Deatailed information for gene ENSG00000157538
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00010105
- Gene Symbol: VPS26C
- Ensembl ID: ENSG00000157538
-
Gene locus: chr21:37223421-37267334
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-36953935-36954529,
chr21-36956521-36956982,
chr21-36957810-36958241,
chr21-36958523-36960338,
chr21-36962318-36962811,
chr21-36964520-36968171,
chr21-36969535-36969868,
chr21-36973649-36974411,
chr21-36974936-36975856,
chr21-36976322-36979183,
chr21-36980355-36981128,
chr21-36982411-36982979,
chr21-36983475-36983812,
chr21-36985242-36985787,
chr21-36986346-36986700,
chr21-36987033-36987211,
chr21-36987845-36988197,
chr21-36988629-36988824,
chr21-36989082-36991140,
chr21-36992148-36992448,
chr21-36992692-36993739,
chr21-36994195-36995191,
chr21-36996016-36996897,
chr21-36997444-36998032,
chr21-36999928-37001231,
chr21-37052914-37053240,
chr21-37055442-37055918,
chr21-37057230-37057964,
chr21-37058503-37058789,
chr21-37059694-37061303,
chr21-37061566-37062938,
chr21-37063355-37065228,
chr21-37066951-37067057,
chr21-37070631-37076219,
chr21-37150896-37151160,
chr21-37152332-37152680,
chr21-37152964-37155737,
chr21-37159050-37159484,
chr21-37161265-37161843,
chr21-37164415-37164605,
chr21-37166246-37167761,
chr21-37169450-37169719,
chr21-37220054-37222105,
chr21-37223873-37226814,
chr21-37227026-37228299,
chr21-37230559-37233254,
chr21-37233610-37234227,
chr21-37234937-37235500,
chr21-37237790-37238115,
chr21-37238740-37239885,
chr21-37240742-37241813,
chr21-37243152-37244419,
chr21-37244628-37245530,
chr21-37248968-37249483,
chr21-37249994-37251771,
chr21-37254108-37254748,
chr21-37256946-37259141,
chr21-37259350-37259929,
chr21-37263577-37265365,
chr21-37265595-37269410,
chr21-37270551-37271438,
chr21-37271793-37272440,
chr21-37337327-37340030,
chr21-37351226-37351559,
chr21-37352423-37352964,
chr21-37356357-37357538,
chr21-37357896-37359418,
chr21-37361494-37361790,
chr21-37362970-37363891,
chr21-37364688-37373796,
chr21-37374041-37376667,
chr21-37376938-37377779,
chr21-37378263-37379058,
chr21-37380008-37381186,
chr21-37383017-37383538,
chr21-37390571-37390871,
chr21-37393746-37394036,
chr21-37396832-37397053,
chr21-37425042-37425459,
chr21-37425733-37426027,
chr21-37427162-37427392,
chr21-37429469-37429659,
chr21-37430297-37430954,
chr21-37431347-37431604,
chr21-37432981-37433186,
chr21-37434876-37436804,
chr21-37437345-37438224,
chr21-37445166-37445721,
chr21-37446433-37447382,
chr21-37447585-37447850,
chr21-37449351-37449653,
chr21-37449911-37451094,
chr21-37451394-37453133,
chr21-37454218-37455770,
chr21-37456526-37456855,
chr21-37457092-37457603,
chr21-37458110-37460942,
chr21-37461967-37464126,
chr21-37465468-37465835,
chr21-37467127-37467422,
chr21-37468225-37468457,
chr21-37468762-37469282,
chr21-37469570-37470153,
chr21-37472439-37473360,
chr21-37474926-37475311,
chr21-37478789-37479291,
chr21-37479637-37479955,
chr21-37483561-37484153,
chr21-37485153-37485383,
chr21-37485921-37486191,
chr21-37489319-37490070,
chr21-37494670-37495794,
chr21-37496386-37498023,
chr21-37498550-37499117,
chr21-37527115-37527716,
chr21-37528156-37530049,
chr21-37530593-37532671,
chr21-37532943-37533875,
chr21-37534435-37535148,
chr21-37535724-37536412,
chr21-37536842-37537164,
chr21-37537415-37537884,
chr21-37538100-37538700,
chr21-37545632-37548152,
chr21-37548403-37549384,
chr21-37549977-37550331,
chr21-37550790-37553366,
chr21-37554097-37555011,
chr21-37555275-37556440,
chr21-37557099-37558213,
chr21-37558729-37559099,
chr21-37560348-37560783,
chr21-37562174-37566445,
chr21-37566898-37567476,
chr21-37567984-37568218,
chr21-37568432-37568753,
chr21-37573339-37573876,
chr21-37574240-37576121,
chr21-37580656-37583729,
chr21-37584556-37585034,
chr21-37586942-37587480,
chr21-37589421-37589947,
chr21-37590163-37590598,
chr21-37590864-37591234,
chr21-37591460-37591738,
chr21-37592031-37593523,
chr21-37593857-37595006,
chr21-37595795-37596355,
chr21-37597055-37597561,
chr21-37598275-37598568,
chr21-37606006-37606950,
chr21-37609003-37609455,
chr21-37614362-37614857,
chr21-37615866-37616245,
chr21-37619546-37620117,
chr21-37620432-37620693,
chr21-37622591-37624114,
chr21-37625250-37626011,
chr21-37626527-37627532,
chr21-37631492-37632217,
chr21-37634872-37635580,
chr21-37636032-37637375,
chr21-37639797-37640540,
chr21-37641601-37643989,
chr21-37644571-37645342,
chr21-37646382-37647083,
chr21-37647564-37648424,
chr21-37649610-37650298,
chr21-37654485-37655372,
chr21-37655751-37657541,
chr21-37658435-37660876,
chr21-37661563-37661865,
chr21-37664785-37665141,
chr21-37665901-37666635,
chr21-37667425-37669249,
chr21-37670538-37671794,
chr21-37673084-37677389,
chr21-37848590-37851352,
chr21-37851997-37852496,
chr21-37854587-37856602,
chr21-37858133-37858424,
chr21-37862475-37863023,
chr21-37863574-37864405,
chr21-37865357-37865570,
chr21-37865868-37866779,
chr21-37868675-37872241,
chr21-37873511-37874441,
chr21-37874747-37875524,
chr21-37904870-37905118,
chr21-37909356-37909603,
chr21-37909892-37910463,
chr21-37913354-37918438,
chr21-37920197-37920610,
chr21-37920872-37921888,
chr21-38120402-38123879,
chr21-38225560-38225841,
chr21-38227309-38230831,
chr21-38231386-38232726,
chr21-38233461-38234215,
chr21-38234603-38235613,
chr21-38236084-38237626,
chr21-38237989-38238652,
chr21-38239700-38242323,
chr21-38242575-38246729,
chr21-38247012-38247257,
chr21-38249205-38250252,
chr21-38250993-38251661,
chr21-38252145-38252348,
chr21-38253333-38253633,
chr21-38255085-38256173,
chr21-38256759-38258229,
chr21-38258446-38259956,
chr21-38260291-38265425,
chr21-38265648-38270119,
chr21-38270636-38271112,
chr21-38271912-38272896,
chr21-38273791-38279650,
-
Co-expression with cohesin genes Rho = 0.6166
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.230
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.885
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: H9-endodermal,IMR-90,MCF-10A,TAMR-MCF7,MB157,DU145,Right-Ventricle,Aorta,K1,hTERT-HME1,Spleen,H1-Mesenchymal,H1-Mesendoderm,Olfactory,MCF-7,HEK293T,SARS-Cov2-olfactory,GM12878,K-562,A-549,HFFc6,PAEC,HeLa-S3,H1-Trophectoderm,SU-DHL-2,H9-hESC,NCI-H1437,Liver,ARPE-19,Germinal-Center-B,Hep-G2,HT-1197,H1-hESC,HT-1376,Motor-Neuron,NaiveB,U-937,BMEC,HUES64,SU-DHL-4,RT-112,Skin-Fibroblast,Left-Ventricle,CC-2551,HFF-hTERT,HAP1,MCF7-FASR
- Related loop:
chr21:34350000-34375000~~chr21:37200000-37225000,
chr21:34350000-34375000~~chr21:37250000-37275000,
chr21:34600000-34625000~~chr21:37250000-37275000,
chr21:36950000-36975000~~chr21:37250000-37275000,
chr21:36975000-37000000~~chr21:37200000-37225000,
chr21:36975000-37000000~~chr21:37225000-37250000,
chr21:36975000-37000000~~chr21:37250000-37275000,
chr21:37050000-37075000~~chr21:37250000-37275000,
chr21:37150000-37175000~~chr21:37250000-37275000,
chr21:37200000-37225000~~chr21:37425000-37450000,
chr21:37200000-37225000~~chr21:37475000-37500000,
chr21:37200000-37225000~~chr21:37525000-37550000,
chr21:37200000-37225000~~chr21:37550000-37575000,
chr21:37200000-37225000~~chr21:37625000-37650000,
chr21:37200000-37225000~~chr21:37650000-37675000,
chr21:37219712-37222158~~chr21:37563130-37566817,
chr21:37219743-37222181~~chr21:37461893-37464011,
chr21:37219743-37222181~~chr21:37581749-37583648,
chr21:37219743-37222181~~chr21:37608243-37609947,
chr21:37219743-37222181~~chr21:37641599-37643616,
chr21:37219750-37222176~~chr21:37364949-37367653,
chr21:37219750-37222176~~chr21:37580199-37581548,
chr21:37219773-37222194~~chr21:37581619-37583704,
chr21:37219804-37222187~~chr21:37581794-37583687,
chr21:37219804-37222187~~chr21:37641615-37643952,
chr21:37219959-37222123~~chr21:37641546-37643999,
chr21:37219960-37222181~~chr21:37641580-37643713,
chr21:37220147-37222181~~chr21:37562857-37565652,
chr21:37220161-37222184~~chr21:37563560-37566497,
chr21:37225000-37250000~~chr21:37425000-37450000,
chr21:37225000-37250000~~chr21:37475000-37500000,
chr21:37225000-37250000~~chr21:37525000-37550000,
chr21:37225000-37250000~~chr21:37550000-37575000,
chr21:37225000-37250000~~chr21:37575000-37600000,
chr21:37225000-37250000~~chr21:37600000-37625000,
chr21:37225000-37250000~~chr21:37625000-37650000,
chr21:37225000-37250000~~chr21:37650000-37675000,
chr21:37225000-37250000~~chr21:37900000-37925000,
chr21:37250000-37275000~~chr21:37350000-37375000,
chr21:37250000-37275000~~chr21:37375000-37400000,
chr21:37250000-37275000~~chr21:37425000-37450000,
chr21:37250000-37275000~~chr21:37450000-37475000,
chr21:37250000-37275000~~chr21:37550000-37575000,
chr21:37250000-37275000~~chr21:37575000-37600000,
chr21:37250000-37275000~~chr21:37625000-37650000,
chr21:37250000-37275000~~chr21:37650000-37675000,
chr21:37250000-37275000~~chr21:37850000-37875000,
chr21:37250000-37275000~~chr21:38225000-38250000,
chr21:37250000-37275000~~chr21:38250000-38275000,
chr21:37256973-37259370~~chr21:37367958-37369182,
chr21:37265872-37268915~~chr21:37357432-37359628,
chr21:37265872-37268915~~chr21:37364916-37367657,
chr21:37266235-37268923~~chr21:37357430-37359645,
chr21:37266235-37268923~~chr21:37364949-37367653,
chr21:37266285-37268905~~chr21:37364989-37367643,
chr21:37266529-37268622~~chr21:37338190-37339892,
chr21:37266529-37268622~~chr21:37364975-37369290,
chr21:37266529-37268622~~chr21:38120549-38122138,
chr21:37267024-37268624~~chr21:37364965-37367685,
chr21:37267054-37268569~~chr21:37365010-37367672,
chr21:37267089-37268595~~chr21:37365079-37366546,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIQWD8ZYD, 4DNFI8649RQJ, GSE87112, 4DNFI3CFMRID, ENCSR662QKG, GSE95015, 4DNFIWZEN3FF, ENCSR194SRI, GSE43070, 4DNFI5CGQ46V, 4DNFIDJ2JZ7Q, 4DNFIMROE6N4, GSE118716, 4DNFIE8E4ANZ, ENCSR499RVD, GSE108787, GSE116869, 4DNFI5SUHCGZ, ENCSR852KQC, GSE84022, GSE120294, ENCSR672RHL, 4DNFIILDWK8M, 4DNFI7H4II2V, 4DNFIW8TIFI5, 4DNFIZ4F74QR, ENCSR410MDC, 4DNFIMEG1QIC, ENCSR478BMT, ENCSR732QOH, 4DNFI6EIFUZI, 4DNFIA6NSSBJ, 4DNFIBM714BP, 4DNFIF2D3TL9, 4DNFIYD8LO9Z, ENCSR668RDP, GSE155380, 4DNFIV239W4L, GSE97394, ENCSR587DSF, GSE80820, 4DNFIE8T8JZ8, 4DNFI1E6NJQJ, ENCSR128RPG, 4DNFISTWNV9C, ENCSR507AHE, GSE52457, ENCSR658RQQ, 4DNFIM2BMJ33, Direct, ENCSR314HAC, 4DNFI6XD6JAQ, 4DNFISPUVQHA, 4DNFIAS8LV1C, 4DNFIX7H3CE2, ENCSR386KHY, 4DNFI1UEG1HD, GSE165038, GSE101921, GSE108869, 4DNFIYIAUEPW, ENCSR244BBG, ENCSR228TUX, ENCSR393LOP, GSE44267, ENCSR991JXX, 4DNFIPAF4PYT, 4DNFIC3HAU11, 4DNFIQVMVRP6, GSE48592, ENCSR110JOO, 4DNFI2J1ODWB, 4DNFIVJ3IIQL, 4DNFIFI6NIKJ, 4DNFIDKJFK2S, ENCSR933UZH, ENCSR833CMG, 4DNFIDBIEXI7, 4DNFIFLJLIS5, 4DNFIZGCA8AH, GSE105028, GSE58752, 4DNFIH7TH4MF, 4DNFII84FBKM
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: HL-60,SLK
- Cohesin-DEGs, number of studies: 3
- Cohesin-DEGs, study: GSE131581,GSE138937
- Cohesin-DEGs, subunit: CTCF,Rad21,SA2