Deatailed information for cohesin site CDBP00416094

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  • Basic information
  • CohesinDB ID: CDBP00416094
  • Locus: chr21-29018321-29020227
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, ENCSR000BSB, GSE116868, ENCSR000EGW, ENCSR000BLY, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, GSE165895, ENCSR000DZP, GSE67783, ENCSR000BKV, GSE86191, GSE138405, GSE76893, GSE101921, GSE206145-NatGen2015, GSE120943, GSE130135, ENCSR703TNG, GSE106870, GSE116344, ENCSR000EEG, ENCSR338DUC, GSE98367, ENCSR879KXD, ENCSR000BLS, GSE206145, GSE62063, ENCSR000BMY, ENCSR000EHX, ENCSR167MTG, GSE129526, GSE111913, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE50893, GSE126755, ENCSR000ECS, GSE38411
  • Cell type: MDM, RH4, GM2610, OCI-AML-3, HSPC, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, RPE, GM2630, Fibroblast, GM12890, HeLa-S3, GM2255, BCBL-1, K-562, GM18486, DKO, HFFc6, H1-hESC, SNYDER, Monocytes, GM18505, MB157, GM12878, GM12891, GM2588, SK-N-SH, GM19239, RT-112, Macrophage, Ramos, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, A-549, HCAEC, GM19238, Neutrophil, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 19% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.511
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS,TES
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 72% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "2_TssAFlnk": 35%, "1_TssA": 33%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, E4F1, SOX5, E2F4, DEK, ZNF528, RFX3, ZNF555, KMT2B, GATAD2A, NANOG, POU5F1, BRD3, TOP2A, CTBP1, ERF, STAT1, ZNF134, SAP130, ERG, PAX6, ZBTB8A, NFKB2, EZH1, SMARCA4, TOP1, FOXK2, UBN1, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, NR2C2, MXI1, HCFC1, RELB, EP400, RUNX1, HDAC1, CEBPA, NKX2-2, CRY1, REPIN1, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ELK1, ATF2, FOXM1, SP2, SMARCB1, PML, PIAS1, SMAD1, IKZF5, ARID2, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, TCF4, ZFP36, BATF, SPIB, PLAG1, KLF4, BCL11B, ZFP69B, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, ZNF660, XBP1, KDM4B, PBX2, ATF3, THRB, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, MITF, CDC5L, JMJD1C, INTS11, MAF, ELF1, RBM39, KLF10, SMAD5, FUS, CTCF, TAF3, JUN, MNT, ZBTB20, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF423, PDX1, TFAP2C, RBPJ, MLX, ZSCAN21, ZBTB17, ZBTB48, MTA2, NONO, SRF, DDX5, NBN, KDM4A, ZNF2, FOXP2, HOMEZ, RXRA, NKX3-1, PRDM14, MIER3, LEF1, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, KDM5A, ZSCAN29, SMARCA5, NFIL3, CC2D1A, THAP11, AFF4, SOX13, ZNF770, ZMIZ1, ZNF18, ARNT, BACH1, ZNF48, HMBOX1, ZEB2, NFYA, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, DIDO1, ZXDB, ZNF680, U2AF1, TAF7, ZBTB18, KLF9, TBX5, USF1, BCL11A, SP1, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, MLLT1, STAG1, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, KDM1A, BRG1, ZIC2, GATA3, TAL1, ZNF143, MTA1, AGO2, CBX2, TP53, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, SPIN1, CUX1, ZSCAN23, ZFP42, CBX5, PGR, PATZ1, LEO1, UBTF, TFAP4, SIN3B, ZNF444, ATF4, MXD4, ZNF189, SMARCE1, RLF, KLF6, NFE2L2, SAP30, ESR1, SND1, KLF1, SOX4, E2F6, TRIM24, U2AF2, GTF2F1, GLIS1, POU2F2, ZNF778, KDM4C, ASH1L, ZSCAN5A, ELK4, ZMYND8, ERG2, SP4, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, SRSF3, EZH2, ZNF652, PHF8, SPI1, PCBP1, HDAC2, INTS13, GATAD2B, TAF9B, NCOA2, ZNF76, NFYB, ETV5, BCL6, SIN3A, ZFP37, ERG3, RARA, ZNF35, ZNF384, CREBBP, TAF15, NFYC, SMAD4, ZNF518A, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, GTF3C2, SREBF2, ZNF22, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, ZNF816, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, ZNF574, YY2, RELA, TARDBP, ZNF282, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, PKNOX1, AR, KMT2D, ZNF324, HEXIM1, AHR, DMAP1, FOSL2, ZNF391, HMG20A, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, SFMBT1, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, MLL, USF2, ZFP91, TCF12, BAF155, EP300, SOX6, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, ID3, GATAD1, ARID3A, MIER1, ZNF341, RAD21, GRHL3, PROX1, APC, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, ZNF501, HES1, TFE3, EHF, HBP1, IRF1, ZGPAT, MRTFB, MYF5, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, FIP1L1, ZNF534, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, GATA4, OSR2, ZNF184, NRF1, NR2C1, SUPT5H, CHD1, FOS, MED1, CEBPD, MYB, SCRT2, KDM6B, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, FOXA2, RBBP5, ZNF600, MIER2, ZBED1, ZBTB33, CDK9, HOXB13, YY1, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF449, GATA1, CEBPG, SP7, NR2F2, ZNF687, BHLHE40, NFKBIZ, TAF1, ZBTB40, ZBTB42, NOTCH3, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): USP16,LTN1,RWDD2B
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 21
  • Number of somatic mutations (non-coding): 15
  • Related genes and loops
  • Related gene: ENSG00000198862, ENSG00000156253, ENSG00000156256,
  • Related loop: chr21:17775000-17800000~~chr21:29000000-29025000, chr21:25325000-25350000~~chr21:29000000-29025000, chr21:25725000-25750000~~chr21:29000000-29025000, chr21:28991455-28993844~~chr21:29023842-29026326, chr21:28991517-28993800~~chr21:29024190-29026094, chr21:28991528-28993711~~chr21:29024204-29026148, chr21:28991579-28993764~~chr21:29023633-29025850, chr21:28991614-28993817~~chr21:29023881-29026318, chr21:28991626-28993358~~chr21:29018475-29019750, chr21:28991807-28993775~~chr21:29023855-29025783, chr21:29002049-29004026~~chr21:29018446-29019818, chr21:29025000-29050000~~chr21:31675000-31700000, chr21:29025000-29050000~~chr21:32325000-32350000, chr21:29025000-29050000~~chr21:32750000-32775000, chr21:29025000-29050000~~chr21:33525000-33550000,
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