Deatailed information for cohesin site CDBP00414054

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  • Basic information
  • CohesinDB ID: CDBP00414054
  • Locus: chr21-17817153-17820909
  • Data sourse: ENCSR000BLD, GSE206145-GSE177045, GSE104888, ENCSR230ZWH, GSE72082, GSE126634, GSE116868, ENCSR000BLY, ENCSR404BPV, ENCSR150EFU, GSE105028, GSE121355, GSE103477, GSE111537, GSE131606, GSE108869, GSE25021, ENCSR917QNE, ENCSR000EFJ, ENCSR000BTU, GSE165895, ENCSR000DZP, ENCSR000EAC, GSE143937, ENCSR000BKV, GSE67783, GSE138405, GSE86191, GSE93080, GSE76893, GSE101921, GSE51234, GSE206145-NatGen2015, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, GSE116344, GSE106870, GSE138105, GSE118494, ENCSR338DUC, GSE98367, GSE206145, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, GSE85526, ENCSR000ECE, ENCSR981FDC, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, ENCSR748MVX, ENCSR767DFK, GSE62063, ENCSR217ELF, ENCSR000BTQ, GSE38395, ENCSR167MTG, GSE55407, GSE131956, GSE110061, GSE129526, ENCSR000HPG, GSE111913, GSE155324, ENCSR054FKH, ENCSR537EFT, ENCSR153HNT, GSE68388, GSE83726, GSE126990, GSE50893, GSE126755, ENCSR000ECS, GSE64758, GSE38411
  • Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, GP5d, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, Macrophage, MCF-7, GM12892, Ramos, Hela-Kyoto, HCT-116, MCF-10A, HEK293T, Hep-G2, Neurons-H1, A-549, HCAEC, GM19238, Neutrophil, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 44% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.278
  • Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 47% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): non-Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "2_TssAFlnk": 27%, "1_TssA": 25%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, RXRB, MLL4, KDM3A, MEN1, THAP1, IKZF3, MORC2, PAX5, SFPQ, TEAD1, ZNF121, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, E4F1, ARID5B, SOX5, E2F4, DEK, ZNF674, RFX3, KMT2B, GATAD2A, JARID2, NANOG, BRD3, ZNF263, TOP2A, POU5F1, CTBP1, DUX4, STAT1, SAP130, ERG, NFKB2, EZH1, SMARCA4, RFX1, TOP1, FOXK2, RCOR1, NUFIP1, NR2F6, NFRKB, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, GATA2, ZNF644, MXD3, SIX2, FLI1, HCFC1, MXI1, DRAP1, RELB, EP400, RUNX1, CEBPA, HDAC1, NKX2-2, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, ELK1, TFDP1, ATF2, FOXM1, SP2, SMARCB1, GMEB1, PML, PIAS1, SMAD1, NR1H2, MBD1, GSPT2, IKZF5, ARID2, RBM25, AFF1, MBD2, ELL2, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, SS18, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, ZFP36, TCF4, BATF, MAF1, SPIB, PLAG1, KLF4, BCL11B, ZBTB6, MED, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, ILF3, ZNF316, ZNF660, XBP1, KDM4B, ZNF101, SRSF4, PBX2, HNRNPK, ATF3, ZFP64, HNRNPUL1, RUNX3, ZNF532, CBFB, TP63, MITF, JMJD1C, INTS11, MAF, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, JUN, TAF3, CTCF, MNT, LMO1, DPF2, RYBP, SIX5, IRF4, ZNF350, PDX1, TFAP2C, RBPJ, MLX, MTA2, ZBTB17, ZBTB48, NONO, SRF, DDX5, NBN, ONECUT1, KDM4A, HOMEZ, FOXP2, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, LEF1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, TBL1XR1, KLF8, GRHL2, EBF3, ZBTB14, SMARCA5, NFIL3, THAP11, CTNNB1, ZBTB24, EZH2phosphoT487, SOX13, AFF4, POU4F2, ZMIZ1, SP3, ARNT, BACH1, ZNF48, PRDM9, HMBOX1, NFYA, ZEB2, PBX3, NCAPH2, MAFB, ZNF10, HMGXB4, TEAD3, DIDO1, ZXDB, U2AF1, TAF7, KLF9, USF1, SP1, BCL11A, TFAP2A, ATF7, ASH2L, CTBP2, PCGF2, GLIS2, SMC3, MLLT1, STAG2, STAG1, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ZNF580, ZKSCAN1, BCL3, KDM1A, BRG1, ZIC2, PCGF1, GATA3, TAL1, ZNF143, AGO2, MTA1, ZNF141, TP53, ZSCAN22, NFKB1, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, JUND, SPIN1, BRD4, CUX1, ZSCAN23, TBX2, PGR, SOX2, PATZ1, RING1B, UBTF, LEO1, SIN3B, BMI1, CHD7, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, KLF1, SOX9, SOX4, E2F6, TRIM24, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ASH1L, ZSCAN5A, ELK4, HIC1, SP4, ERG2, TBP, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, DNMT3B, INO80, SRSF3, EZH2, ZNF652, MRTFA, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, TAF9B, ZNF777, ZNF76, ETV5, BCL6, SIN3A, ZBTB12, ZFP37, ERG3, MEF2A, CREBBP, ZNF384, RARA, NFYC, TAF15, ZNF35, SMAD4, CDK8, CSNK2A1, ZEB1, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, ZNF34, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, TCF7, FOXO3, RELA, TARDBP, SKIL, MGA, MAX, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, T, AR, KMT2D, PAX3-FOXO1, ZNF324, HEXIM1, DMAP1, AHR, FOSL2, ZNF391, HMG20A, HMGN3, SUZ12, RBFOX2, ZFHX2, SFMBT1, NFIC, ZNF362, CTCFL, ZBTB5, PRDM1, KLF14, MECOM, CDX2, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, USF2, ZFP91, TCF12, EP300, BAF155, GATA6, PRDM4, ZNF512B, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, GATAD1, ARID3A, ASCL1, ZNF341, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, NFE2, ZNF639, ZNF501, ZNF750, TFE3, EHF, HBP1, IRF1, SREBF1, ZGPAT, NAB2, MRTFB, ATF1, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, PCBP2, TWIST1, IRF2, NCOA6, PRPF4, NOTCH1, RUNX2, ZSCAN30, GATA4, CDK6, ZNF184, OSR2, PBX4, NRF1, SUPT5H, FOS, CHD1, MED1, CEBPD, MYB, KDM6B, VEZF1, ZNF3, L3MBTL2, NIPBL, ZBTB7A, CCNT2, PHIP, TCF3, ZNF783, SKI, NELFA, FOXA2, RBBP5, E2F8, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, BRCA1, SP140, HIF1A, OTX2, ZNF519, GATA1, CEBPG, SP7, NR2F2, ZNF213, BHLHE40, NFKBIZ, TAF1, ZNF579, ZBTB40, MYNN, NOTCH3, CLOCK, MAZ, ZNF24
  • Target gene symbol (double-evidenced CRMs): BTG3,C21orf91,CXADR
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 54
  • Number of somatic mutations (non-coding): 12
  • Related genes and loops
  • Related gene: ENSG00000154639, ENSG00000154640, ENSG00000154642,
  • Related loop: chr21:16575000-16600000~~chr21:17800000-17825000, chr21:17375000-17400000~~chr21:17825000-17850000, chr21:17450000-17475000~~chr21:17825000-17850000, chr21:17575000-17600000~~chr21:17800000-17825000, chr21:17600000-17625000~~chr21:17800000-17825000, chr21:17675000-17700000~~chr21:17800000-17825000, chr21:17678482-17679945~~chr21:17817779-17820820, chr21:17688092-17690151~~chr21:17817660-17820812, chr21:17800000-17825000~~chr21:17900000-17925000, chr21:17817784-17820842~~chr21:17901964-17904398, chr21:17818177-17820852~~chr21:17902238-17904394, chr21:17825000-17850000~~chr21:18000000-18025000, chr21:17825000-17850000~~chr21:18225000-18250000,
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