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Basic information

CohesinDB ID: CDBP00414005

Locus: chr21-17610934-17613664

Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, GSE126634, GSE116868, ENCSR000BLY, ENCSR404BPV, GSE105028, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000EAC, GSE67783, ENCSR000BKV, GSE115250, GSE138405, GSE86191, GSE101921, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE130135, GSE116344, GSE106870, GSE118494, ENCSR000EEG, ENCSR338DUC, ENCSR879KXD, ENCSR000BLS, GSE206145, GSE85526, GSE62063, ENCSR247LSH, ENCSR000EHX, ENCSR167MTG, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, ENCSR054FKH, ENCSR000EDE, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE38411

Cell type: MDM, RH4, GM10847, GM2610, OCI-AML-3, HSPC, CVI-hiPSC, Liver, TC-32, HuCC-T1, H9-hESC, B-cell, GM2630, RPE, Fibroblast, HEKn, Ishikawa, HeLa-S3, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, H1-hESC, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM2588, SK-N-SH, RT-112, Ramos, MCF-7, GM12892, Hela-Kyoto, HCT-116, HEK293T, Hep-G2, Neurons-H1, A-549, HCAEC, GM19238, Neutrophil, HAP1

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 25% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.467

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: TSS

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 60% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): False

Chromatin annotation: "2_TssAFlnk": 36%, "1_TssA": 33%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, TEAD1, ZNF121, PITX3, HDAC8, ZNF561, SOX5, E2F4, DEK, KMT2B, GATAD2A, NANOG, ZNF263, POU5F1, TOP2A, BRD3, CTBP1, DUX4, STAT1, SAP130, ERG, ZBTB21, SMARCA4, ZNF8, RCOR1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, GATA2, ZNF644, MXD3, FLI1, HCFC1, DRAP1, MXI1, RELB, EP400, RUVBL2, RUNX1, ZMYM2, HDAC1, CEBPA, SP5, TRIM22, SMARCC1, PRDM10, TFDP1, ATF2, FOXM1, SP2, SMARCB1, PML, SMAD1, MBD1, IKZF5, ARID2, RBM25, AFF1, MBD2, HMGB1, ETV4, NFATC3, MEF2B, CBX3, ZNF207, CREM, CHD2, PAF1, SS18, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, BATF, PLAG1, BCL11B, ZBTB6, MED, EGR2, ELF3, RBM14, ZNF765, ARID4B, ZNF366, ZBTB26, SCRT1, ILF3, FOSL1, ZNF660, KDM4B, ZNF101, PBX2, SRSF4, ZNF596, HNRNPK, ATF3, ZFP64, RUNX3, CBFB, TP63, ZSCAN4, ZNF467, INTS11, ELF1, RBM39, KLF10, SMAD5, FUS, JUN, CTCF, L3MBTL4, LMO1, MNT, DPF2, RYBP, IRF4, ZNF677, TFAP2C, RBPJ, MLX, ZNF317, ZSCAN21, ZBTB17, MTA2, ZBTB48, NONO, SRF, NBN, CHD4, TSHZ1, HOMEZ, KDM4A, FOXP2, RXRA, MIER3, HNRNPH1, VDR, NR3C1, KMT2A, ZBTB11, TBL1XR1, KLF8, ZBTB14, SSRP1, ZNF146, SMARCA5, NFIL3, THAP11, EZH2phosphoT487, SOX13, ZMIZ1, ZNF18, ARNT, BACH1, ZNF48, PRDM9, PBX3, NCAPH2, ZNF10, HMGXB4, TEAD3, DIDO1, ZNF680, U2AF1, TAF7, KLF9, TBX5, USF1, SP1, BCL11A, NKX2-5, ZNF479, ATF7, ASH2L, CTBP2, GLIS2, SMC3, STAT2, MLLT1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, ZNF580, ZKSCAN1, KDM1A, BRG1, PCGF1, GATA3, ZNF143, AGO2, TP53, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, SPIN1, PGR, PATZ1, LEO1, UBTF, RING1B, TFAP4, SIN3B, CHD7, ATF4, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, ZNF217, ESR1, KLF1, ZNF695, ZNF260, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5A, ELK4, ZMYND8, HIC1, ERG2, SP4, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, ZNF24, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, INO80, DNMT3B, SRSF3, EZH2, ZNF652, PHF8, SPI1, ZNF786, ZNF202, PCBP1, HDAC2, INTS13, ZNF182, GATAD2B, ZNF777, ETV5, ZNF566, BCL6, SIN3A, ZBTB12, ZFP37, ERG3, MEF2A, MYBL2, RARA, ZNF384, ZNF35, CREBBP, TAF15, NFYC, SMAD4, ZNF518A, ZEB1, ZMYM3, SUPT16H, NCOA1, SREBF2, RBM22, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, AATF, ZNF34, PPARG, HDAC6, ZNF692, ZNF574, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, TCF7L2, NR2F1, KDM5B, PKNOX1, ZNF547, MYOD1, AR, ZNF324, HEXIM1, ZNF280D, AHR, DMAP1, FOSL2, ZNF391, HMG20A, HMGN3, SUZ12, RBFOX2, ZNF28, ZFHX2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, MECOM, ZNF736, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, USF2, ZFP91, TCF12, BAF155, EP300, PRDM4, SOX6, CREB3, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, BRD1, MYCN, RUNX1T1, ID3, GATAD1, GMEB2, ARID3A, RAD21, GRHL3, APC, XRCC5, ZNF614, ZNF639, ARNTL, FEZF1, TFE3, EHF, HBP1, IRF1, ZGPAT, NAB2, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, FIP1L1, ZNF534, ZFX, ZNF335, SMAD3, PCBP2, NMYC, PRPF4, BRD9, ZSCAN30, GATA4, OSR2, ZNF184, PBX4, NRF1, SUPT5H, FOS, CHD1, MED1, CEBPD, SCRT2, VEZF1, ZNF3, L3MBTL2, SETDB1, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, SKI, NELFA, FOXA2, RBBP5, E2F8, MIER2, ZBED1, ZBTB33, HOXB13, YY1, SP140, HIF1A, OTX2, ZNF449, GATA1, TLE3, CEBPG, SP7, NR2F2, ZNF687, ZNF213, NFKBIZ, BHLHE40, TAF1, ZBTB40, NOTCH3, CLOCK, MAZ, BRCA1

Target gene symbol (double-evidenced CRMs): USP25,BTG3,CXADR,C21orf91

Function elements

Human SNPs: .

Number of somatic mutations (coding): 14

Number of somatic mutations (non-coding): 5

Related genes and loops

Related gene: ENSG00000155313, ENSG00000154639, ENSG00000154640, ENSG00000154642,

eachgene

Deatailed information for cohesin site CDBP00414005