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Basic information

CohesinDB ID: CDBP00414010

Locus: chr21-17660473-17661158

Data sourse: GSE138405, GSE126990, GSE108869, GSE67783

Cell type: HeLa-S3, Hela-Kyoto, HSPC

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.967

Subunit: SA1,Rad21,SA2

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 60% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 67%, "14_ReprPCWk": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: PGR, SMARCA2, FOXA2, MYCN, TEAD4, ZFX, SMAD3, FOXA1, MEF2C, ERG3, ERG2, ZFHX2, RELA, ATF3, MYC, RAD21, CHD7, PBX4, SP140, GATA3, STAT3, MAX, FOS, CEBPB, TEAD1, MYB, ESR1, ZNF334, NFKB1, EGR2, PHOX2B, JUN, EP300, SPI1, EHF, REST, TRIM24, ATF7, FLI1, BRD4, SMC3, KMT2B, AHR

Target gene symbol (double-evidenced CRMs): C21orf91,TMPRSS15,CXADR

Function elements

Human SNPs: General_cognitive_ability

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 2

Related genes and loops

Related gene: ENSG00000154639, ENSG00000154642, ENSG00000154646,

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Deatailed information for cohesin site CDBP00414010