- Basic information
- CohesinDB ID: CDBP00416156
- Locus: chr21-29215632-29220031
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Data sourse: GSE206145-GSE177045, ENCSR230ZWH, GSE72082, ENCSR501LQA, ENCSR760NPX, ENCSR150EFU, ENCSR000ECS, GSE103477, GSE111537, GSE131606, ENCSR330ELC, GSE108869, ENCSR917QNE, ENCSR000EFJ, GSE165895, GSE138405, GSE76893, GSE101921, ENCSR806UKK, GSE206145-NatGen2015, GSE120943, ENCSR703TNG, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE98367, ENCSR193NSH, ENCSR768DOX, GSE206145, ENCSR981FDC, ENCSR247LSH, ENCSR807WAC, ENCSR620NWG, ENCSR767DFK, ENCSR495WGO, ENCSR984DZW, ENCSR217ELF, ENCSR000BTQ, GSE105004, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR000HPG, ENCSR676MJK, ENCSR335RKQ, ENCSR537EFT, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, GSE126755, ENCSR748MVX
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Cell type: MDM, OCI-AML-3, Liver, HuCC-T1, RPE, HMEC, Fibroblast, HeLa-S3, IMR-90, K-562, HFFc6, DKO, Monocytes, GM19239, Macrophage, MCF-7, Hela-Kyoto, A-549, HUVEC, HeLa, Neutrophil
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 30% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.767
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS,TES,Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
72% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"15_Quies": 52%,
"7_Enh": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: FOXO1, FOXA1, HLF, ZBTB44, IKZF3, TEAD1, ZNF121, LMO2, ZNF561, ZNF577, E2F4, ZNF528, KMT2B, GATAD2A, NANOG, ZNF263, TOP2A, CTBP1, STAT1, ZNF563, ZNF488, ERG, ZBTB21, ZBTB8A, SMARCA4, TOP1, FOXK2, ZNF398, RCOR1, CEBPB, CREB1, ZHX2, KLF17, GATA2, ZNF644, FLI1, ZNF785, MXI1, RUNX1, CEBPA, NKX2-2, HDAC1, ZNF654, SMARCC1, PRDM10, ZXDC, ZBTB10, ATF2, FOXM1, SP2, ZNF584, PML, PIAS1, NR1H2, STAT5A, OVOL3, AFF1, ELL2, NFATC3, ZSCAN18, CBX3, CREM, CHD2, SS18, ZSCAN16, WT1, MEF2C, NEUROD1, JUNB, ZFP36, TCF4, ZFP69B, KLF4, BCL11B, ZBTB6, BCL6B, EGR2, ELF3, RXR, EGLN2, ZNF366, HSF1, SCRT1, ADNP, ZNF316, FOSL1, SMARCA2, ZNF660, XBP1, ZNF101, PBX2, ATF3, ZFP64, ZSCAN4, MITF, JMJD1C, ELF1, SNAI2, KLF10, ZNF624, CTCF, JUN, ZBTB20, DPF2, ZNF423, TFAP2C, ZSCAN21, ZBTB17, ZNF317, ZBTB48, SRF, NBN, ZNF2, TSHZ1, FOXP2, RXRA, NKX3-1, LEF1, TERF2, MIER3, VDR, NR3C1, ESRRA, KMT2A, FOXK1, TBL1XR1, KLF8, GRHL2, EBF3, ZNF146, NFIL3, THAP11, ZBTB24, EZH2phosphoT487, AFF4, ZNF770, ZNF513, ZNF18, ZNF792, SP3, ARNT, DAXX, ZEB2, PBX3, ZNF10, ZXDB, ZNF37A, USF1, SP1, BCL11A, ATF7, ASH2L, CTBP2, PRDM6, ZNF623, SMC3, MLLT1, STAG2, ZNF394, MTA3, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, ZNF155, ZIC2, GATA3, TAL1, NRIP1, ZNF143, TP53, NFKB1, BRD2, EGR1, RNF2, JUND, BRD4, ZSCAN23, IRF9, PGR, PATZ1, TFAP4, CHD7, ATF4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, ZNF217, ESR1, ZNF524, SOX9, SOX4, TRIM24, RFX5, GLIS1, POU2F2, ZNF778, ZBTB1, ZSCAN5A, ELK4, ZMYND8, HIC1, ERG2, SP4, TBP, HOXC5, SMARCC2, ETS1, MYC, ARID1B, ZNF24, NKX2-1, GABPA, STAT3, IKZF1, MRTFA, SPI1, HDAC2, ZNF76, ZNF554, BCL6, SIN3A, ZBTB12, ERG3, RARA, ZNF35, CREBBP, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, SPDEF, NCOA1, MAFK, HNF4A, REST, ARID1A, ZHX1, FOXP1, NCOR2, ZNF34, PPARG, ZNF692, ZNF30, ZNF574, YY2, ZNF318, RELA, TARDBP, MAX, GFI1B, NEUROG2, TCF7L2, KDM5B, NR2F1, PKNOX1, MYOD1, AR, YAP1, ZNF324, RBAK, AHR, FOSL2, ZNF391, HMG20A, ZSCAN5C, E2F7, MEIS2, ZFHX2, ZNF529, INSM2, NFIC, PRDM1, CDX2, ZNF629, TRIM28, ETV1, HNF1B, USF2, TCF12, BAF155, EP300, ZNF302, PRDM4, SOX6, E2F1, SMC1, TEAD4, FOXA3, ZNF175, ID3, ARID3A, ASCL1, RAD21, PROX1, ZNF667, ZNF639, ARNTL, ZNF750, FEZF1, ZNF664, EHF, IRF1, MRTFB, ATF1, SMC1A, CBX1, ZNF335, ZFX, SMAD3, CBX8, RUNX2, SMAD2, GATA4, OSR2, ZNF184, PBX4, NRF1, FOS, CHD1, MED1, ZNF558, MYB, SCRT2, CEBPD, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, GLI2, POU2F3, PHIP, FOXA2, ZNF600, FOXF1, ZBTB33, CDK9, HOXB13, ZNF589, YY1, HIF1A, OTX2, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NR2F2, ZNF83, ZNF354C, ZNF213, ZNF843, ZFP28, BHLHE40, TAF1, ZNF579, ZBTB40, ZBTB42, MYNN, NOTCH3, CLOCK, MAZ, BRCA1
- Target gene symbol (double-evidenced CRMs): MAP3K7CL,CCT8
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 12
- Related genes and loops