- Basic information
- CohesinDB ID: CDBP00414000
- Locus: chr21-17584154-17587049
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE38411, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, ENCSR404BPV, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, HSPC, CUTLL1, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, Kelly, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, HAP1, Macrophage, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, HeLa, TC-71, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 66% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.256
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intragenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
60% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 60%,
"5_TxWk": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: PGR, POU2F2, ZNF316, FOXA2, MAFG, ZFX, ZSCAN16, ZBTB48, MAFF, FOXA1, ZNF205, SRF, ERG, RELA, MYC, BRG1, EOMES, GATA4, GR, MCM3, GRHL3, ZFP64, ARNT, RXRA, GATA3, GABPA, GATA1, NR3C1, CEBPB, ESR1, C11orf30, RBM22, MAFK, SP1, SPI1, BCL11A, HNF4A, AR, GATA6, GATA2, BRD4, PHIP, STAG1, AHR
- Target gene symbol (double-evidenced CRMs): CXADR,USP25,C21orf91
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 11
- Number of somatic mutations (non-coding): 0
- Related genes and loops
- Related gene:
ENSG00000155313,
ENSG00000154639,
ENSG00000154642,
- Related loop:
chr21:15875000-15900000~~chr21:17575000-17600000,
chr21:16925000-16950000~~chr21:17575000-17600000,
chr21:16942104-16943784~~chr21:17584882-17586850,
chr21:17375000-17400000~~chr21:17575000-17600000,
chr21:17385933-17388190~~chr21:17585378-17586847,
chr21:17385938-17388768~~chr21:17584830-17586831,
chr21:17385982-17388062~~chr21:17584894-17587061,
chr21:17385997-17387993~~chr21:17584718-17586899,
chr21:17386031-17388049~~chr21:17584682-17586783,
chr21:17386036-17388915~~chr21:17584766-17586992,
chr21:17386038-17389021~~chr21:17584614-17587020,
chr21:17386049-17388075~~chr21:17585127-17586877,
chr21:17386054-17389016~~chr21:17584615-17586797,
chr21:17386056-17387970~~chr21:17585070-17586716,
chr21:17386064-17388904~~chr21:17584829-17586982,
chr21:17386066-17388182~~chr21:17584650-17586844,
chr21:17386069-17388018~~chr21:17584882-17586850,
chr21:17386074-17388534~~chr21:17584717-17586949,
chr21:17386077-17388636~~chr21:17584710-17587013,
chr21:17386079-17388476~~chr21:17584668-17586918,
chr21:17386098-17389064~~chr21:17584658-17586849,
chr21:17386110-17389253~~chr21:17583722-17586723,
chr21:17386111-17388007~~chr21:17585385-17586756,
chr21:17386112-17388058~~chr21:17585381-17586741,
chr21:17386118-17388987~~chr21:17584710-17586759,
chr21:17386120-17388090~~chr21:17584777-17586913,
chr21:17386142-17388075~~chr21:17584963-17586801,
chr21:17386155-17388075~~chr21:17584973-17586950,
chr21:17386210-17388145~~chr21:17585190-17586791,
chr21:17386226-17388006~~chr21:17585307-17586805,
chr21:17386232-17388143~~chr21:17585338-17586757,
chr21:17386274-17388142~~chr21:17585346-17586763,
chr21:17386451-17388123~~chr21:17585377-17586812,
chr21:17386457-17388148~~chr21:17585337-17586760,
chr21:17386482-17388045~~chr21:17585364-17586763,
chr21:17386521-17388914~~chr21:17584891-17586781,
chr21:17386573-17387885~~chr21:17585423-17586769,
chr21:17386602-17387861~~chr21:17585457-17586613,
chr21:17400000-17425000~~chr21:17575000-17600000,
chr21:17575000-17600000~~chr21:17800000-17825000,