453,
chr21-29211818-29212688,
chr21-29213561-29214401,
chr21-29215632-29220031,
chr21-29220845-29223441,
chr21-29223760-29224997,
chr21-29277558-29277792,
chr21-29281119-29281788,
chr21-29287057-29289061,
chr21-29289505-29290651,
chr21-29293004-29294050,
chr21-29295121-29295701,
chr21-29296491-29303668,
chr21-29304154-29305335,
chr21-29305747-29309169,
chr21-29313792-29314472,
chr21-29315462-29315610,
chr21-29315990-29317552,
chr21-29318199-29318712,
chr21-29319627-29319847,
chr21-29320109-29320295,
chr21-29320703-29320863,
chr21-29321259-29321494,
chr21-29321914-29322368,
chr21-29322647-29323646,
chr21-29323911-29324647,
chr21-29324965-29325251,
chr21-29327253-29327738,
chr21-29329533-29331103,
chr21-29331917-29333531,
chr21-29334032-29336486,
chr21-29336792-29337311,
chr21-29337668-29337930,
chr21-29339151-29339890,
chr21-29340708-29341150,
chr21-29341735-29344513,
chr21-29345772-29351015,
chr21-29351420-29352466,
chr21-29352759-29353073,
chr21-29354819-29355356,
chr21-29356096-29358712,
chr21-29359610-29363005,
chr21-29365312-29366158,
chr21-29367279-29367632,
chr21-29368384-29387783,
chr21-29389743-29390744,
chr21-29392252-29392879,
chr21-29394941-29397193,
chr21-29457390-29457655,
chr21-29459661-29460114,
chr21-29463783-29464015,
chr21-29465600-29465837,
chr21-29469142-29469499,
chr21-29470559-29470708,
chr21-29472555-29472793,
chr21-29473888-29474622,
chr21-29475468-29478798,
chr21-29481578-29482796,
chr21-29485004-29485661,
chr21-29495641-29495966,
chr21-29496266-29496695,
chr21-29498142-29498791,
chr21-29499024-29500817,
chr21-29504406-29504779,
chr21-29504996-29505264,
chr21-29505770-29506068,
chr21-29639308-29651372,
chr21-29652623-29653297,
chr21-29654700-29655747,
chr21-29656026-29658007,
chr21-29658295-29660604,
chr21-29661789-29662394,
chr21-29667605-29667982,
chr21-29669366-29669693,
chr21-29669973-29670688,
chr21-29671768-29672148,
chr21-29673085-29673417,
chr21-29827930-29828093,
chr21-29828792-29830452,
chr21-29843651-29844212,
chr21-29847336-29847578,
chr21-29847880-29847942,
chr21-29848227-29851703,
chr21-29854684-29855206,
chr21-29867790-29868026,
chr21-29870913-29871168,
chr21-30032176-30032527,
chr21-30033467-30033926,
chr21-30035043-30035297,
chr21-30044217-30045461,
chr21-30046773-30047436,
chr21-30191933-30192080,
chr21-30193663-30195325,
chr21-30452170-30452755,
chr21-30458021-30458348,
chr21-30460297-30460641,
chr21-30463194-30464181,
-
Co-expression with cohesin genes Rho = 0.6231
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.255
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.881
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,MCF-10A,TAMR-MCF7,MB157,Keratinocytes192627,Spleen,H1-Mesenchymal,H1-Mesendoderm,Olfactory,MCF-7,HEK293T,SARS-Cov2-olfactory,GM12878,K-562,A-549,CyT49-pancreatic,HFFc6,HeLa-S3,H1-Trophectoderm,H9-hESC,iPSC,Liver,HCT-116,Hep-G2,HT-1197,H1-hESC,HCC1599,Motor-Neuron,NaiveB,U-937,BMEC,HUES64,H1-NPC,CyT49-hESC,HUVEC,HL-60,RT-112,CyT49-endoderm,KBM-7,CyT49-Gut,CC-2551,HAP1,HFF-hTERT,MCF7-FASR
- Related loop:
chr21:25750000-25775000~~chr21:29050000-29075000,
chr21:26175000-26200000~~chr21:29075000-29100000,
chr21:28950000-28975000~~chr21:29050000-29075000,
chr21:29050000-29075000~~chr21:29300000-29325000,
chr21:29050000-29075000~~chr21:31675000-31700000,
chr21:29050000-29075000~~chr21:32300000-32325000,
chr21:29050000-29075000~~chr21:32325000-32350000,
chr21:29050000-29075000~~chr21:32350000-32375000,
chr21:29050000-29075000~~chr21:32625000-32650000,
chr21:29050000-29075000~~chr21:32725000-32750000,
chr21:29050000-29075000~~chr21:32750000-32775000,
chr21:29050000-29075000~~chr21:33500000-33525000,
chr21:29050000-29075000~~chr21:33550000-33575000,
chr21:29050000-29075000~~chr21:39175000-39200000,
chr21:29064179-29066014~~chr21:29375886-29377472,
chr21:29075000-29100000~~chr21:29175000-29200000,
chr21:29075000-29100000~~chr21:29200000-29225000,
chr21:29075000-29100000~~chr21:29275000-29300000,
chr21:29075000-29100000~~chr21:29325000-29350000,
chr21:29075000-29100000~~chr21:29350000-29375000,
chr21:29075000-29100000~~chr21:29375000-29400000,
chr21:29075000-29100000~~chr21:29450000-29475000,
chr21:29075000-29100000~~chr21:29475000-29500000,
chr21:29075000-29100000~~chr21:29650000-29675000,
chr21:29075000-29100000~~chr21:29825000-29850000,
chr21:29075000-29100000~~chr21:29850000-29875000,
chr21:29075000-29100000~~chr21:30025000-30050000,
chr21:29075000-29100000~~chr21:30175000-30200000,
chr21:29075000-29100000~~chr21:30450000-30475000,
chr21:29075000-29100000~~chr21:31075000-31100000,
chr21:29075000-29100000~~chr21:31175000-31200000,
chr21:29075000-29100000~~chr21:31600000-31625000,
chr21:29076937-29078408~~chr21:29504618-29505774,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIQYQWPF5, GSE95015, GSE43070, 4DNFITUOMFUQ, ENCSR794RDS, 4DNFIBN9K4V9, ENCSR852KQC, 4DNFIDSWKFF5, 4DNFIZ4F74QR, 4DNFI7H4II2V, 4DNFIEYQ5ZIR, 4DNFIREVU1Z5, 4DNFIA6NSSBJ, 4DNFI9VXTBE2, 4DNFIKYXMF1E, 4DNFIRKGMZRQ, GSE97394, 4DNFICEGAHRC, 4DNFIE8T8JZ8, 4DNFI1E6NJQJ, 4DNFI9YAVTI1, 4DNFIJ5DQZVK, 4DNFI6XD6JAQ, 4DNFISPUVQHA, 4DNFIK61ILGM, GSE108869, GSE116872, 4DNFIAWVDQ8C, ENCSR305RTT, 4DNFI7XAZNNQ, GSE105028, 4DNFIBKZK63V, 4DNFIQWD8ZYD, GSE87112, 4DNFI3CFMRID, ENCSR662QKG, GSE94872, GSE118716, ENCSR499RVD, 4DNFIB7QTIMH, 4DNFIOX3BGNE, GSE155380, 4DNFIJWBWE41, 4DNFICSTCJQZ, 4DNFIIMZB6Y9, GSE52457, 4DNFIBT4EAKN, Direct, 4DNFIAS8LV1C, 4DNFIX7H3CE2, 4DNFIYIAUEPW, ENCSR244BBG, 4DNFI9815EEJ, 4DNFI9ZWZ5BS, 4DNFIVJ3IIQL, 4DNFI2J1ODWB, 4DNFIQ2687RT, 4DNFIFLJLIS5, 4DNFIDBIEXI7, 4DNFIDZT7PR8, 4DNFIS5F6EBL, 4DNFIZGCA8AH, 4DNFIH7TH4MF, 4DNFIT96Z365, 4DNFIWZEN3FF, ENCSR194SRI, 4DNFIBRSIPE4, 4DNFI6CWNUFL, 4DNFIR8OU6QJ, 4DNFIE8E4ANZ, GSE120294, GSE84022, 4DNFIPV5KFMK, 4DNFIW8TIFI5, ENCSR410MDC, 4DNFIMEG1QIC, 4DNFIBM714BP, 4DNFIF2D3TL9, 4DNFIYD8LO9Z, ENCSR444BAR, 4DNFIL9M97T2, 4DNFIJBJ6QVH, ENCSR550JLK, 4DNFI3A3VYWU, 4DNFIM2BMJ33, GSE165038, 4DNFIALNLR78, 4DNFIBY3UHJB, 4DNFIYDBBSE3, ENCSR386KHY, 4DNFIEJEFCAM, ENCSR393LOP, GSE44267, 4DNFIPAF4PYT, GSE48592, 4DNFIE5TEYK7, 4DNFIJ8JKKWJ, 4DNFIFI6NIKJ, 4DNFIDKJFK2S, ENCSR094EIC, GSE58752, ENCSR507AHE, GSE116869, 4DNFI8649RQJ, 4DNFIRZA6EV6, 4DNFIMROE6N4, GSE108787, 4DNFI5SUHCGZ, ENCSR545YBD, 4DNFIILDWK8M, ENCSR866FWQ, 4DNFI6EIFUZI, 4DNFII6AN691, GSE131580, ENCSR981FNA, 4DNFIV239W4L, 4DNFI6JJQKFJ, 4DNFI1UEG1HD, GSE101921, ENCSR228TUX, 4DNFI8JFOAJT, 4DNFIC3HAU11, 4DNFI5LCW273, 4DNFINEQY95T, 4DNFIHN2QSMX, 4DNFII84FBKM, 4DNFIVSCH2CH
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: SLK,P3HR-1,K-562,HAP1,U2OS,HeLa-S3
- Cohesin-DEGs, number of studies: 7
- Cohesin-DEGs, study: GSE140651,GSE126635,GSE131448,GSE138937,GSE89799,GSE130558
- Cohesin-DEGs, subunit: SA2,WAPL,CTCF,SMC1,Rad21