- Basic information
- CohesinDB ID: CDBP00416335
- Locus: chr21-30044217-30045461
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Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE139435, GSE93080, GSE101921, ENCSR806UKK, GSE51234, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, ENCSR895JMI, GSE118494, ENCSR000EEG, GSE115248, ENCSR247LSH, GSE105004, ENCSR676MJK, GSE155324, ENCSR054FKH, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, ENCSR000BTQ, GSE129526, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE122299, GSE115250, GSE76893, GSE145327, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE131956, GSE110061, ENCSR000HPG, ENCSR335RKQ, ENCSR000EDE, GSE50893, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE152721, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, GSE68388, GSE126990
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Cell type: MDM, GM2610, SLK, CVB-hiPSC, GM19240, Liver, GP5d, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, HMEC, Fibroblast, RPE, HEKn, THP-1, Ishikawa, Kelly, GM12890, HeLa-S3, GM2255, IMR-90, K-562, GM18486, DKO, GM18526, H1-hESC, SNYDER, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, HAP1, Macrophage, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, HCAEC, GM19238, HeLa, CNCC-WT33iPSC, TC-71, OCI-AML-3, GM18951
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 52% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.311
- Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,SMC3
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CTCF binding site: CTCF
CTCF motif: True
- Genomic location: Intergenic
- 3D genome
- TAD boundary: Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: True
ChIA-PET loops: True
- Compartment:
24% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): False
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Chromatin annotation:
"15_Quies": 96%,
"9_Het": 2%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: POU2F2, SMC1A, CBX1, FOXA2, NKX2-2, SOX2, STAG2, ZSCAN21, SMAD3, FOXA1, FOXF1, SRF, ZNF654, CDK9, TRIM22, HOXB13, ERG, HNRNPK, ZBTB2, ZNF35, ZNF384, MYC, GATA4, RAD21, NKX2-1, FOXK2, OTX2, GABPA, FOS, ZNF143, MED1, CEBPB, CREB1, PIAS1, SMAD1, STAG1, KDM5B, ESR1, KLF16, CTCF, JUN, BAF155, HNF4A, AR, REST, GATA2, IRF4, BRD4, ILF3, FOXP1, E2F1, SMC1, SMC3, PDX1
- Target gene symbol (double-evidenced CRMs): CCT8,MAP3K7CL,GRIK1
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 0
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000156261,
ENSG00000156265,
ENSG00000171189,
- Related loop:
chr21:29075000-29100000~~chr21:30025000-30050000,
chr21:29475556-29477615~~chr21:30043860-30045602,
chr21:29675000-29700000~~chr21:30025000-30050000,
chr21:29900000-29925000~~chr21:30050000-30075000,
chr21:29925000-29950000~~chr21:30025000-30050000,
chr21:30025000-30050000~~chr21:30175000-30200000,
chr21:30025000-30050000~~chr21:30250000-30275000,
chr21:30025000-30050000~~chr21:30400000-30425000,
chr21:30025000-30050000~~chr21:30500000-30525000,
chr21:30025000-30050000~~chr21:31075000-31100000,
chr21:30025000-30050000~~chr21:31600000-31625000,
chr21:30043489-30045655~~chr21:30194059-30195711,
chr21:30043506-30045681~~chr21:30408230-30409738,
chr21:30043634-30045679~~chr21:30194094-30195702,
chr21:30043637-30045675~~chr21:30194049-30195562,
chr21:30043654-30045703~~chr21:30433235-30435097,
chr21:30043713-30045634~~chr21:30257148-30259258,
chr21:30043752-30045664~~chr21:30194049-30195711,
chr21:30043756-30045614~~chr21:30193229-30195738,
chr21:30043756-30045614~~chr21:30257090-30259197,
chr21:30043767-30045627~~chr21:30193927-30195724,
chr21:30043774-30045603~~chr21:30257103-30259279,
chr21:30043774-30045603~~chr21:30433524-30435077,
chr21:30043827-30045692~~chr21:30193829-30195709,
chr21:30043897-30045697~~chr21:30256685-30258690,
chr21:30043934-30045661~~chr21:30463362-30464553,
chr21:30043955-30045406~~chr21:30194162-30195586,
chr21:30043991-30045406~~chr21:30194144-30195644,
chr21:30044042-30045658~~chr21:30194075-30195765,
chr21:30050000-30075000~~chr21:30150000-30175000,
chr21:30050000-30075000~~chr21:30175000-30200000,
chr21:30050000-30075000~~chr21:30400000-30425000,
chr21:30050000-30075000~~chr21:31075000-31100000,
chr21:30050000-30075000~~chr21:31575000-31600000,
chr21:30050000-30075000~~chr21:31600000-31625000,