Deatailed information for cohesin site CDBP00416148

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  • Basic information
  • CohesinDB ID: CDBP00416148
  • Locus: chr21-29187616-29191797
  • Data sourse: ENCSR230ZWH, ENCSR000BSB, ENCSR501LQA, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, ENCSR000ECS, GSE131606, ENCSR330ELC, GSE108869, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE138405, GSE101921, ENCSR806UKK, GSE206145-NatGen2015, GSE120943, ENCSR199XBQ, ENCSR895JMI, GSE98367, ENCSR193NSH, ENCSR768DOX, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, GSE105004, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE129526, ENCSR676MJK, GSE111913, ENCSR335RKQ, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR748MVX
  • Cell type: Liver, HuCC-T1, RPE, Fibroblast, HeLa-S3, GM2255, IMR-90, K-562, HFFc6, DKO, Monocytes, SK-N-SH, RT-112, Macrophage, Hela-Kyoto, HCT-116, A-549, HCAEC, HeLa, Neutrophil
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 21% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.778
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True
  • Compartment: 72% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "15_Quies": 34%, "5_TxWk": 31%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, PGR, HMG20A, ZNF660, SOX2, NME2, HNF1A, XBP1, PATZ1, FOXA1, ZNF101, HLF, SUZ12, PBX2, RXRB, MLL4, HNRNPK, BMI1, ATF3, NFIC, ZFP64, CHD7, PRDM1, ZNF189, MECOM, TP63, ZSCAN4, CDX2, ZNF629, MAF, JMJD1C, SNAPC1, BCLAF1, TEAD1, KLF6, TRIM28, NFE2L2, KLF10, RCOR2, ESR1, HNF1B, MED26, ETV1, JUN, CTCF, TCF12, EP300, TAF3, BAF155, ZBTB20, KLF1, GATA6, DPF2, SOX4, IRF4, RFX5, SOX6, E2F1, ZNF528, SMC1, TEAD4, FOXA3, KMT2B, ZNF92, GATAD2A, PDX1, TFAP2C, EED, GTF2F1, POU2F2, CHD8, NANOG, MIER3, ZNF239, BRD3, TOP2A, ID3, MYCN, CTBP1, ZSCAN21, ZBTB17, ZBTB48, ZNF317, STAT1, RUNX1T1, DUX4, SRF, GATAD1, SAP130, ARID3A, TBP, HNF4G, ERG, HOXC5, ZNF341, ETS1, MYC, ONECUT1, SMARCA4, ZNF2, ARID1B, RAD21, POU5F1, GRHL3, RXRA, NKX2-1, FOXK2, PROX1, GABPA, STAT3, NKX3-1, IKZF1, RCOR1, NFE2, NR2F6, ZNF639, VDR, ARNTL, NR3C1, ESRRA, CEBPB, DACH1, ZNF416, KMT2A, CREB1, TBL1XR1, KLF8, GRHL2, FEZF1, EBF3, NFE2L1, ZHX2, SPI1, MIXL1, EHF, IRF1, HDAC2, GATA2, ZNF644, SIX2, FLI1, ZGPAT, RELB, MRTFB, NFIL3, ZNF554, ATF1, RUNX1, THAP11, SMC1A, ZBTB24, BCL6, CEBPA, MAFG, HDAC1, ZNF335, SIN3A, SOX13, AFF4, NKX2-2, SMAD3, ZFX, CBX8, SP5, SMARCC1, PRDM10, MEF2A, RARA, ZNF35, RUNX2, GATA4, ZNF184, PBX4, ARNT, NRF1, DAXX, BACH1, ZNF48, SMAD4, ZEB2, ZNF518A, ETV6, MAFB, FOXM1, CHD1, FOS, CDK8, PBX3, SMARCB1, MED1, ZEB1, TERF1, CEBPD, SPDEF, MYB, PIAS1, SMAD1, SUPT16H, NR1H2, KLF9, C11orf30, EVI1, SETDB1, KLF16, MAFK, BCL11A, SP1, USF1, HNF4A, NR4A1, REST, ARID1A, ZHX1, ASH2L, PHIP, AFF1, FOXP1, PRDM6, SMC3, ELL2, SKI, NELFA, PPARG, FOXA2, ZNF316, CREM, CHD2, NFATC1, CBX3, ZNF600, ZNF692, GTF2B, ZNF30, WT1, MAFF, FOXF1, ESR2, ZNF574, ZBTB33, MEF2C, CDK9, HOXB13, KDM1A, YY1, RELA, TARDBP, JUNB, ZFP36, HIF1A, TCF4, OTX2, GATA3, BATF, TAL1, MAX, NRIP1, GATA1, ZNF143, ZNF449, TLE3, KLF4, ZFP69B, SP7, CEBPG, NR2F2, TCF7L2, NR2F1, TP53, PKNOX1, NFKB1, ELF3, BRD2, KAT8, BHLHE40, AR, TAF1, ZBTB40, YAP1, ZNF324, RXR, ZNF366, HSF1, RNF2, ZBTB26, BRD4, JUND, ILF3, CLOCK, MAZ, ELF1, ZNF24, AHR, FOSL2
  • Target gene symbol (double-evidenced CRMs): BACH1,MAP3K7CL,CCT8,TIAM1
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 0
  • Number of somatic mutations (non-coding): 15
  • Related genes and loops
  • Related gene: ENSG00000156261, ENSG00000156265, ENSG00000156273, ENSG00000156299,
  • Related loop: chr21:29075000-29100000~~chr21:29175000-29200000, chr21:29175000-29200000~~chr21:29275000-29300000, chr21:29175000-29200000~~chr21:29300000-29325000, chr21:29175000-29200000~~chr21:29350000-29375000, chr21:29175000-29200000~~chr21:31250000-31275000, chr21:29181177-29183351~~chr21:29297767-29300990, chr21:29181313-29182963~~chr21:29347735-29349361, chr21:29195502-29197292~~chr21:29297767-29300990,
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