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Basic information

CohesinDB ID: CDBP00413614

Locus: chr21-15893413-15897253

Data sourse: ENCSR000BLD, GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BSB, ENCSR501LQA, GSE126634, ENCSR760NPX, ENCSR000BLY, ENCSR404BPV, ENCSR150EFU, GSE105028, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, GSE62063, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, GSE165895, ENCSR000EAC, ENCSR000BKV, GSE115250, GSE138405, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, ENCSR703TNG, GSE116344, GSE138105, GSE145327, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR193NSH, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE206145, ENCSR000ECE, ENCSR247LSH, ENCSR000BMY, ENCSR000EHX, ENCSR620NWG, ENCSR748MVX, ENCSR767DFK, ENCSR807WAC, ENCSR495WGO, ENCSR981FDC, ENCSR984DZW, GSE97394, ENCSR217ELF, ENCSR000BTQ, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE110061, GSE129526, ENCSR000HPG, ENCSR676MJK, ENCSR335RKQ, ENCSR000EDE, GSE68388, GSE83726, GSE126990, GSE50893, ENCSR000ECS

Cell type: MDM, RH4, GM2610, SLK, GM19240, Liver, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, THP-1, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, GM12878, GM12891, GM2588, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, HAP1, GM19099, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 46% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.433

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 58% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 63%, "5_TxWk": 13%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, ZNF426, PGR, ZNF496, XBP1, HNF1A, FOXA1, SUZ12, LEO1, SRSF4, ATF3, PRDM1, ATF4, MORC2, PAX5, ZSCAN4, TEAD1, SNAI2, ESR1, HNF1B, TP73, CTCF, JUN, BAF155, DPF2, E2F6, SMC1, TEAD4, TFAP2C, POU2F2, CHD8, ZSCAN5D, TOP2A, DUX4, ZSCAN5A, SRF, DDX5, ERG, MYC, SMARCA4, RAD21, GRHL3, NKX2-1, GABPA, NKX3-1, TERF2, DACH1, ARNTL, NR3C1, ESRRA, CEBPB, EZH2, GRHL2, EBF3, SPI1, IRF1, GATA2, SIX2, RUNX1, SMC1A, NKX2-2, ZFX, ZNF654, SMARCC1, ZBTB2, ZNF384, ZNF133, RUNX2, GATA4, ARNT, NRF1, ATF2, HMGB2, SUPT5H, MED1, PIAS1, C11orf30, ZNF41, L3MBTL2, ZNF22, RBM22, MAFK, BCL11A, FOXP1, SMC3, NCOR2, STAG1, STAG2, NFATC3, PPARG, FOXA2, PAF1, NFATC1, GTF2B, MAFF, FOXF1, CDK9, HOXB13, ZKSCAN1, MPHOSPH8, KDM1A, YY1, RELA, BCL3, JUNB, BRG1, ZFP36, HIF1A, OTX2, GATA3, TAL1, MAX, GATA1, AGO2, TLE3, KLF4, ZNF334, PHOX2B, T, AR, PAX3-FOXO1, NOTCH3, SCRT1, BRD4, CUX1, MAZ, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): CXADR,HSPA13,BTG3

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 35

Related genes and loops

Related gene: ENSG00000155304, ENSG00000154639, ENSG00000154640,

eachgene

Deatailed information for cohesin site CDBP00413614