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Basic information

CohesinDB ID: CDBP00416117

Locus: chr21-29087569-29094441

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, ENCSR000EEG, GSE130140, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CUTLL1, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HUVEC, HCAEC, Ramos, GM19238, HeLa, CNCC-WT33iPSC, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 79% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.189

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 72% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 33%, "15_Quies": 32%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, SOX2, XBP1, FOXA1, SUZ12, BMI1, ZFP64, ZNF362, ZBTB44, PRDM1, ZNF189, ZNF121, ETV1, ESR1, BAF155, PDX1, TFAP2C, GLIS1, NANOG, CHD8, POU2F2, POU5F1, RUNX1T1, CTBP1, ZSCAN21, ZBTB17, ZNF317, ZBTB48, ERG, SMARCA4, RFX1, GRHL3, NKX2-1, GABPA, XRCC5, NKX3-1, ESRRA, EBF3, SPI1, GATA2, MRTFB, ZNF554, RUNX1, ZNF335, SMAD3, CBX8, SMARCC1, PRDM10, ZNF384, CDK6, SMAD2, GATA4, OSR2, ZNF184, PBX4, PRDM9, ZNF22, NUP98-HOXA9, HOXA9, PHIP, PRDM6, FOXA2, EBF1, SS18, GTF2B, WT1, HOXB13, RELA, ISL1, ZFP36, HIF1A, OTX2, GATA3, GATA1, ZNF143, HAND2, CBX2, NR2F2, PKNOX1, ZNF334, PHOX2B, BRD2, AR, ZBTB40, RNF2

Target gene symbol (double-evidenced CRMs): MAP3K7CL,KRTAP19-1,BACH1,GRIK1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 398

Number of somatic mutations (non-coding): 72

Related genes and loops

Related gene: ENSG00000156265, ENSG00000156273, ENSG00000171189, ENSG00000184351,

eachgene

Deatailed information for cohesin site CDBP00416117