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Basic information

CohesinDB ID: CDBP00416121

Locus: chr21-29098256-29099251

Data sourse: GSE116344, GSE126755, ENCSR879KXD, GSE73207

Cell type: K-562, RH4, TF-1, Neutrophil

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 1% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.956

Subunit: SMC3,Rad21

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 72% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 47%, "5_TxWk": 37%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, FOXA1, PBX2, LYL1, NFIC, ATF4, SMARCE1, PAX5, MITF, CDX2, JMJD1C, INTS11, ELF1, TRIM28, LMO2, MLL, CTCF, TCF12, EP300, LMO1, GATA6, DPF2, TRIM24, SOX6, TEAD4, KMT2B, POU5F1, STAT1, MLLT3, DDX5, NBN, ERG, PBX1, MYC, SMARCA4, ARID1B, RAD21, GABPA, STAT3, NKX3-1, IKZF1, LEF1, NFE2, RCOR1, CEBPB, KMT2A, ZHX2, SPI1, GATA2, INTS13, ZSCAN29, FLI1, ZNF766, RUNX1, SMC1A, BCL6, HDAC1, CEBPA, SMARCC1, MEF2A, CREBBP, ZNF384, GATA4, ZNF48, ZEB2, HMBOX1, PBX3, CBFA2T3, FOXM1, FOS, CDK8, ETV6, CEBPD, MYB, ZMYM3, SMAD1, L3MBTL2, SETDB1, BCL11A, HNF4A, REST, TCF3, BCOR, SKI, MEF2B, FOXA2, CBX3, CREM, MEIS1, EBF1, GTF2B, MEF2C, ZBTB33, CDK9, KDM1A, YY1, RELA, JUNB, GATA3, TAL1, MAX, GATA1, CEBPG, NR2F2, TCF7L2, PKNOX1, MED, NFKB1, PHOX2B, AR, ZBTB16, ZBTB40, RXR, JUND, BRD4, ZNF24, FOSL2

Target gene symbol (double-evidenced CRMs): MAP3K7CL,GRIK1,BACH1,KRTAP19-1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 24

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000156265, ENSG00000156273, ENSG00000171189, ENSG00000184351,

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Deatailed information for cohesin site CDBP00416121