- Basic information
- CohesinDB ID: CDBP00415564
- Locus: chr21-26801063-26801912
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Data sourse: ENCSR230ZWH, GSE138405, GSE165895, GSE206145, GSE206145-NatGen2015, ENCSR000EDE, GSE126990, GSE108869, ENCSR000ECS, ENCSR917QNE
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Cell type: RPE, Hela-Kyoto, Fibroblast, HeLa-S3, Liver, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.933
- Subunit: Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
41% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 55%,
"7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, PAX7, CHD8, SMARCA2, FOXA2, BRD3, ZSCAN5C, CEBPA, AFF4, CHD2, ZNF692, ZBTB17, ZSCAN21, MAFF, ZBTB12, FOXA1, SRF, HIC1, ZNF580, ZNF18, SMARCC1, TBP, YY1, PRDM10, RELA, ERG, HOXC5, RUNX2, OSR2, TSHZ1, RAD21, ZBTB44, PBX4, PRDM1, IKZF3, ZEB2, ZNF189, TAL1, STAT3, UBN1, MZF1, ZNF10, CDK8, MITF, ZSCAN4, MED1, NR3C1, MYOG, CEBPB, JMJD1C, NR2F2, ZXDB, TRIM28, PIAS1, NEUROG2, NFE2L2, PKNOX1, FEZF1, ZNF561, CTCF, BRD2, USF1, SP1, EP300, BAF155, JUN, AR, GATA6, GATA2, PRDM4, ZNF366, SIX2, ZHX1, FLI1, ZBTB42, BRD4, PHIP, JUND, PRDM6, ELL2, GTF2F1
- Target gene symbol (double-evidenced CRMs): APP,MRPL39,GABPA
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000154719,
ENSG00000154727,
ENSG00000142192,
- Related loop:
chr21:25300000-25325000~~chr21:26800000-26825000,
chr21:25575000-25600000~~chr21:26800000-26825000,
chr21:25775000-25800000~~chr21:26800000-26825000,
chr21:25950000-25975000~~chr21:26800000-26825000,
chr21:26150000-26175000~~chr21:26800000-26825000,
chr21:26375000-26400000~~chr21:26800000-26825000,
chr21:26800000-26825000~~chr21:28225000-28250000,
chr21:26800000-26825000~~chr21:28725000-28750000,
chr21:26800000-26825000~~chr21:28950000-28975000,