Deatailed information for cohesin site CDBP00416183

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  • Basic information
  • CohesinDB ID: CDBP00416183
  • Locus: chr21-29296491-29303668
  • Data sourse: ENCSR230ZWH, ENCSR000FAD, ENCSR000BSB, ENCSR000EGW, GSE131606, ENCSR330ELC, ENCSR000BUC, ENCSR917QNE, GSE115602, GSE93080, GSE67783, GSE86191, GSE101921, ENCSR806UKK, GSE120943, ENCSR198ZYJ, GSE112028, GSE130135, ENCSR199XBQ, GSE94872, ENCSR895JMI, GSE118494, ENCSR000EEG, ENCSR338DUC, GSE168045, ENCSR247LSH, ENCSR676MJK, GSE155324, ENCSR054FKH, GSE83726, GSE126755, ENCSR748MVX, ENCSR000ECS, GSE131577, ENCSR000BLD, GSE38411, GSE104888, GSE126634, GSE103477, GSE108869, GSE143937, GSE138405, GSE135093, GSE106870, ENCSR193NSH, GSE206145, GSE85526, ENCSR000ECE, ENCSR620NWG, ENCSR767DFK, ENCSR984DZW, GSE55407, ENCSR000BTQ, GSE129526, ENCSR537EFT, ENCSR760NPX, ENCSR000BLY, ENCSR150EFU, GSE121355, GSE111537, GSE25021, ENCSR000EAC, GSE115250, GSE76893, GSE145327, GSE76815, ENCSR000BMY, ENCSR000EHX, ENCSR635OSG, GSE97394, ENCSR217ELF, GSE38395, GSE131956, GSE110061, ENCSR000HPG, GSE111913, ENCSR335RKQ, ENCSR000EDE, GSE50893, ENCSR481YWD, GSE206145-GSE177045, GSE72082, ENCSR501LQA, GSE116868, ENCSR404BPV, GSE105028, ENCSR000EDW, GSE165895, ENCSR000EFJ, ENCSR000BTU, ENCSR000DZP, ENCSR000BKV, GSE206145-NatGen2015, GSE138105, ENCSR703TNG, GSE116344, GSE98367, ENCSR768DOX, ENCSR879KXD, ENCSR000BLS, ENCSR000EHW, ENCSR981FDC, ENCSR807WAC, GSE62063, ENCSR495WGO, ENCSR167MTG, ENCSR853VWZ, ENCSR956LGB, ENCSR944ZCT, ENCSR153HNT, GSE68388, GSE126990
  • Cell type: MDM, RH4, GM10847, GM2610, SLK, CVB-hiPSC, GM19240, OCI-AML-3, HSPC, CVI-hiPSC, Liver, TC-32, HuCC-T1, B-cell, H9-hESC, GM2630, RPE, Fibroblast, HEKn, THP-1, Ishikawa, GM12890, HeLa-S3, hLCL, GM2255, IMR-90, BCBL-1, K-562, GM18486, DKO, HFFc6, GM18526, H1-hESC, SNYDER, Monocytes, GM18505, MB157, Lymphoblast, GM12878, GM12891, GM2588, GBM39, HUES9, SK-N-SH, GM19239, HeLa-Tet-On, GM19193, RT-112, HAP1, GM19099, HUES64, Macrophage, GM12892, MCF-7, Hela-Kyoto, HCT-116, HL-60, HEK293T, Hep-G2, MCF-10A, Neurons-H1, SC, A-549, HUVEC, HCAEC, Ramos, GM19238, Neutrophil, GM18951
  • DNA Sequence of binding site: UCSC hg38
  • Cohesin category
  • Peak occupancy ratio: 76% samples have this site.
  • Cell specificity (0: conserved, 1: cell type specific): 0.211
  • Subunit: NIPBL,SA1,Rad21,SMC1,SMC3ac,SA2,Mau2,SMC3
  • CTCF binding site: CTCF CTCF motif: False
  • Genomic location: TSS
  • 3D genome
  • TAD boundary: non-Boundary
  • Chromatin hubs: Hub
  • Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True
  • Compartment: 68% Hi-C samples shows Compartment A
  • Cis-regulatory elements
  • Enhancer (Fantom5): Enhancer
  • Super enhancer (SEdb): True
  • Chromatin annotation: "2_TssAFlnk": 26%, "7_Enh": 24%,
    Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
  • Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, THAP1, ZBTB44, IKZF3, MORC2, PAX5, TEAD1, SNAPC1, LMO2, OCA2, MED26, PITX3, HDAC8, ZNF561, ZNF577, E4F1, SOX5, PAX8, E2F4, DEK, ZNF410, ZNF528, RFX3, KLF3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, POU5F1, BRD3, CTBP1, ERF, STAT1, ZNF134, SAP130, ERG, ZBTB21, ZBTB8A, EZH1, SMARCA4, RFX1, FOXK2, UBN1, ZNF398, RCOR1, NR2F6, CD74, NFRKB, DACH1, CEBPB, HNRNPL, CREB1, BMPR1A, GABPB1, ZHX2, ELF4, MIXL1, ZNF257, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, NR2C2, MXI1, HCFC1, ZNF785, RELB, EP400, RUNX1, HDAC1, CEBPA, NKX2-2, REPIN1, TBX3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, TFDP1, ZBTB10, ATF2, SATB1, FOXM1, SP2, SMARCB1, GMEB1, PML, TERF1, PIAS1, SMAD1, NR1H2, C11orf30, EVI1, MBD1, STAT5A, GSPT2, IKZF5, ARID2, RBM25, AFF1, MBD2, ZNF337, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, CBX3, ZNF207, CREM, CHD2, SS18, PAF1, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, NEUROD1, JUNB, TCF4, ZFP36, BATF, MAF1, PLAG1, ZFP69B, BCL11B, KLF4, ZNF530, ZBTB6, MED, EGR2, ELF3, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, HSF1, NCOR1, SCRT1, ILF3, ZNF316, FOSL1, ZNF660, XBP1, HNF1A, KDM4B, ZNF101, PBX2, HNRNPK, TSC22D4, ATF3, THRB, ZFP64, RUNX3, CBFB, DPF1, TP63, ZSCAN4, MITF, BACH2, INTS11, MAF, JMJD1C, ELF1, RBM39, SNAI2, KLF10, SMAD5, FUS, CTCF, JUN, TAF3, ZBTB20, MNT, LMO1, RYBP, DPF2, IRF4, ZNF423, ZNF280A, PDX1, MLX, RBPJ, TFAP2C, ZNF317, MTA2, ZBTB48, ZBTB17, ZSCAN21, NONO, SRF, NBN, CHD4, PBX1, KDM4A, HOMEZ, FOXP2, ZNF2, TSHZ1, RXRA, BATF3, NKX3-1, MIER3, LEF1, TERF2, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, ZBTB14, SSRP1, ZNF146, ZSCAN29, SMARCA5, NFIL3, THAP11, LDB1, SOX13, AFF4, ZNF770, ZMIZ1, SP3, ARNT, BACH1, DAXX, ZNF48, PRDM9, ZEB2, HMBOX1, NFYA, ETV6, NCAPH2, MAFB, PBX3, HMGXB4, ZNF10, TEAD3, ZXDB, ZNF680, U2AF1, TAF7, KLF9, ZBTB18, USF1, SP1, BCL11A, TFAP2A, NKX2-5, ATF7, ASH2L, GLIS2, PRDM6, ZNF623, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, SAFB, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, ZKSCAN1, BCL3, KDM1A, ZNF19, ZNF441, BRG1, ZIC2, PCGF1, GATA3, TAL1, NRIP1, ZNF143, AGO2, MTA1, TP53, ZNF334, NFKB1, ZSCAN22, ZNF140, PHOX2B, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, IKZF2, BRD4, JUND, SPIN1, ZSCAN23, TBX2, ZNF468, PGR, SOX2, PATZ1, RING1B, UBTF, LEO1, TFAP4, SIN3B, CHD7, ATF4, MXD4, ZNF189, SMARCE1, KLF6, NFE2L2, SAP30, ESR1, TP73, SND1, KLF1, ZNF695, SOX4, E2F6, TRIM24, RFX5, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ZMYND8, ERG2, SP4, HIC1, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, ARID1B, KLF12, NKX2-1, MCRS1, GABPA, STAT3, IKZF1, ZNF343, INO80, DNMT3B, SRSF3, EZH2, ZNF652, NFE2L1, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, TAF9B, ZNF76, ZNF554, NFYB, ETV5, BCL6, SIN3A, ZNF132, ZFP37, ERG3, MEF2A, RARA, ZNF384, CREBBP, NFYC, TAF15, ZNF35, HMGB2, SMAD4, ZNF518A, CBFA2T3, CDK8, CSNK2A1, ZEB1, ZMYM3, SUPT16H, NCOA1, GTF3C2, SREBF2, RBM22, MAFK, HNF4A, NR4A1, REST, ARID1A, ZHX1, HNRNPLL, BCOR, FOXP1, AATF, NCOR2, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF30, ZNF574, TCF7, ZNF318, RELA, TARDBP, SKIL, MGA, MAX, ZNF592, GFI1B, NR2F1, TCF7L2, KDM5B, NEUROG2, PKNOX1, MYOD1, AR, KMT2D, ZNF324, HEXIM1, AHR, DMAP1, FOSL2, ZNF391, HMG20A, ZSCAN5C, E2F7, HMGN3, MEIS2, SUZ12, RBFOX2, ZFHX2, INSM2, NFIC, ZNF362, CTCFL, PRDM1, KLF14, MECOM, ZNF736, CDX2, ZNF629, KLF5, BCLAF1, TRIM28, ETV1, RCOR2, HNF1B, MLL, USF2, TCF12, EP300, BAF155, GATA6, PRDM4, SOX6, CREB3, RAD51, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EHMT2, EED, CHD8, BRD1, MYCN, CDK7, RUNX1T1, ID3, GATAD1, GMEB2, ARID3A, ASCL1, MIER1, ZNF341, RAD21, GRHL3, PROX1, XRCC5, ZNF614, NFE2, ZNF639, ARNTL, ZNF750, JMJD6, FEZF1, TRPS1, TFE3, HBP1, EHF, IRF1, SREBF1, ZGPAT, NAB2, MRTFB, MYF5, ATF1, PTBP1, SMC1A, CBX1, MAFG, SIRT6, ZNF335, ZFX, FIP1L1, SMAD3, NMYC, TWIST1, IRF2, PRPF4, NOTCH1, BRD9, RUNX2, CDK6, ZSCAN30, GATA4, ZNF184, SMAD2, OSR2, NRF1, PBX4, GR, SUPT5H, FOS, CHD1, TGIF2, MED1, KDM6B, MYB, SCRT2, CEBPD, ZNF558, VEZF1, ZNF3, L3MBTL2, SETDB1, KLF16, NIPBL, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, ZNF783, SKI, NELFA, KLF13, FOXA2, RBBP5, E2F8, ZNF600, MIER2, ZBED1, FOXF1, ZBTB33, CDK9, HOXB13, YY1, ZNF148, ASXL1, ZNF610, SP140, BRCA1, HIF1A, OTX2, ZNF519, ZNF449, GATA1, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, ZNF843, NFKBIZ, BHLHE40, TAF1, ZBTB40, ZBTB42, MYNN, NOTCH3, MAZ, ZNF440, ZNF24
  • Target gene symbol (double-evidenced CRMs): BACH1,MAP3K7CL,TIAM1,USP16,GRIK1,CCT8
  • Function elements
  • Human SNPs: .
  • Number of somatic mutations (coding): 62
  • Number of somatic mutations (non-coding): 34
  • Related genes and loops
  • Related gene: ENSG00000156256, ENSG00000156261, ENSG00000156265, ENSG00000156273, ENSG00000171189, ENSG00000156299,
  • Related loop: chr21:29050000-29075000~~chr21:29300000-29325000, chr21:29075000-29100000~~chr21:29275000-29300000, chr21:29089226-29091194~~chr21:29297826-29300567, chr21:29089325-29091118~~chr21:29297646-29300784, chr21:29100000-29125000~~chr21:29275000-29300000, chr21:29150000-29175000~~chr21:29275000-29300000, chr21:29162298-29165502~~chr21:29297765-29300738, chr21:29162305-29165453~~chr21:29297767-29300990, chr21:29162307-29165517~~chr21:29297019-29300536, chr21:29162310-29165464~~chr21:29297711-29300996, chr21:29162377-29165492~~chr21:29297770-29301094, chr21:29162378-29165498~~chr21:29297718-29300698, chr21:29162871-29165217~~chr21:29297676-29300550, chr21:29163305-29165274~~chr21:29297780-29300635, chr21:29163333-29165304~~chr21:29297741-29300792, chr21:29163629-29165264~~chr21:29297785-29301017, chr21:29175000-29200000~~chr21:29275000-29300000, chr21:29175000-29200000~~chr21:29300000-29325000, chr21:29181177-29183351~~chr21:29297767-29300990, chr21:29195502-29197292~~chr21:29297767-29300990, chr21:29230443-29234332~~chr21:29297765-29300738, chr21:29232806-29234518~~chr21:29297832-29300927, chr21:29235070-29236701~~chr21:29297903-29299607, chr21:29275000-29300000~~chr21:29675000-29700000, chr21:29275000-29300000~~chr21:29800000-29825000, chr21:29275000-29300000~~chr21:31150000-31175000, chr21:29300000-29325000~~chr21:33200000-33225000,
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