Deatailed information for gene ENSG00000180530
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00014867
- Gene Symbol: NRIP1
- Ensembl ID: ENSG00000180530
-
Gene locus: chr21:14961234-15065000
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-14074982-14076805,
chr21-14078786-14079337,
chr21-14081972-14082588,
chr21-14083193-14085404,
chr21-14086133-14086946,
chr21-14087731-14088065,
chr21-14088528-14088691,
chr21-14092884-14093529,
chr21-14095068-14096724,
chr21-14097913-14098387,
chr21-14241467-14241660,
chr21-14243210-14243271,
chr21-14253316-14254447,
chr21-14257889-14261023,
chr21-14281105-14281959,
chr21-14295215-14295291,
chr21-14296029-14296203,
chr21-14297072-14297309,
chr21-14376765-14377390,
chr21-14378678-14379134,
chr21-14382340-14384384,
chr21-14389947-14390070,
chr21-14402984-14405552,
chr21-14416188-14417646,
chr21-14480065-14481269,
chr21-14481676-14484519,
chr21-14485378-14486503,
chr21-14486972-14489793,
chr21-14493049-14494367,
chr21-14495023-14495539,
chr21-14497768-14500804,
chr21-14524873-14526196,
chr21-14526494-14529969,
chr21-14530357-14536642,
chr21-14537276-14539605,
chr21-14541246-14550672,
chr21-14655397-14655824,
chr21-14659181-14659672,
chr21-14664157-14664393,
chr21-14670561-14671666,
chr21-14672297-14673128,
chr21-14673525-14673970,
chr21-14674191-14674484,
chr21-14674832-14677302,
chr21-14771132-14775232,
chr21-14776599-14776961,
chr21-14777435-14777640,
chr21-14779142-14779611,
chr21-14789081-14789506,
chr21-14850439-14850784,
chr21-14857468-14857884,
chr21-14861730-14867468,
chr21-14868004-14869396,
chr21-14869900-14872963,
chr21-14874201-14874958,
chr21-14875513-14876818,
chr21-14877231-14881713,
chr21-14884719-14885074,
chr21-14886972-14889717,
chr21-14891154-14892018,
chr21-14892252-14892703,
chr21-14897736-14898129,
chr21-14900078-14901068,
chr21-14901294-14901976,
chr21-14906120-14906423,
chr21-14911249-14912416,
chr21-14913610-14913946,
chr21-14916689-14917170,
chr21-14917837-14918085,
chr21-14918481-14918803,
chr21-14920907-14921180,
chr21-14923415-14924002,
chr21-14955906-14957615,
chr21-14957952-14958563,
chr21-14959237-14960295,
chr21-14968863-14969588,
chr21-14977644-14978098,
chr21-14979219-14979633,
chr21-14981349-14981523,
chr21-14984759-14985835,
chr21-14989089-14989683,
chr21-14991983-14992261,
chr21-14994087-14994394,
chr21-14995418-14997309,
chr21-14999736-15000684,
chr21-15001026-15001397,
chr21-15001864-15002263,
chr21-15002856-15007018,
chr21-15007965-15009110,
chr21-15009396-15011542,
chr21-15014507-15017598,
chr21-15019494-15019826,
chr21-15022316-15023068,
chr21-15023450-15024653,
chr21-15028146-15028422,
chr21-15030830-15032347,
chr21-15034118-15034903,
chr21-15043805-15044171,
chr21-15046924-15047559,
chr21-15048398-15048943,
chr21-15050583-15051369,
chr21-15051819-15053037,
chr21-15054708-15055248,
chr21-15057205-15057843,
chr21-15058151-15060232,
chr21-15060514-15067444,
chr21-15069437-15070135,
chr21-15128295-15129126,
chr21-15132673-15133365,
chr21-15134765-15134989,
chr21-15138403-15142164,
chr21-15145594-15146490,
chr21-15149683-15150166,
chr21-15151490-15152324,
chr21-15155413-15155883,
chr21-15159358-15159865,
chr21-15163125-15163429,
chr21-15164026-15164374,
chr21-15164670-15165346,
chr21-15171644-15171827,
chr21-15172374-15174253,
chr21-15175055-15175178,
chr21-15179360-15179660,
chr21-15183865-15184356,
chr21-15190004-15190275,
chr21-15191959-15193168,
chr21-15195617-15196347,
chr21-15198385-15201877,
chr21-15202126-15202457,
chr21-15202662-15205478,
chr21-15206151-15213136,
chr21-15218446-15220810,
chr21-15221520-15223735,
chr21-15223988-15225135,
chr21-15228404-15228465,
chr21-15228934-15229233,
chr21-15229961-15230188,
chr21-15241569-15243035,
chr21-15243421-15243865,
chr21-15244900-15245256,
chr21-15249402-15250141,
chr21-15250379-15250829,
chr21-15252541-15252763,
chr21-15255710-15256444,
chr21-15272182-15272431,
chr21-15276353-15276608,
chr21-15281015-15281332,
chr21-15282742-15283004,
chr21-15289229-15290867,
chr21-15291573-15292301,
chr21-15292906-15293919,
chr21-15295909-15296124,
chr21-15297411-15297584,
chr21-15431069-15431422,
chr21-15432953-15433663,
chr21-15436096-15436440,
chr21-15437922-15438269,
chr21-15440731-15441700,
chr21-15442506-15445840,
chr21-15446197-15446869,
chr21-15448526-15449052,
chr21-15455633-15456680,
chr21-15468364-15468759,
chr21-15470766-15470841,
chr21-15471943-15472539,
chr21-15480544-15485701,
chr21-15486435-15487318,
chr21-15495910-15496512,
chr21-15531804-15532473,
chr21-15534572-15534993,
chr21-15540593-15540691,
chr21-15543487-15544405,
chr21-15547167-15548514,
chr21-15549401-15550208,
chr21-15551801-15554215,
chr21-15566134-15566282,
chr21-15566701-15567087,
chr21-15574421-15574823,
chr21-15585495-15588247,
chr21-15590091-15590381,
chr21-15590652-15594426,
chr21-15596889-15597197,
chr21-15726005-15726347,
chr21-15726744-15727018,
chr21-15728664-15733925,
chr21-15734927-15736334,
chr21-15737261-15737766,
chr21-15741172-15745156,
chr21-15748731-15750124,
chr21-15824259-15827480,
chr21-15827702-15827852,
chr21-15828618-15828901,
chr21-15834852-15835348,
chr21-15837530-15838161,
chr21-15841385-15842641,
chr21-15845569-15846660,
chr21-15848382-15849717,
chr21-16123565-16126016,
chr21-16126245-16126854,
chr21-16132369-16133445,
chr21-16134209-16135228,
chr21-16145469-16146726,
chr21-16149892-16150354,
chr21-16179066-16180618,
chr21-16181053-16181397,
chr21-16182009-16182569,
chr21-16184082-16184512,
chr21-16185564-16186135,
chr21-16186787-16187211,
chr21-16187950-16188513,
chr21-16189420-16189727,
chr21-16192814-16197732,
chr21-16198035-16199514,
chr21-16199967-16200171,
chr21-16275469-16276010,
chr21-16278935-16281446,
chr21-16281661-16282184,
chr21-16282871-16283166,
chr21-16284608-16285086,
chr21-16290319-16290597,
chr21-16291430-16291616,
chr21-16295739-16296369,
chr21-16299142-16299640,
chr21-16549809-16552371,
chr21-16553024-16553429,
chr21-16554422-16555230,
chr21-16555905-16556068,
chr21-16556680-16557811,
chr21-16561687-16562411,
chr21-16563033-16564655,
chr21-16565213-16565671,
chr21-16569553-16572421,
chr21-16572677-16573040,
chr21-16573328-16574192,
chr21-16574890-16574992,
-
Co-expression with cohesin genes Rho = 0.5516
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.352
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.906
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,MB157,DU145,Keratinocytes192627,Aorta,K1,hTERT-HME1,H1-Mesenchymal,H1-Mesendoderm,Olfactory,Hepatocyte-H9,GM19239,HEK293T,MCF-7,GM12891,GM12878,K-562,Naive-hESC,A-549,HFFc6,PAEC,HeLa-S3,LNCaP,H1-Trophectoderm,SU-DHL-2,H9-hESC,KU-19-19,NCI-H1437,iPSC,Liver,ARPE-19,Germinal-Center-B,Hep-G2,HT-1197,Kelly,H1-hESC,HCC1599,GM19238,HT-1376,Motor-Neuron,MSLCL,NaiveB,HUVEC,NPC-H9,RT-112,Skin-Fibroblast,CC-2551,HFF-hTERT
- Related loop:
chr21:14075000-14100000~~chr21:15025000-15050000,
chr21:14225000-14250000~~chr21:14950000-14975000,
chr21:14253183-14254696~~chr21:15062247-15066667,
chr21:14259014-14260613~~chr21:15062794-15066469,
chr21:14275000-14300000~~chr21:14950000-14975000,
chr21:14375000-14400000~~chr21:14950000-14975000,
chr21:14375000-14400000~~chr21:15050000-15075000,
chr21:14400000-14425000~~chr21:15050000-15075000,
chr21:14475000-14500000~~chr21:14950000-14975000,
chr21:14525000-14550000~~chr21:15050000-15075000,
chr21:14650000-14675000~~chr21:14950000-14975000,
chr21:14775000-14800000~~chr21:14950000-14975000,
chr21:14850000-14875000~~chr21:14950000-14975000,
chr21:14850000-14875000~~chr21:14975000-15000000,
chr21:14850000-14875000~~chr21:15025000-15050000,
chr21:14850000-14875000~~chr21:15050000-15075000,
chr21:14862220-14865605~~chr21:15064456-15067091,
chr21:14862240-14865713~~chr21:15062575-15066369,
chr21:14862269-14865635~~chr21:15064553-15067078,
chr21:14862528-14865734~~chr21:15064383-15066714,
chr21:14863074-14865706~~chr21:15062524-15066377,
chr21:14863114-14865715~~chr21:15062247-15066667,
chr21:14863229-14865687~~chr21:15063337-15066739,
chr21:14866302-14867752~~chr21:15062794-15066469,
chr21:14875000-14900000~~chr21:14975000-15000000,
chr21:14875000-14900000~~chr21:15000000-15025000,
chr21:14875000-14900000~~chr21:15025000-15050000,
chr21:14875000-14900000~~chr21:15050000-15075000,
chr21:14878983-14881740~~chr21:15064456-15067091,
chr21:14900000-14925000~~chr21:15050000-15075000,
chr21:14950000-14975000~~chr21:15125000-15150000,
chr21:14950000-14975000~~chr21:15150000-15175000,
chr21:14950000-14975000~~chr21:15250000-15275000,
chr21:14950000-14975000~~chr21:15275000-15300000,
chr21:14950000-14975000~~chr21:15425000-15450000,
chr21:14950000-14975000~~chr21:15450000-15475000,
chr21:14950000-14975000~~chr21:15475000-15500000,
chr21:14950000-14975000~~chr21:15525000-15550000,
chr21:14950000-14975000~~chr21:15575000-15600000,
chr21:14950000-14975000~~chr21:16125000-16150000,
chr21:14975000-15000000~~chr21:15150000-15175000,
chr21:14975000-15000000~~chr21:15175000-15200000,
chr21:14975000-15000000~~chr21:15450000-15475000,
chr21:14975000-15000000~~chr21:15725000-15750000,
chr21:14975000-15000000~~chr21:16175000-16200000,
chr21:14975000-15000000~~chr21:16550000-16575000,
chr21:14975000-15000000~~chr21:21700000-21725000,
chr21:14975000-15000000~~chr21:34500000-34525000,
chr21:14991585-14992812~~chr21:15482170-15484279,
chr21:15000000-15025000~~chr21:16275000-16300000,
chr21:15000000-15025000~~chr21:16550000-16575000,
chr21:15000000-15025000~~chr21:17600000-17625000,
chr21:15015404-15016956~~chr21:15482458-15484489,
chr21:15025000-15050000~~chr21:15200000-15225000,
chr21:15025000-15050000~~chr21:15475000-15500000,
chr21:15025000-15050000~~chr21:17775000-17800000,
chr21:15050000-15075000~~chr21:15200000-15225000,
chr21:15050000-15075000~~chr21:15225000-15250000,
chr21:15050000-15075000~~chr21:15425000-15450000,
chr21:15050000-15075000~~chr21:15475000-15500000,
chr21:15050000-15075000~~chr21:15550000-15575000,
chr21:15050000-15075000~~chr21:15825000-15850000,
chr21:15050098-15051493~~chr21:15482282-15484273,
chr21:15061979-15064702~~chr21:15482166-15484539,
chr21:15061997-15064123~~chr21:15482148-15484288,
chr21:15062023-15063974~~chr21:15482271-15484266,
chr21:15062029-15064015~~chr21:15482133-15484467,
chr21:15062083-15063801~~chr21:15482152-15484193,
chr21:15062090-15064023~~chr21:15482242-15484275,
chr21:15062119-15064171~~chr21:15482181-15484302,
chr21:15062119-15064171~~chr21:15591175-15593440,
chr21:15062123-15064135~~chr21:15482146-15484453,
chr21:15062134-15063397~~chr21:15482511-15484173,
chr21:15062134-15063969~~chr21:15482449-15484099,
chr21:15062139-15064038~~chr21:15482164-15484373,
chr21:15062148-15063986~~chr21:15482191-15484318,
chr21:15062155-15063352~~chr21:15482418-15484201,
chr21:15062160-15063836~~chr21:15482132-15484452,
chr21:15062163-15063910~~chr21:15482170-15484279,
chr21:15062163-15066356~~chr21:15482418-15484253,
chr21:15062187-15063420~~chr21:15482323-15484323,
chr21:15062193-15066426~~chr21:15482133-15484587,
chr21:15062202-15063876~~chr21:15482458-15484489,
chr21:15062205-15066426~~chr21:15482183-15484335,
chr21:15062223-15066649~~chr21:15482380-15484257,
chr21:15062247-15066667~~chr21:15482157-15484375,
chr21:15062524-15066377~~chr21:15482195-15484456,
chr21:15062529-15066349~~chr21:15482321-15484221,
chr21:15062531-15066418~~chr21:15482135-15484281,
chr21:15062541-15063823~~chr21:15482189-15484221,
chr21:15062558-15063934~~chr21:15482105-15484266,
chr21:15062575-15066369~~chr21:15482132-15484427,
chr21:15062585-15066485~~chr21:15482230-15484353,
chr21:15062590-15066457~~chr21:15482560-15484272,
chr21:15062613-15066552~~chr21:15482262-15484309,
chr21:15062794-15066469~~chr21:15482537-15484345,
chr21:15064446-15065859~~chr21:15482105-15484266,
chr21:15064456-15067091~~chr21:15482170-15484279,
chr21:15064511-15066370~~chr21:15482164-15484373,
chr21:15064522-15065940~~chr21:15482543-15484384,
chr21:15064549-15066726~~chr21:15482189-15484221,
chr21:15065167-15066394~~chr21:15482181-15484302,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
GSE43070, 4DNFIDJ2JZ7Q, 4DNFIBN9K4V9, GSE103148, 4DNFI7H4II2V, 4DNFIZ4F74QR, 4DNFIREVU1Z5, ENCSR113OIR, 4DNFI9VXTBE2, 4DNFIRKGMZRQ, ENCSR668RDP, 4DNFICEGAHRC, 4DNFIE8T8JZ8, 4DNFI9YAVTI1, ENCSR299VMZ, 4DNFISPUVQHA, GSE116872, ENCSR305RTT, ENCSR527RXH, GSE105028, ENCSR833CMG, 4DNFI3CFMRID, ENCSR662QKG, GSE94872, GSE118716, ENCSR499RVD, 4DNFIB7QTIMH, ENCSR146FPM, GSE69643, GSE155380, 4DNFICSTCJQZ, ENCSR587DSF, ENCSR452NHL, GSE80820, GSE52457, Direct, ENCSR314HAC, ENCSR479MTN, 4DNFIXWCLD4M, 4DNFIAS8LV1C, 4DNFIX7H3CE2, 4DNFIYIAUEPW, ENCSR244BBG, ENCSR991JXX, 4DNFI9ZWZ5BS, 4DNFI2J1ODWB, 4DNFIVJ3IIQL, 4DNFIFLJLIS5, 4DNFIDBIEXI7, 4DNFIWZEN3FF, ENCSR194SRI, 4DNFIE8E4ANZ, GSE120294, GSE84022, 4DNFIPV5KFMK, ENCSR672RHL, 4DNFIW8TIFI5, ENCSR410MDC, 4DNFIMEG1QIC, ENCSR732QOH, 4DNFIBM714BP, 4DNFIL9M97T2, ENCSR386KHY, ENCSR393LOP, GSE44267, 4DNFIPAF4PYT, ENCSR404HWQ, 4DNFIFI6NIKJ, 4DNFIDKJFK2S, ENCSR933UZH, GSE58752, GSE116869, 4DNFI8649RQJ, 4DNFIMROE6N4, GSE108787, 4DNFI5SUHCGZ, ENCSR866FWQ, 4DNFI6EIFUZI, ENCSR381DCY, ENCSR981FNA, 4DNFIV239W4L, ENCSR752QCX, ENCSR128RPG, 4DNFI1UEG1HD, 4DNFIZF1KI43, 4DNFIC3HAU11, 4DNFIQVMVRP6, ENCSR247RGI, ENCSR110JOO, ENCSR338WUS, 4DNFI5LCW273, 4DNFII84FBKM
- Cohesin-loop subunit: SMC1,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
-
Involved cell types for DEG evidence: SLK,OCI-AML-3,K-562,MCF-10A,Kelly,HeLa-S3,Keratinocytes,CordBlood
- Cohesin-DEGs, number of studies: 13
- Cohesin-DEGs, study: GSE115253,GSE83870,GSE73224,GSE111537,GSE154086,GSE131448,GSE138937,GSE108869,GSE130558
- Cohesin-DEGs, subunit: SMC3,SA2,WAPL,CTCF,Rad21,SMC1,BORIS