- Basic information
- CohesinDB ID: CDBP00416245
- Locus: chr21-29499024-29500817
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR000DYE, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE67783, GSE86191, GSE101921, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR807WAC, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
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Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, HSPC, CVI-hiPSC, Liver, TC-32, HuCC-T1, H9-hESC, RPE, GM2630, HMEC, Fibroblast, HEKn, Ishikawa, Kelly, GM12890, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, MCF-7, GM12892, THP-1, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, A-549, HUVEC, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, TC-71, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 66% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.256
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: TSS,TES
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
53% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 66%,
"9_Het": 17%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: NFIA, CBX5, ZNF660, SOX2, NME2, PATZ1, FOXA1, RXRB, ATF3, NFIC, ZFP64, CTCFL, CHD7, MXD4, MZF1, ZNF736, TEAD1, TRIM28, ZNF121, ZNF557, KLF6, NFE2L2, LMO2, ESR1, RCOR2, OCA2, CTCF, TCF12, JUN, EP300, BAF155, GATA6, SOX5, DPF2, TRIM24, RFX5, DEK, ZNF528, SMC1, ZNF280A, TEAD4, FOXA3, GATAD2A, RBPJ, TFAP2C, NANOG, CHD8, BRD1, ZSCAN5D, POU5F1, ZNF263, TOP2A, MYCN, ZSCAN21, ZNF317, ZBTB48, SRF, GATAD1, SAP130, ARID3A, SP4, ERG, HOXC5, USP7, HOMEZ, RAD21, RXRA, GABPA, STAT3, ZNF614, XRCC5, NKX3-1, IKZF1, MIER3, RCOR1, NFE2, NR2F6, ARNTL, VDR, CEBPB, CREB1, EZH2, GABPB1, ZHX2, SPI1, MIXL1, IRF1, HDAC2, ZNF644, MXD3, FLI1, DRAP1, ZGPAT, HCFC1, MRTFB, ZNF554, ETV5, CC2D1A, RUNX1, THAP11, CBX1, SMC1A, HDAC1, CEBPA, BCL6, SOX13, ZFX, AFF4, FIP1L1, SMAD3, ZNF654, ERG3, TRIM22, SMARCC1, PRDM10, TWIST1, ZNF701, ZBTB2, ZNF35, ZNF384, PRPF4, RUNX2, GATA4, ZNF184, NRF1, ZNF48, ATF2, ZEB2, SMAD4, NFYA, FOXM1, SP2, SMARCB1, CDK8, HMGXB4, CHD1, MED1, GMEB1, TEAD3, ZXDB, PIAS1, SMAD1, SETDB1, USF1, BCL11A, IKZF5, REST, ZNF479, ZBTB7A, ZHX1, HNRNPLL, FOXP1, SMC3, ELL2, STAG1, STAG2, PPARG, CBX3, TBL1X, AGO1, EBF1, WT1, ZNF574, ZBTB33, MEF2C, ZNF580, HOXB13, KDM1A, YY1, RELA, NEUROD1, CHAMP1, SP140, HIF1A, GATA3, ZNF519, BATF, MAX, GATA1, ZNF143, CEBPG, ZNF592, GFI1B, NCOA3, TCF7L2, KDM5B, TP53, ZNF334, ELF3, BRD2, KAT8, ARRB1, ARID4B, AR, EGR1, HSF1, NOTCH3, BRD4, JUND, MAZ, ZNF24, AHR
- Target gene symbol (double-evidenced CRMs): MAP3K7CL,GRIK1,CCT8,BACH1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 2
- Related genes and loops
- Related gene:
ENSG00000156261,
ENSG00000156265,
ENSG00000156273,
ENSG00000171189,
- Related loop:
chr21:29075000-29100000~~chr21:29475000-29500000,
chr21:29076937-29078408~~chr21:29504618-29505774,
chr21:29089074-29091748~~chr21:29498802-29501235,
chr21:29150000-29175000~~chr21:29475000-29500000,
chr21:29163806-29165395~~chr21:29499245-29500556,
chr21:29350000-29375000~~chr21:29475000-29500000,
chr21:29475000-29500000~~chr21:29625000-29650000,
chr21:29475000-29500000~~chr21:29675000-29700000,
chr21:29475000-29500000~~chr21:29800000-29825000,
chr21:29475000-29500000~~chr21:29825000-29850000,
chr21:29475000-29500000~~chr21:29850000-29875000,
chr21:29475000-29500000~~chr21:30175000-30200000,
chr21:29475000-29500000~~chr21:31075000-31100000,
chr21:29498758-29500987~~chr21:29848871-29851131,
chr21:29498761-29501306~~chr21:29848799-29851068,
chr21:29498762-29500871~~chr21:29848836-29851040,
chr21:29498791-29500809~~chr21:29848901-29851051,
chr21:29498877-29501050~~chr21:29848873-29851025,
chr21:29498889-29500781~~chr21:29848945-29850681,
chr21:29498908-29500997~~chr21:29848886-29851009,
chr21:29498988-29500641~~chr21:29848938-29850670,
chr21:29498988-29500813~~chr21:29848796-29851053,
chr21:29499107-29500791~~chr21:29848789-29851052,
chr21:29499126-29500820~~chr21:29848754-29850764,
chr21:29499131-29500921~~chr21:29848787-29851050,
chr21:29500000-29525000~~chr21:29650000-29675000,
chr21:29500000-29525000~~chr21:29675000-29700000,
chr21:29500000-29525000~~chr21:29800000-29825000,
chr21:29500000-29525000~~chr21:29825000-29850000,