- Basic information
- CohesinDB ID: CDBP00416147
- Locus: chr21-29180907-29186165
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Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR000BLY, ENCSR150EFU, ENCSR000ECS, GSE103477, GSE108869, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE86191, GSE138405, GSE206145-NatGen2015, GSE120943, GSE138105, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE98367, ENCSR193NSH, ENCSR879KXD, GSE206145, ENCSR247LSH, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, GSE105004, ENCSR853VWZ, ENCSR956LGB, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR748MVX
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Cell type: MDM, SLK, Liver, HuCC-T1, RPE, Fibroblast, GM12890, HeLa-S3, IMR-90, K-562, HFFc6, Monocytes, SK-N-SH, RT-112, THP-1, Macrophage, MCF-7, Hela-Kyoto, HCT-116, Hep-G2, A-549, HUVEC, HeLa, Neutrophil
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 21% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.733
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
72% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"7_Enh": 31%,
"5_TxWk": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RELA, GATA6, HNF1B, GATA3, TAL1, CDK9, TFAP2C, DACH1
- Target gene symbol (double-evidenced CRMs): BACH1,MAP3K7CL,CCT8,TIAM1
- Function elements
- Human SNPs: Gamma_glutamyl_transferase_levels
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 32
- Related genes and loops
- Related gene:
ENSG00000156261,
ENSG00000156265,
ENSG00000156273,
ENSG00000156299,
- Related loop:
chr21:29075000-29100000~~chr21:29175000-29200000,
chr21:29124718-29126312~~chr21:29176363-29177502,
chr21:29175000-29200000~~chr21:29275000-29300000,
chr21:29175000-29200000~~chr21:29300000-29325000,
chr21:29175000-29200000~~chr21:29350000-29375000,
chr21:29175000-29200000~~chr21:31250000-31275000,
chr21:29181177-29183351~~chr21:29297767-29300990,
chr21:29181313-29182963~~chr21:29347735-29349361,