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Basic information

CohesinDB ID: CDBP00416207

Locus: chr21-29345772-29351015

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE130140, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: GM2610, CUTLL1, B-cell, Fibroblast, GM12890, BCBL-1, HFFc6, SNYDER, GM18505, MB157, GM12878, SK-N-SH, GM19193, Ramos, MCF-7, Hela-Kyoto, HEK293T, HCAEC, OCI-AML-3, GM10847, SLK, GP5d, GM2630, HEKn, IMR-90, GM18486, DKO, H1-hESC, Monocytes, CNCCs-H9ESC, HeLa-Tet-On, THP-1, HUES64, HeLa, TC-71, Neutrophil, CVB-hiPSC, CVI-hiPSC, Liver, TC-32, H9-hESC, HeLa-S3, GM2255, GM18526, Lymphoblast, GM12891, GM2588, GBM39, GM19239, RT-112, Macrophage, GM12892, HCT-116, MCF-10A, Hep-G2, Neurons-H1, HUVEC, HSPC, HAP1, MDM, RH4, GM19240, Transformed-RPE1, HuCC-T1, RPE, HMEC, Ishikawa, K-562, Leukemia-SEM, HUES9, GM19099, T-47D, HL-60, A-549, GM19238, CNCC-WT33iPSC, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 80% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.122

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS,TES

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 68% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 52%, "7_Enh": 28%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, PGR, E2F7, PATZ1, FOXA1, LEO1, RXRB, PBX2, KDM3A, HDGF, LYL1, THRB, NFIC, BMI1, ATF3, ZNF362, CTCFL, RUNX3, ZBTB44, ZNF207, CBFB, ZNF273, MXD4, ZNF189, PAX5, ZNF467, MAF, JMJD1C, ZNF629, TEAD1, BCLAF1, TRIM28, RBM39, ELF1, ZNF121, NFE2L2, LMO2, ESR1, MLL, ZNF217, SNAI2, ETV1, ZNF561, JUN, TCF12, CTCF, EP300, BAF155, DPF2, TRIM24, IRF4, DEK, RAD51, PBX3, ZNF528, SMC1, ZNF350, TEAD4, KMT2B, FOXA3, ZNF175, GATAD2A, GTF2F1, RBPJ, EED, GLIS1, POU2F2, CHD8, ZNF425, ZNF263, POU5F1, RUNX1T1, ID3, MYCN, CTBP1, MTA2, ZSCAN21, DUX4, ZBTB17, STAT1, ZBTB48, ZNF205, MLLT3, SRF, GATAD1, NBN, ARID3A, SP4, HNF4G, ERG, ASCL1, ETS1, MYC, MYOG, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, FOXK2, GABPA, STAT3, XRCC5, ZNF614, APC, NKX3-1, IKZF1, NFE2, MIER3, RCOR1, NR2F6, ARNTL, VDR, NR3C1, CEBPB, ESRRA, KMT2A, CREB1, EZH2, ZNF652, EBF3, ZHX2, SPI1, MIXL1, TFE3, IRF1, INTS13, GATA2, ZNF644, GATAD2B, SSRP1, FLI1, DRAP1, ZGPAT, HCFC1, SMARCA5, RELB, NFIL3, MRTFB, ZNF554, MYF5, ETV5, RUNX1, THAP11, MAFG, SMC1A, CEBPA, NKX2-2, BCL6, CBX1, SOX13, ZFX, AFF4, SMAD3, ZNF654, ZNF770, TRIM22, SMARCC1, PRDM10, MEF2A, RARA, PRPF4, ZNF384, CREBBP, ZNF35, ZBTB2, RUNX2, IRF2, GATA4, OSR2, ZNF184, PBX4, BACH1, ARNT, CBX3, NFIB, HMGB2, PRDM9, ZNF48, ATF2, ZEB2, ETV6, FOXM1, ZNF10, SUPT5H, CDK8, FOS, HMGXB4, SMAD4, MED1, CBFA2T3, TEAD3, TERF1, DIDO1, MYB, PML, SCRT2, PIAS1, SUPT16H, SMAD1, ZNF680, ZXDB, C11orf30, EVI1, STAT5A, RBM22, MAFK, SP1, BCL11A, NIPBL, HNF4A, IKZF5, REST, ZBTB7A, ATF7, ZHX1, ASH2L, HNRNPLL, PHIP, TCF3, BCOR, FOXP1, SMC3, ELL2, MLLT1, STAG1, STAG2, NFATC3, SKI, MEF2B, PPARG, FOXA2, MTA3, EBF1, CREM, PAF1, E2F8, NFATC1, ZNF692, GTF2B, MAFF, ZBED1, ZNF600, FOXF1, WT1, MEF2C, ZBTB33, CDK9, ZNF580, BCL3, HOXB13, KDM1A, YY1, RELA, TARDBP, NEUROD1, AHR, JUNB, SP140, TCF4, HIF1A, SKIL, OTX2, GATA3, BATF, TAL1, MAX, SPIB, ZNF143, AGO2, GATA1, CEBPG, KLF4, ZFP69B, GFI1B, NR2F2, ZNF544, NEUROG2, KDM5B, ZNF687, TP53, PKNOX1, ZBTB6, MED, ZNF334, ZSCAN22, MYOD1, BCL6B, ELF3, BRD2, TBX21, BHLHE40, AR, RXR, ZNF324, EGLN2, RB1, ZBTB26, HSF1, IKZF2, BRD4, JUND, ILF3, SCRT1, MAZ, ZNF440, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): CCT8,MAP3K7CL,GRIK1,BACH1

Function elements

Human SNPs: Aspartate_aminotransferase_levels

Number of somatic mutations (coding): 16

Number of somatic mutations (non-coding): 21

Related genes and loops

Related gene: ENSG00000156261, ENSG00000156265, ENSG00000156273, ENSG00000171189,

eachgene

Deatailed information for cohesin site CDBP00416207