- Basic information
- CohesinDB ID: CDBP00416208
- Locus: chr21-29351420-29352466
-
Data sourse: ENCSR000EFJ, GSE206145-NatGen2015, GSE206145, GSE165895
-
Cell type: RPE, Fibroblast, IMR-90, HFFc6
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 3% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.956
- Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2
-
CTCF binding site: CTCF
CTCF motif: False
- Genomic location: TSS
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
-
Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
-
Chromatin annotation:
"5_TxWk": 61%,
"4_Tx": 12%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
-
Co-bound Transcriptional factors: FOXO1, NFIA, PGR, E2F7, PATZ1, FOXA1, LEO1, RXRB, PBX2, KDM3A, HDGF, LYL1, THRB, NFIC, BMI1, ATF3, ZNF362, CTCFL, RUNX3, ZBTB44, ZNF207, CBFB, ZNF273, MXD4, ZNF189, PAX5, ZNF467, MAF, JMJD1C, ZNF629, TEAD1, BCLAF1, TRIM28, RBM39, ELF1, ZNF121, NFE2L2, LMO2, ESR1, MLL, ZNF217, SNAI2, ETV1, ZNF561, JUN, TCF12, CTCF, EP300, BAF155, DPF2, TRIM24, IRF4, DEK, RAD51, PBX3, ZNF528, SMC1, ZNF350, TEAD4, KMT2B, FOXA3, ZNF175, GATAD2A, GTF2F1, RBPJ, EED, GLIS1, POU2F2, CHD8, ZNF425, ZNF263, POU5F1, RUNX1T1, ID3, MYCN, CTBP1, MTA2, ZSCAN21, DUX4, ZBTB17, STAT1, ZBTB48, ZNF205, MLLT3, SRF, GATAD1, NBN, ARID3A, SP4, HNF4G, ERG, ASCL1, ETS1, MYC, MYOG, SMARCA4, HOMEZ, RAD21, GRHL3, RXRA, NKX2-1, FOXK2, GABPA, STAT3, XRCC5, ZNF614, APC, NKX3-1, IKZF1, NFE2, MIER3, RCOR1, NR2F6, ARNTL, VDR, NR3C1, CEBPB, ESRRA, KMT2A, CREB1, EZH2, ZNF652, EBF3, ZHX2, SPI1, MIXL1, TFE3, IRF1, INTS13, GATA2, ZNF644, GATAD2B, SSRP1, FLI1, DRAP1, ZGPAT, HCFC1, SMARCA5, RELB, NFIL3, MRTFB, ZNF554, MYF5, ETV5, RUNX1, THAP11, MAFG, SMC1A, CEBPA, NKX2-2, BCL6, CBX1, SOX13, ZFX, AFF4, SMAD3, ZNF654, ZNF770, TRIM22, SMARCC1, PRDM10, MEF2A, RARA, PRPF4, ZNF384, CREBBP, ZNF35, ZBTB2, RUNX2, IRF2, GATA4, OSR2, ZNF184, PBX4, BACH1, ARNT, CBX3, NFIB, HMGB2, PRDM9, ZNF48, ATF2, ZEB2, ETV6, FOXM1, ZNF10, SUPT5H, CDK8, FOS, HMGXB4, SMAD4, MED1, CBFA2T3, TEAD3, TERF1, DIDO1, MYB, PML, SCRT2, PIAS1, SUPT16H, SMAD1, ZNF680, ZXDB, C11orf30, EVI1, STAT5A, RBM22, MAFK, SP1, BCL11A, NIPBL, HNF4A, IKZF5, REST, ZBTB7A, ATF7, ZHX1, ASH2L, HNRNPLL, PHIP, TCF3, BCOR, FOXP1, SMC3, ELL2, MLLT1, STAG1, STAG2, NFATC3, SKI, MEF2B, PPARG, FOXA2, MTA3, EBF1, CREM, PAF1, E2F8, NFATC1, ZNF692, GTF2B, MAFF, ZBED1, ZNF600, FOXF1, WT1, MEF2C, ZBTB33, CDK9, ZNF580, BCL3, HOXB13, KDM1A, YY1, RELA, TARDBP, NEUROD1, AHR, JUNB, SP140, TCF4, HIF1A, SKIL, OTX2, GATA3, BATF, TAL1, MAX, SPIB, ZNF143, AGO2, GATA1, CEBPG, KLF4, ZFP69B, GFI1B, NR2F2, ZNF544, NEUROG2, KDM5B, ZNF687, TP53, PKNOX1, ZBTB6, MED, ZNF334, ZSCAN22, MYOD1, BCL6B, ELF3, BRD2, TBX21, BHLHE40, AR, RXR, ZNF324, EGLN2, RB1, ZBTB26, HSF1, IKZF2, BRD4, JUND, ILF3, SCRT1, MAZ, ZNF440, ZNF316, FOSL2
- Target gene symbol (double-evidenced CRMs): CCT8,GRIK1,MAP3K7CL
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 4
- Related genes and loops
- Related gene:
ENSG00000156261,
ENSG00000156265,
ENSG00000171189,
- Related loop:
chr21:29075000-29100000~~chr21:29325000-29350000,
chr21:29075000-29100000~~chr21:29350000-29375000,
chr21:29089019-29091765~~chr21:29347581-29349365,
chr21:29089067-29091786~~chr21:29347632-29349367,
chr21:29089072-29091405~~chr21:29347617-29349359,
chr21:29089160-29091117~~chr21:29347755-29349310,
chr21:29089167-29091099~~chr21:29347660-29349347,
chr21:29089188-29091090~~chr21:29347684-29349339,
chr21:29089226-29091194~~chr21:29347657-29349380,
chr21:29089236-29091115~~chr21:29347637-29349372,
chr21:29089247-29091085~~chr21:29347692-29349326,
chr21:29089253-29091784~~chr21:29347649-29349937,
chr21:29089253-29091866~~chr21:29347600-29349350,
chr21:29089261-29091354~~chr21:29347652-29349375,
chr21:29089274-29091757~~chr21:29347569-29349367,
chr21:29089288-29091868~~chr21:29347684-29349364,
chr21:29089299-29091014~~chr21:29347749-29349306,
chr21:29089315-29091812~~chr21:29347653-29349368,
chr21:29089332-29090990~~chr21:29347656-29349372,
chr21:29089350-29091002~~chr21:29347655-29349349,
chr21:29089353-29091857~~chr21:29347586-29349777,
chr21:29089362-29091799~~chr21:29347653-29349341,
chr21:29089364-29091181~~chr21:29347677-29349847,
chr21:29089382-29091075~~chr21:29347811-29349358,
chr21:29089486-29091829~~chr21:29347582-29349316,
chr21:29089531-29091070~~chr21:29347741-29349366,
chr21:29089580-29091034~~chr21:29347821-29349746,
chr21:29091949-29093553~~chr21:29347639-29349364,
chr21:29091975-29093600~~chr21:29347653-29349368,
chr21:29092103-29093370~~chr21:29347649-29349937,
chr21:29100000-29125000~~chr21:29350000-29375000,
chr21:29150000-29175000~~chr21:29325000-29350000,
chr21:29150000-29175000~~chr21:29350000-29375000,
chr21:29162305-29165453~~chr21:29347649-29349937,
chr21:29162316-29165407~~chr21:29347639-29349336,
chr21:29162347-29165506~~chr21:29347569-29349367,
chr21:29162378-29165498~~chr21:29347586-29349777,
chr21:29163284-29165488~~chr21:29347632-29349367,
chr21:29163333-29165304~~chr21:29347811-29349358,
chr21:29163439-29165245~~chr21:29347811-29349339,
chr21:29163509-29165242~~chr21:29347678-29349344,
chr21:29163629-29165264~~chr21:29347677-29349365,
chr21:29163714-29165477~~chr21:29347632-29349309,
chr21:29163725-29165459~~chr21:29347656-29349372,
chr21:29163734-29165276~~chr21:29347684-29349339,
chr21:29163746-29165675~~chr21:29347638-29349313,
chr21:29163756-29165286~~chr21:29347699-29349347,
chr21:29163801-29165267~~chr21:29347792-29349359,
chr21:29163801-29165269~~chr21:29347138-29349317,
chr21:29175000-29200000~~chr21:29350000-29375000,
chr21:29181313-29182963~~chr21:29347735-29349361,
chr21:29225000-29250000~~chr21:29325000-29350000,
chr21:29225000-29250000~~chr21:29350000-29375000,
chr21:29232431-29234308~~chr21:29347637-29349372,
chr21:29267340-29269377~~chr21:29347233-29349373,
chr21:29347639-29349364~~chr21:29848859-29851155,
chr21:29350000-29375000~~chr21:29450000-29475000,
chr21:29350000-29375000~~chr21:29475000-29500000,
chr21:29350000-29375000~~chr21:29675000-29700000,
chr21:29350000-29375000~~chr21:29800000-29825000,
chr21:29350000-29375000~~chr21:29825000-29850000,
chr21:29350000-29375000~~chr21:29850000-29875000,
chr21:29350000-29375000~~chr21:30175000-30200000,
chr21:29350000-29375000~~chr21:31075000-31100000,