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Basic information

CohesinDB ID: CDBP00416113

Locus: chr21-29076222-29078000

Data sourse: GSE118494, GSE131606, ENCSR230ZWH, GSE67783, GSE86191, GSE98367, GSE116868, GSE111913, GSE206145-NatGen2015, ENCSR153HNT, GSE83726, GSE116344, ENCSR495WGO, GSE50893, GSE165895

Cell type: GM2630, Fibroblast, HCT-116, RH4, GM18505, MB157, A-549, GM19238, RT-112, GM2255, HSPC, IMR-90, K-562, Liver, HFFc6, Macrophage, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 6% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.811

Subunit: SA1,Rad21,SMC1,SA2,Mau2

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 72% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 32%, "1_TssA": 30%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXA1, LEO1, HDGF, ATF3, CBFB, PAX5, MAF, ELF1, TRIM28, KLF6, CTCF, TCF12, JUN, BAF155, KLF1, DPF2, E2F6, IRF4, RAD51, E2F1, POU2F2, TOP2A, ZBTB48, NBN, TBP, ERG, OGG1, MYC, GRHL3, PROX1, NKX2-1, STAT3, IKZF1, ZNF750, NR3C1, KMT2A, ZHX2, SPI1, IRF1, GATA2, INTS13, HCFC1, RELB, ZIM3, NFYB, RUNX1, NKX2-2, SIN3A, TRIM22, SMARCC1, NOTCH1, RUNX2, GATA4, NRF1, FOS, MED1, SMAD1, SP1, REST, ATF7, ASH2L, AATF, MLLT1, NFATC3, E2F8, GTF2B, ZBTB33, CDK9, BCL3, YY1, RELA, TARDBP, SKIL, TAL1, MAX, GATA1, KLF4, NR2F2, KDM5B, ZNF687, TP53, MED, MYOD1, BRD2, TBX21, TAF1, ZBTB40, RB1, BRD4

Target gene symbol (double-evidenced CRMs): MAP3K7CL,BACH1,GRIK1,CCT8,KRTAP19-1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 3

Number of somatic mutations (non-coding): 13

Related genes and loops

Related gene: ENSG00000156261, ENSG00000156265, ENSG00000156273, ENSG00000171189, ENSG00000184351,

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Deatailed information for cohesin site CDBP00416113