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Basic information

CohesinDB ID: CDBP00416239

Locus: chr21-29475468-29478798

Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE51234, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE132649, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, ShirahigeLab, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE73207, ShirahigeLab-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, ShirahigeLab-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE155828, ENCSR981FDC, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990

Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, Transformed-RPE1, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, Leukemia-SEM, MB157, Lymphoblast, TF-1, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, CNCCs-H9ESC, GM19193, HeLa-Tet-On, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, T-47D, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, TC-71, Neutrophil, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 78% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.133

Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 68% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 47%, "7_Enh": 21%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, FOSL1, CBX5, PGR, ZNF660, SOX2, MEIS2, XBP1, ZNF101, FOXA1, RBFOX2, RXRB, PBX2, KDM3A, HDGF, ZNF362, CTCFL, RUNX3, PRDM1, THAP1, ZNF444, HNRNPUL1, CBFB, SMARCE1, PAX5, TP63, ZNF629, JMJD1C, MAF, TEAD1, BCLAF1, TRIM28, ELF1, KLF6, NFE2L2, ZNF217, ESR1, RCOR2, TP73, CTCF, JUN, TCF12, BAF155, EP300, KLF1, SOX5, DPF2, IRF4, RFX5, TRIM24, SOX6, DEK, CEBPA, E2F1, SMC1, TEAD4, FOXA3, ZNF175, GATAD2A, GTF2F1, TFAP2C, EED, RBPJ, GLIS1, PDX1, EHMT2, POU2F2, CHD8, NANOG, POU5F1, MTA2, ZBTB17, ZBTB48, DUX4, STAT1, SRF, GATAD1, SAP130, NBN, ARID3A, TBP, ERG, HOXC5, PBX1, MYC, SMARCA4, ARID1B, RAD21, HOMEZ, GRHL3, RXRA, NKX2-1, FOXK2, STAT3, XRCC5, ZNF614, NKX3-1, IKZF1, RCOR1, NFE2, NR2F6, MIER3, LEF1, NFRKB, NR3C1, ESRRA, CEBPB, ARNTL, KMT2A, CREB1, TBL1XR1, GRHL2, EBF3, GABPB1, ZHX2, SPI1, MIXL1, HDAC2, GATA2, ZNF644, FLI1, DRAP1, ZGPAT, NFIL3, MRTFB, ZNF554, ATF1, PTBP1, CC2D1A, RUNX1, THAP11, SMC1A, BCL6, MAFG, NKX2-2, CBX1, HDAC1, AFF4, SOX13, SIN3A, ZNF335, ZFX, SMAD3, ZNF654, TRIM22, ZNF18, SMARCC1, PRDM10, TWIST1, ZBTB2, ZNF384, ZNF35, CREBBP, RARA, BRD9, RUNX2, GATA4, OSR2, ZNF184, ARNT, DAXX, ZNF48, ATF2, SMAD4, NFYA, ZEB2, FOXM1, MAFB, CBFA2T3, PBX3, HMGXB4, CDK8, MED1, TEAD3, ZEB1, SCRT2, PIAS1, NR1H2, NCOA1, C11orf30, L3MBTL2, KLF16, ZNF22, MAFK, SP1, BCL11A, HNF4A, NR4A1, ARID2, IKZF5, ZNF479, REST, RBM25, ZHX1, ATF7, ASH2L, PHIP, AFF1, BCOR, FOXP1, TCF3, PRDM6, SMC3, ELL2, STAG2, STAG1, MLLT1, ZNF394, SKI, NFATC3, PAX7, MEF2B, PPARG, CBX3, ZNF17, EBF1, CREM, MEIS1, FOXA2, ZNF600, MIER2, ZNF692, WT1, MAFF, ZNF574, MEF2C, TCF7, CDK9, ZNF580, HOXB13, KDM1A, YY1, RELA, TARDBP, JUNB, AHR, ZNF148, CHAMP1, HIF1A, OTX2, GATA3, BATF, MAX, ZNF143, ZFP69B, ZNF592, SP7, GFI1B, NR2F2, BCL11B, KLF4, NR2F1, TCF7L2, KDM5B, TP53, PKNOX1, ELF3, TBX21, ARID4B, AR, BHLHE40, TAF1, ZNF579, ZBTB40, PAX3-FOXO1, ZNF324, EGLN2, ZNF366, HEXIM1, ZBTB26, NCOR1, HSF1, BRD4, JUND, IKZF2, MAZ, ZNF24, ADNP, ZNF316, FOSL2

Target gene symbol (double-evidenced CRMs): BACH1,CCT8,GRIK1,MAP3K7CL

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000156261, ENSG00000156265, ENSG00000156273, ENSG00000171189,

eachgene

Deatailed information for cohesin site CDBP00416239