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Basic information

CohesinDB ID: CDBP00415304

Locus: chr21-25789892-25791705

Data sourse: ENCSR230ZWH, ENCSR000BSB, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE93080, GSE101921, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, ENCSR247LSH, ENCSR676MJK, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, ENCSR000ECE, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, ENCSR404BPV, GSE105028, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, ENCSR768DOX, ENCSR000BLS, ENCSR000EHW, GSE62063, ENCSR807WAC, ENCSR981FDC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, Liver, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, GM18505, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, GM19238, CNCC-WT33iPSC, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 52% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.356

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 67% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 33%, "14_ReprPCWk": 19%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, ZNF660, ZSCAN5C, SOX2, XBP1, FOXA1, MLL4, ZFHX2, TFAP4, ATF3, ZFP64, ZNF362, CTCFL, ZBTB44, IKZF3, MXD4, MZF1, BACH2, ZNF629, MAF, TEAD1, TRIM28, ZNF121, KLF6, ETV1, NFE2L2, ELF1, RCOR2, ESR1, ZNF217, TP73, PITX3, OCA2, CTCF, JUN, TAF3, BAF155, SOX5, PYGO2, DPF2, E2F6, PRDM4, IRF4, DEK, ZNF528, SMC1, TEAD4, FOXA3, GATAD2A, PDX1, RBPJ, EHMT2, GTF2F1, POU2F2, CHD8, POU5F1, MYCN, RUNX1T1, CDK7, BRD3, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZNF317, STAT1, SRF, GATAD1, SAP130, ERG2, HOXC5, ERG, ZNF341, ETS1, MYC, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, GABPA, ZNF614, XRCC5, IKZF1, RCOR1, NFE2, NR2F6, ZNF639, VDR, NR3C1, CEBPB, KMT2A, CREB1, ZBTB11, EZH2, EBF3, NFE2L1, GABPB1, ZHX2, SPI1, MIXL1, ZSCAN2, IRF1, GATA2, ZNF644, SIX2, FLI1, ZGPAT, MXI1, MRTFB, ETV5, RUNX1, THAP11, ZNF585A, SMC1A, MAFG, CBX1, NKX2-2, CEBPA, SOX13, ZNF534, SIN3A, SMAD3, ZNF654, ERG3, SMARCC1, TWIST1, PRDM10, ZNF549, ZBTB2, ZNF384, ZNF35, CBX4, RUNX2, CDK6, NRF1, ARNT, BACH1, PBX4, SMAD4, ZNF518A, ZEB2, MAFB, FOS, HMGXB4, CDK8, MED1, ZEB1, TEAD3, MYB, SCRT2, PIAS1, SMAD1, ZBTB18, C11orf30, L3MBTL2, EVI1, SETDB1, MAFK, SP1, NIPBL, BCL11A, ASH2L, PHIP, FOXP1, SMC3, STAG2, STAG1, ZNF394, ZNF316, CBX3, FOXA2, PPARG, CHD2, ZNF600, ZSCAN16, GTF2B, ZNF692, MAFF, ZNF30, FOXF1, ZNF574, CDK9, HOXB13, ZNF580, KDM1A, YY1, RELA, HIF1A, GATA3, MGA, TAL1, MAX, ZNF143, HAND2, KLF4, BCL11B, ZNF592, SP7, TCF7L2, NEUROG2, KDM5B, TP53, ZNF687, ZSCAN22, EGR2, PHOX2B, ELF3, BRD2, KAT8, AR, ZBTB40, EGLN2, ZBTB42, HSF1, RNF2, JUND, ILF3, BRD4, MAZ, ZNF24, ZFP42, DMAP1, FOSL2

Target gene symbol (double-evidenced CRMs): APP,CYYR1,JAM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 10

Related genes and loops

Related gene: ENSG00000154721, ENSG00000142192, ENSG00000166265,

eachgene

Deatailed information for cohesin site CDBP00415304