- Basic information
- CohesinDB ID: CDBP00416195
- Locus: chr21-29322647-29323646
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Data sourse: GSE72082, ENCSR230ZWH, GSE98367, ENCSR000BLS, ShirahigeLab, GSE120943, ENCSR917QNE
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Cell type: RPE, Monocytes, Hep-G2, Liver, Macrophage
- DNA Sequence of binding site:
UCSC hg38
- Cohesin category
- Peak occupancy ratio: 1% samples have this site.
- Cell specificity (0: conserved, 1: cell type specific): 0.944
- Subunit: NIPBL,Rad21,SMC1
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CTCF binding site: non-CTCF
CTCF motif: False
- Genomic location: Intragenic
- 3D genome
- TAD boundary: non-Boundary
- Chromatin hubs: Hub
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Hi-C loops: True
Hi-ChIP loops: False
ChIA-PET loops: True
- Compartment:
68% Hi-C samples shows Compartment A
- Cis-regulatory elements
- Enhancer (Fantom5): non-Enhancer
- Super enhancer (SEdb): True
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Chromatin annotation:
"4_Tx": 51%,
"5_TxWk": 35%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).
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Co-bound Transcriptional factors: RUNX1, NFYB, PGR, CHD8, CBX1, FOXA2, CBX3, TBL1X, POU2F2, CEBPA, ZFX, ZNF600, XBP1, POU4F2, ZBTB48, ZSCAN5A, WT1, ZBTB33, CDK9, ZNF28, PRDM10, YY1, RELA, TARDBP, JUNB, ATF3, MYC, NFIC, GATA4, EOMES, CHAMP1, RAD21, PRDM1, GRHL3, HIF1A, ATF4, OTX2, ATF2, TAL1, RXRA, STAT3, FOXM1, TP63, PAX5, ZNF143, CDK8, SUPT5H, GATA1, ZNF639, IRF9, CEBPG, CEBPB, MYOG, NCOA3, TRIM28, EZH2, KDM5B, SUPT16H, SETDB1, CTCF, RBM22, SP1, MNT, AR, ZNF202, HNF4A, REST, TRIM24, ZHX1, FLI1, NOTCH3, JUND, BRD4, BCOR, ZNF528, NCOA2, ZNF24, CC2D1A
- Target gene symbol (double-evidenced CRMs): CCT8,BACH1,USP16,MAP3K7CL
- Function elements
- Human SNPs: .
- Number of somatic mutations (coding): 14
- Number of somatic mutations (non-coding): 7
- Related genes and loops
- Related gene:
ENSG00000156256,
ENSG00000156261,
ENSG00000156265,
ENSG00000156273,
- Related loop:
chr21:29050000-29075000~~chr21:29300000-29325000,
chr21:29075000-29100000~~chr21:29325000-29350000,
chr21:29150000-29175000~~chr21:29325000-29350000,
chr21:29175000-29200000~~chr21:29300000-29325000,
chr21:29225000-29250000~~chr21:29325000-29350000,
chr21:29300000-29325000~~chr21:33200000-33225000,