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Basic information

CohesinDB ID: CDBP00416349

Locus: chr21-30193663-30195325

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, ENCSR000FAD, GSE72082, ENCSR501LQA, GSE116868, ENCSR000EGW, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, ENCSR000EDW, GSE25021, ENCSR000BUC, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE115602, ENCSR000DZP, ENCSR000EAC, GSE139435, ENCSR000BKV, GSE115250, GSE122299, GSE138405, GSE143937, GSE76893, GSE101921, GSE152721, GSE206145-NatGen2015, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR703TNG, GSE106870, GSE138105, GSE145327, GSE93080, ENCSR895JMI, ENCSR000EEG, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR000ECE, GSE62063, GSE206145, ENCSR000EHX, ENCSR984DZW, GSE97394, GSE55407, ENCSR000BTQ, GSE105004, ENCSR167MTG, GSE131956, GSE110061, GSE129526, GSE111913, GSE155324, ENCSR335RKQ, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE126990, GSE50893, ENCSR000ECS, GSE131577

Cell type: MDM, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, CVI-hiPSC, Liver, HuCC-T1, H9-hESC, GM2630, HMEC, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, GM2255, IMR-90, K-562, DKO, GM18526, H1-hESC, SNYDER, GM18505, Leukemia-SEM, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, A-549, GM19238, HeLa, CNCC-WT33iPSC, TC-71, OCI-AML-3, GM18951

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 37% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.344

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,SMC3

CTCF binding site: CTCF CTCF motif: True

Genomic location: Intergenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 24% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "15_Quies": 90%, "14_ReprPCWk": 7%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: AR, GATA6, CEBPB, GATA2, TEAD1, FOXA2, XBP1, FOXA1, SETDB1, CTCF, AHR

Target gene symbol (double-evidenced CRMs): CCT8,GRIK1,BACH1,MAP3K7CL

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 11

Related genes and loops

Related gene: ENSG00000156261, ENSG00000156265, ENSG00000156273, ENSG00000171189,

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Deatailed information for cohesin site CDBP00416349