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Basic information

CohesinDB ID: CDBP00415483

Locus: chr21-26388039-26392190

Data sourse: GSE206145-GSE177045, GSE104888, ENCSR501LQA, ENCSR150EFU, ENCSR000ECS, GSE131606, GSE25021, GSE165895, GSE138405, GSE101921, GSE206145-NatGen2015, GSE116344, ENCSR193NSH, GSE206145, GSE85526, ENCSR247LSH, ENCSR000EHX, ENCSR620NWG, ENCSR853VWZ, ENCSR956LGB, GSE111913, ENCSR000EDE, GSE68388, GSE83726, GSE126990, ENCSR748MVX

Cell type: MCF-7, RPE, HMEC, Fibroblast, HCT-116, Hela-Kyoto, HEKn, RH4, A-549, HCAEC, HeLa-S3, SK-N-SH, RT-112, HFFc6, HuCC-T1, DKO

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 15% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.822

Subunit: NIPBL,SA1,Rad21,SMC1,SA2,Mau2,SMC3

CTCF binding site: CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: non-Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: False ChIA-PET loops: True

Compartment: 54% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): non-Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "15_Quies": 56%, "7_Enh": 25%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, FOSL1, PGR, SMARCA2, E2F7, SOX2, FOXA1, TFAP4, ATF3, CHD7, PRDM1, PAX5, TP63, MITF, MYOG, MAF, KLF5, ELF1, TEAD1, TRIM28, KLF6, SNAI2, ETV1, NFE2L2, LMO2, ESR1, HNF1B, TP73, USF2, JUN, TCF12, CTCF, EP300, DPF2, SOX4, TRIM24, IRF4, E2F1, SMC1, TEAD4, KMT2B, PDX1, TFAP2C, GLIS1, POU2F2, CHD8, POU5F1, MYCN, CDK7, RUNX1T1, TOP2A, DUX4, SRF, TBP, ERG, HOXC5, PBX1, NFKB2, ETS1, MYC, SMARCA4, RAD21, RXRA, NKX2-1, STAT3, SOX10, NKX3-1, RCOR1, ARNTL, NR3C1, ZNF750, CEBPB, ESRRA, KMT2A, CREB1, EZH2, GRHL2, EBF3, TRPS1, ZHX2, SPI1, EHF, IRF1, GATA2, FLI1, MRTFB, NCOA2, MYF5, RUNX1, SMC1A, BCL6, CEBPA, NKX2-2, EZH2phosphoT487, SIN3A, SMAD3, SMARCC1, TWIST1, CREBBP, NOTCH1, RUNX2, CDK6, GATA4, GR, PBX4, DAXX, ARNT, NRF1, MAFB, FOS, CDK8, MED1, ZEB1, SPDEF, CEBPD, MYB, SETDB1, TBX5, USF1, NIPBL, SP1, TFAP2A, BCL11A, NKX2-5, REST, ARID1A, PHIP, TCF3, FOXP1, STAG2, STAG1, SKI, PPARG, FOXA2, CBX3, CHD2, MEIS1, ESR2, MEF2C, CDK9, KDM1A, YY1, RELA, JUNB, NEUROD1, ISL1, TCF4, HIF1A, OTX2, GATA3, BHLHE22, TAL1, MAX, NRIP1, SPIB, ZNF143, HAND2, KLF4, NCOA3, NR2F2, TCF7L2, NEUROG2, KDM5B, TP53, PKNOX1, MED, NFKB1, MYOD1, ELF3, BRD2, AR, YAP1, EGLN2, HSF1, NCOR1, NOTCH3, JUND, BRD4, TBX2, AHR, FOSL2

Target gene symbol (double-evidenced CRMs): APP,MRPL39,GABPA,CYYR1

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 44

Related genes and loops

Related gene: ENSG00000154719, ENSG00000154727, ENSG00000142192, ENSG00000166265,

eachgene

Deatailed information for cohesin site CDBP00415483