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Basic information

CohesinDB ID: CDBP00415432

Locus: chr21-26165409-26165563

Data sourse: ENCSR000BLY, GSE68388

Cell type: HuCC-T1, SK-N-SH

DNA Sequence of binding site: UCSC hg38

Cohesin category

Peak occupancy ratio: 0% samples have this site.

Cell specificity (0: conserved, 1: cell type specific): 0.978

Subunit: Rad21,SMC1

CTCF binding site: non-CTCF CTCF motif: False

Genomic location: Intragenic

3D genome

TAD boundary: Boundary

Chromatin hubs: Hub

Hi-C loops: True Hi-ChIP loops: True ChIA-PET loops: True

Compartment: 68% Hi-C samples shows Compartment A

Cis-regulatory elements

Enhancer (Fantom5): Enhancer

Super enhancer (SEdb): True

Chromatin annotation: "5_TxWk": 36%, "7_Enh": 36%,
Note: The percentage represent how many of the 127 Roadmap datasets show the indicated state (top 2).

Co-bound Transcriptional factors: FOXO1, NFIA, TRIM25, NME2, FOXA1, HLF, RXRB, MLL4, KDM3A, HDGF, MEN1, THAP1, ZBTB44, IKZF3, MORC2, PAX5, SFPQ, TEAD1, ZNF121, OCA2, MED26, PITX3, ZNF561, ARID5B, SOX5, DEK, E2F4, ZNF528, KLF3, KMT2B, GATAD2A, JARID2, NANOG, ZNF263, BRD3, TOP2A, POU5F1, CTBP1, ERF, DUX4, STAT1, SAP130, ERG, ZBTB8A, EZH1, SMARCA4, RFX1, TOP1, UBN1, ZNF398, RCOR1, NR2F6, CEBPB, HNRNPL, CREB1, GABPB1, ZHX2, MIXL1, KLF17, GATA2, ZNF644, MXD3, FLI1, DRAP1, MXI1, HCFC1, RELB, RUNX1, CEBPA, NKX2-2, IRF3, SP5, TRIM22, SMARCC1, PRDM10, ZBTB2, CBX4, TFDP1, ZBTB10, ATF2, FOXM1, SP2, SMARCB1, PML, PIAS1, SMAD1, MBD1, GSPT2, IKZF5, ARID2, RBM25, ELL2, HMGB1, ETV4, NFATC3, CBFA2T2, MEF2B, ZNF207, CBX3, CREM, CHD2, PAF1, SS18, NFATC1, ZSCAN16, WT1, MEF2C, CREB3L1, JUNB, NEUROD1, TCF4, ZFP36, BATF, PLAG1, KLF4, BCL11B, ZFP69B, ZNF530, ZBTB6, MED, BCL6B, EGR2, ELF3, RBM14, ARID4B, RXR, EGLN2, ZNF366, ZBTB26, NCOR1, HSF1, SCRT1, FOSL1, ZNF660, HNF1A, XBP1, KDM4B, ZNF596, HNRNPK, ATF3, ZFP64, HNRNPUL1, RUNX3, CBFB, ZNF273, ZSCAN4, TP63, MITF, ZNF467, JMJD1C, INTS11, MAF, ELF1, RBM39, SNAI2, KLF10, FUS, CTCF, JUN, TAF3, ZBTB20, MNT, LMO1, RYBP, DPF2, IRF4, ZNF423, PDX1, RBPJ, TFAP2C, MLX, ZNF239, ZSCAN21, ZBTB17, ZBTB48, MTA2, ZNF317, NONO, SRF, NBN, ONECUT1, ZNF2, HOMEZ, KDM4A, FOXP2, TSHZ1, RXRA, NKX3-1, PRDM14, MIER3, HNRNPH1, VDR, NR3C1, ESRRA, STAT5B, KMT2A, ZBTB11, CCAR2, TBL1XR1, KLF8, GRHL2, EBF3, ZKSCAN5, ZBTB14, ZSCAN29, SMARCA5, NFIL3, THAP11, ZNF585A, LDB1, SOX13, AFF4, ZNF770, ZNF513, SP3, DAXX, ARNT, NFIB, BACH1, ZNF48, PRDM9, ZEB2, PBX3, NCAPH2, ZNF10, MAFB, HMGXB4, TEAD3, ZXDB, U2AF1, TAF7, KLF9, TBX5, USF1, SP1, BCL11A, ATF7, ASH2L, CTBP2, GLIS2, PRDM6, SMC3, MLLT1, STAG1, STAG2, ZNF394, TRP47, AGO1, MTA3, EBF1, MAFF, ESR2, ZNF580, BCL3, KDM1A, BRG1, ISL1, ZIC2, PCGF1, GATA3, TAL1, ZNF143, AGO2, MTA1, TP53, ZNF334, ZSCAN22, NFKB1, ZNF140, BRD2, PHF5A, KAT8, ARRB1, TBX21, EGR1, RB1, TFIIIC, RNF2, JUND, BRD4, SPIN1, CUX1, ZSCAN23, ZFP42, ZNF468, PGR, FANCL, SOX2, PATZ1, LEO1, RING1B, TFAP4, SIN3B, BMI1, CHD7, ZNF444, MXD4, ZNF189, SMARCE1, MZF1, KLF6, NFE2L2, SAP30, ESR1, ZNF217, TP73, ZNF524, KLF1, ZNF695, SOX9, SOX4, E2F6, TRIM24, RFX5, ZNF92, GTF2F1, GLIS1, POU2F2, ZSCAN5D, KDM4C, ZSCAN5A, ERG2, SP4, HIC1, TBP, HNF4G, HOXC5, OGG1, SMARCC2, ETS1, MYC, NKX2-1, GABPA, MCRS1, STAT3, IKZF1, INO80, DNMT3B, EZH2, ZNF652, PHF8, SPI1, ZNF202, PCBP1, HDAC2, INTS13, GATAD2B, ZNF777, ZNF76, ZNF554, ETV5, BCL6, SIN3A, ZFP37, ERG3, NFXL1, RARA, ZNF384, ZNF35, CREBBP, TAF15, NFYC, SMAD4, CDK8, CSNK2A1, ZEB1, SPDEF, SREBF2, RBM22, HNF4A, NR4A1, REST, ARID1A, ZHX1, HOXA9, HNRNPLL, BCOR, FOXP1, AATF, CXXC4, PPARG, TBL1X, HDAC6, ZNF692, GTF2B, ZNF574, FOXO3, RELA, TARDBP, MGA, MAX, ZNF592, GFI1B, NEUROG2, TCF7L2, KDM5B, NR2F1, ZNF791, PKNOX1, MYOD1, AR, KMT2D, ZNF324, HEXIM1, AHR, FOSL2, DMAP1, MBD3, ZNF391, HMG20A, ZSCAN5C, HMGN3, SUZ12, RBFOX2, ZFHX2, SFMBT1, NFIC, ZNF362, CTCFL, PRDM1, KLF14, MECOM, HDAC3, CDX2, ZNF629, KLF5, TRIM28, BCLAF1, ETV1, RCOR2, HNF1B, USF2, TCF12, BAF155, EP300, GATA6, PRDM4, E2F1, SMC1, TEAD4, FOXA3, ZNF175, EED, CHD8, BRD1, MYCN, RUNX1T1, CDK7, GATAD1, ARID3A, ZNF341, RAD21, GRHL3, PROX1, APC, ZNF614, XRCC5, NFE2, ZNF639, ZNF750, ZNF501, JMJD6, FEZF1, TRPS1, TFE3, EHF, ZNF664, IRF1, HBP1, SREBF1, ZGPAT, ZNF766, MRTFB, PTBP1, SMC1A, CBX1, SIRT6, ZNF335, ZFX, ZNF534, FIP1L1, SMAD3, NMYC, CBX8, TWIST1, NOTCH1, RUNX2, CDK6, GATA4, OSR2, GR, ZSCAN30, ZNF184, PBX4, NRF1, FOS, CHD1, TGIF2, MED1, KDM6B, MYB, SCRT2, CEBPD, VEZF1, L3MBTL2, SETDB1, NIPBL, ZBTB7A, CCNT2, POU2F3, PHIP, TCF3, SKI, PAX7, NELFA, ZNF283, FOXA2, RBBP5, ZNF600, MIER2, FOXF1, CDK9, HOXB13, YY1, ASXL1, BRCA1, SP140, ZNF610, HIF1A, OTX2, BHLHE22, ZNF449, GATA1, HAND2, TLE3, CEBPG, SP7, NCOA3, NR2F2, ZNF687, ZNF213, ZNF843, BHLHE40, NFKBIZ, TAF1, ZNF846, NOTCH3, CLOCK, MAZ, ZNF24

Target gene symbol (double-evidenced CRMs): MRPL39,GABPA,APP,ADAMTS1,CYYR1,JAM2

Function elements

Human SNPs: .

Number of somatic mutations (coding): 0

Number of somatic mutations (non-coding): 0

Related genes and loops

Related gene: ENSG00000154719, ENSG00000154721, ENSG00000154727, ENSG00000142192, ENSG00000166265, ENSG00000154734,

eachgene

Deatailed information for cohesin site CDBP00415432