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Basic information

CohesinDB ID: CDBP00416111

Locus: chr21-29074884-29075433

Data sourse: GSE62063, ENCSR153HNT

Cell type: K-562, Ramos

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: NIPBL,SA1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 72% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 70%, "7_Enh": 16%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, NME2, FOXA1, RXRB, MLL4, KDM3A, ZBTB7B, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, ZNF320, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, ARID5B, SOX5, PAX8, E2F4, DEK, ZNF528, RFX3, KMT2B, GATAD2A, NANOG, POU5F1, ZNF263, TOP2A, BRD3, CTBP1, ZMYND11, DUX4, STAT1, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, FOXK2, RCOR1, NR2F6, CD74, CEBPB, HNRNPL, CREB1, DDX21, BMPR1A, GABPB1, ELF4, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, NR2C2, RELB, EP400, RUNX1, CEBPA, HDAC1, NKX2-2, TET2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ZXDC, SOX11, TFDP1, ELK1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, GSPT2, ARID2, IKZF5, OVOL3, RBM25, ZSCAN31, AFF1, MBD2, ELL2, ETV4, NFATC3, ZSCAN18, CBFA2T2, MEF2B, CBX3, CREM, CHD2, PAF1, NFATC1, WT1, MEF2C, MPHOSPH8, CREB3L1, NEUROD1, JUNB, TCF4, ZFP36, BATF, PLAG1, ZFP69B, BCL11B, KLF4, ZNF281, IRF5, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, HNF1A, KDM4B, ZNF101, PBX2, ZNF596, ATF3, THRB, ZFP64, RUNX3, WDHD1, CBFB, ZNF273, ZSCAN4, TP63, MITF, ZNF467, MAF, JMJD1C, INTS11, ELF1, RBM39, SNAI2, KLF10, SMAD5, CTCF, JUN, TAF3, MNT, ZBTB20, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF280A, PDX1, RBPJ, TFAP2C, MLX, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, ZNF317, NONO, SRF, NBN, ONECUT1, KDM4A, ZNF2, TSHZ1, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, FOXK1, CCAR2, TBL1XR1, KLF8, ARHGAP35, GRHL2, EBF3, ZKSCAN5, KDM5A, ZBTB14, SSRP1, ZNF146, SMARCA5, NFIL3, CC2D1A, THAP11, CTNNB1, ZNF585A, LDB1, AFF4, SOX13, POU4F2, ZNF770, ZMIZ1, ZNF18, CEBPZ, SP3, ARNT, BACH1, DAXX, ZNF48, HMBOX1, ZEB2, NFYA, ETV6, NCAPH2, ZNF10, PBX3, HMGXB4, TEAD3, DIDO1, ZXDB, ZNF680, U2AF1, TAF7, KLF9, ZBTB18, USF1, BCL11A, SP1, TFAP2A, NKX2-5, ATF7, ASH2L, ZNF548, CTBP2, GLIS2, ZNF623, SMC3, MLLT1, STAG1, ZNF394, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, ZKSCAN1, KDM1A, KLF7, ISL1, ZIC2, PCGF1, GATA3, TAL1, ZNF143, AGO2, CBX2, TP53, ZNF334, ZSCAN22, NFKB1, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, RNF2, IKZF2, BRD4, JUND, SPIN1, CUX1, ZSCAN23, PGR, SOX2, PATZ1, LEO1, UBTF, TFAP4, SIN3B, BMI1, SETX, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, SAP30, ESR1, ZNF524, KLF1, SOX4, E2F6, TRIM24, RFX5, PRKDC, GTF2F1, GLIS1, POU2F2, ZNF778, KDM4C, ZBTB1, ASH1L, ZSCAN5A, ELK4, ERG2, SP4, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ZNF671, KLF12, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, ZNF343, INO80, DNMT3B, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, PCBP1, HDAC2, RBP2, INTS13, GATAD2B, TAF9B, NCOA2, ZNF76, NFYB, ZNF554, ETV5, BCL6, SIN3A, ZBTB12, ZFP37, ERG3, MEF2A, CREBBP, ZNF384, ZNF35, ZNF133, RARA, TAF15, NFYC, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, SUPT16H, NCOA1, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, HOXA9, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, JDP2, ZNF574, YY2, RELA, TARDBP, ZNF282, SKIL, MAX, GFI1B, TCF7L2, NR2F1, KDM5B, PKNOX1, MYOD1, T, AR, PAX3-FOXO1, KMT2D, ZBTB16, YAP1, ZNF324, ZZZ3, DMAP1, AHR, FOSL2, ZNF391, HMG20A, ZSCAN5C, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, NFIC, ZNF362, PRDM1, KLF14, GLYR1, MECOM, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, MLL, HNF1B, USF2, TCF12, BAF155, EP300, GATA6, SOX6, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, CDK7, ID3, RUNX1T1, MLLT3, GATAD1, GMEB2, ARID3A, USP7, MIER1, ZNF341, RAD21, GRHL3, APC, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, ZNF750, FEZF1, HBP1, TFE3, EHF, IRF1, ZNF664, SREBF1, ZGPAT, ZNF766, MRTFB, MYF5, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, ZSCAN30, PBX4, NRF1, NR2C1, SUPT5H, CHD1, FOS, TGIF2, MED1, CEBPD, MYB, SCRT2, ZNF558, KDM6B, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, PHF20, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, PAX7, NELFA, SKI, FOXA2, RBBP5, E2F8, MIER2, ZNF600, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, ZNF843, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, ZBTB42, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): BACH1,LTN1,GRIK1,MAP3K7CL,CCT8,KRTAP19-1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000198862, ENSG00000156261, ENSG00000156265, ENSG00000156273, ENSG00000171189, ENSG00000184351,

eachgene

Deatailed information for cohesin site CDBP00416111