- Basic information
- CohesinDB ID: CDBP00413940
- Locus: chr21-17436920-17439074
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Data sourse: ENCSR000BLD, ENCSR167MTG, GSE206145-GSE177045, GSE67783, GSE72082, GSE76893, ENCSR000BLY, ENCSR000BLS, GSE105028, GSE206145, ENCSR000ECE, ENCSR054FKH, GSE62063, ENCSR000EHX, GSE25021, ENCSR000EDW, GSE97394, GSE64758
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Cell type: MCF-7, H1-hESC, RPE, Hep-G2, HEK293T, Ramos, HUES64, SK-N-SH, HSPC, H9-hESC
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 6% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.889
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
47% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 40%,
"7_Enh": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, PGR, HMG20A, ZSCAN5C, ZNF660, SOX2, FOXA1, RBFOX2, RXRB, HNRNPK, TFAP4, THRB, ZFP64, ZBTB44, PRDM1, CHD7, IKZF3, MORC2, ZNF189, ZNF320, HDAC3, CDX2, ZNF467, JMJD1C, ELF1, TRIM28, TEAD1, ETV1, RCOR2, COBLL1, OCA2, TP73, PITX3, ZNF561, CTCF, TCF12, BAF155, EP300, SOX5, GATA6, DMAP1, PRDM4, TEAD4, FOXA3, KMT2B, ZNF175, GATAD2A, PDX1, RBPJ, MLX, TFAP2C, GLIS1, GTF2F1, NANOG, CHD8, BRD3, ZNF263, POU5F1, MYCN, ERF, ZBTB17, ZSCAN21, ZBTB48, GATAD1, SAP130, HIC1, SP4, TBP, HNF4G, ERG, ASCL1, OGG1, ZNF341, NFKB2, MYC, ZNF84, SMARCA4, EOMES, HOMEZ, RAD21, RXRA, GABPA, XRCC5, ZNF614, NKX3-1, PRDM14, RCOR1, MIER3, NR2F6, VDR, CEBPB, CREB1, CCAR2, EZH2, GRHL2, FEZF1, ZNF652, EBF3, ZHX2, SPI1, MIXL1, HBP1, TFE3, PCBP1, HDAC2, GATA2, ZNF644, MXD3, SIX2, GTF3C5, DRAP1, ZGPAT, NFIL3, ETV5, RUNX1, THAP11, BCL6, SMC1A, CEBPA, EZH2phosphoT487, NKX2-2, SOX13, ZNF534, POU4F2, SMAD3, PCBP2, ZNF770, ERG3, SP5, SMARCC1, TWIST1, ZNF18, CREBBP, ZNF35, PRPF4, RARA, ZSCAN30, GATA4, OSR2, ARNT, PBX4, NRF1, ATF2, PRDM9, SMAD4, ZNF48, MAFB, ZNF10, CDK8, HMGXB4, TEAD3, MYB, PIAS1, ZMYM3, SMAD1, NR1H2, RBM22, MAFK, BCL11A, NIPBL, SP1, HNF4A, IKZF5, REST, ARID1A, ASH2L, CTBP2, PHIP, BCOR, FOXP1, PRDM6, SMC3, STAG1, SKI, CBFA2T2, PPARG, FOXA2, ZNF207, EBF1, MEIS1, CREM, CHD2, MIER2, GTF2B, WT1, MAFF, ZNF30, ZNF574, MEF2C, TCF7, CDK9, HOXB13, ZNF580, KDM1A, YY1, RELA, NEUROD1, AHR, BRG1, ZIC2, HIF1A, OTX2, GATA3, TAL1, MAX, GATA1, ZNF143, HAND2, TLE3, CEBPG, KLF4, SP7, GFI1B, TCF7L2, KDM5B, ZBTB6, NFKB1, PHOX2B, BRD2, T, ELF3, KAT8, PHF5A, ARID4B, AR, ZNF366, ZBTB42, ZBTB26, NCOR1, NOTCH3, BRD4, MAZ, ZNF440, ZNF316
- Target gene symbol (double-evidenced CRMs): C21orf91,CXADR
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 17
- Related genes and loops