Deatailed information for gene ENSG00000142192
Check detailed explainations here
- Basic information
- CohesinDB ID: CDBG00008205
- Gene Symbol: APP
- Ensembl ID: ENSG00000142192
-
Gene locus: chr21:25880550-26171128
Strand: -
- Gene type: protein_coding
- Double-evidenced cohesin related CRMs
- Whether cohesin-related CRMs (double-evidenced): True
- All evidenced type: Interaction,DEGs,
- Regulatory cohesin (double-evidenced):
chr21-24928151-24928482,
chr21-24932663-24932952,
chr21-24940555-24940777,
chr21-25324462-25325130,
chr21-25327956-25328178,
chr21-25328669-25330433,
chr21-25342463-25343340,
chr21-25349180-25349255,
chr21-25349636-25351281,
chr21-25360555-25361481,
chr21-25361740-25362653,
chr21-25368696-25371342,
chr21-25371606-25372243,
chr21-25373228-25373956,
chr21-25399514-25400754,
chr21-25401827-25402550,
chr21-25420705-25426209,
chr21-25572281-25575261,
chr21-25576227-25589346,
chr21-25589610-25591105,
chr21-25591791-25592728,
chr21-25595802-25596358,
chr21-25600851-25601124,
chr21-25606719-25610187,
chr21-25614176-25615182,
chr21-25624549-25624749,
chr21-25626132-25626377,
chr21-25626696-25627327,
chr21-25638808-25641127,
chr21-25642332-25642777,
chr21-25646355-25647152,
chr21-25647707-25648230,
chr21-25750080-25750495,
chr21-25756342-25756628,
chr21-25770235-25770898,
chr21-25778080-25778847,
chr21-25779288-25779695,
chr21-25787871-25788223,
chr21-25788822-25789364,
chr21-25789892-25791705,
chr21-25795113-25795355,
chr21-25850382-25850871,
chr21-25857068-25857674,
chr21-25862118-25863437,
chr21-25865445-25866261,
chr21-25866908-25867564,
chr21-25868924-25869531,
chr21-25871333-25873005,
chr21-25875158-25875785,
chr21-25877272-25877556,
chr21-25878883-25884507,
chr21-25886456-25886884,
chr21-25887111-25887606,
chr21-25887958-25888558,
chr21-25890135-25890660,
chr21-25895168-25897778,
chr21-25898579-25899047,
chr21-25900705-25901071,
chr21-25901581-25901855,
chr21-25903499-25904624,
chr21-25907805-25908312,
chr21-25911994-25912826,
chr21-25914521-25914901,
chr21-25915948-25916381,
chr21-25918328-25919300,
chr21-25925448-25926502,
chr21-25926837-25927155,
chr21-25928018-25928342,
chr21-25930042-25930439,
chr21-25931631-25932182,
chr21-25934006-25935829,
chr21-25936970-25937197,
chr21-25939045-25939712,
chr21-25944844-25945071,
chr21-25948503-25949092,
chr21-25949635-25950151,
chr21-25952178-25952242,
chr21-25953149-25954885,
chr21-25957155-25957888,
chr21-25959897-25962359,
chr21-25962876-25964940,
chr21-25965954-25968091,
chr21-25969014-25969348,
chr21-25970446-25971016,
chr21-25972490-25972729,
chr21-25982956-25984253,
chr21-25986015-25986347,
chr21-25988529-25989413,
chr21-25991403-25991747,
chr21-25992093-25992403,
chr21-25997796-25999512,
chr21-25999972-26000170,
chr21-26000893-26001794,
chr21-26003541-26003718,
chr21-26007390-26008630,
chr21-26008836-26009076,
chr21-26009756-26011796,
chr21-26012489-26013187,
chr21-26014050-26014288,
chr21-26015969-26016331,
chr21-26016609-26017229,
chr21-26019797-26021009,
chr21-26022497-26023913,
chr21-26032239-26032891,
chr21-26038484-26038973,
chr21-26040358-26040769,
chr21-26041367-26042591,
chr21-26044605-26044836,
chr21-26047339-26047601,
chr21-26055116-26056355,
chr21-26057470-26057741,
chr21-26058637-26059126,
chr21-26060627-26060916,
chr21-26061415-26061729,
chr21-26061934-26062607,
chr21-26068005-26069153,
chr21-26070638-26071594,
chr21-26072693-26073278,
chr21-26076786-26077083,
chr21-26077573-26077818,
chr21-26081211-26081885,
chr21-26082626-26082861,
chr21-26084181-26084592,
chr21-26085937-26086198,
chr21-26091586-26092080,
chr21-26093188-26093377,
chr21-26094937-26095373,
chr21-26097068-26098116,
chr21-26099539-26100826,
chr21-26101093-26101372,
chr21-26102155-26102452,
chr21-26106493-26107129,
chr21-26115274-26117937,
chr21-26120863-26121114,
chr21-26122436-26122650,
chr21-26124329-26126589,
chr21-26127536-26128392,
chr21-26133563-26133797,
chr21-26136678-26137258,
chr21-26138612-26139133,
chr21-26139601-26140849,
chr21-26145242-26145601,
chr21-26146681-26147011,
chr21-26147729-26149462,
chr21-26150217-26150652,
chr21-26151334-26152383,
chr21-26153595-26154542,
chr21-26154777-26155253,
chr21-26158881-26159268,
chr21-26159924-26160609,
chr21-26162072-26162427,
chr21-26162939-26163160,
chr21-26163946-26164899,
chr21-26165409-26165563,
chr21-26165938-26172090,
chr21-26172443-26173621,
chr21-26176450-26178042,
chr21-26179380-26179859,
chr21-26181756-26182144,
chr21-26184190-26184559,
chr21-26184891-26185848,
chr21-26189728-26190051,
chr21-26192241-26192738,
chr21-26194214-26195543,
chr21-26196483-26196948,
chr21-26197472-26197568,
chr21-26199145-26200151,
chr21-26252748-26253550,
chr21-26258758-26259007,
chr21-26265323-26265680,
chr21-26269376-26269901,
chr21-26330958-26332551,
chr21-26333724-26334264,
chr21-26341128-26341398,
chr21-26375270-26375569,
chr21-26377212-26377465,
chr21-26385630-26386225,
chr21-26388039-26392190,
chr21-26405129-26407108,
chr21-26408839-26409266,
chr21-26409616-26410188,
chr21-26411556-26411854,
chr21-26412621-26413492,
chr21-26426603-26426761,
chr21-26437290-26438175,
chr21-26439370-26439560,
chr21-26442974-26444624,
chr21-26444843-26446180,
chr21-26446388-26446877,
chr21-26447728-26450082,
chr21-26527113-26527235,
chr21-26529571-26529884,
chr21-26542226-26542363,
chr21-26543512-26543793,
chr21-26545511-26545777,
chr21-26546651-26547189,
chr21-26550230-26550784,
chr21-26554333-26554888,
chr21-26555706-26556025,
chr21-26561447-26561737,
chr21-26562684-26562870,
chr21-26565280-26565546,
chr21-26570205-26570607,
chr21-26572401-26573661,
chr21-26587292-26589031,
chr21-26677932-26678184,
chr21-26681492-26681815,
chr21-26684363-26684507,
chr21-26686016-26686591,
chr21-26690085-26690451,
chr21-26698349-26698770,
chr21-26702109-26702704,
chr21-26709227-26709736,
chr21-26714761-26718662,
chr21-26718980-26720367,
chr21-26721013-26721255,
chr21-26721627-26722108,
chr21-26801063-26801912,
chr21-26805125-26805692,
chr21-26806617-26807296,
chr21-26810912-26811585,
chr21-26814123-26815116,
chr21-26815437-26816621,
chr21-26816961-26817766,
chr21-26819112-26820624,
chr21-26824624-26825033,
chr21-26826754-26827193,
chr21-26832682-26836085,
chr21-26836642-26836862,
chr21-26837135-26838300,
chr21-26839542-26841526,
chr21-26841743-26847812,
chr21-26848196-26852813,
chr21-27502070-27502374,
chr21-27503674-27504028,
chr21-27504825-27506541,
chr21-27508104-27508347,
chr21-27508938-27509630,
chr21-27512883-27513396,
chr21-27513662-27514448,
chr21-27514706-27515096,
chr21-27515839-27516138,
chr21-27519144-27520086,
chr21-27605771-27606779,
chr21-27616203-27616513,
-
Co-expression with cohesin genes Rho = 0.6015
FDR = 0.0000
(Note: Cohesin does not need to 'co-express' with its regulated genes because expression of cohesin genes in conserved. The co-expression only provides addtional information)
- Tissue specificity
-
Gene expression across tissues (TPM):
-
Tissue specificity of gene (Gini-coefficient): 0.251
0:Conserved; 1:Tissue-specific For all genes: quantile-25%: 0.26, quantile-50%: 0.36 'quantile-75%': 0.60
-
Cell Specificity of regulatory cohesin (1:Tissue-specific; 0:Conserved): 0.916
0:Conserved; 1:Tissue-specific. For all cohesin sites: quantile-25%: 0.82, quantile-50%: 0.86 'quantile-75%': 0.90
- Cohesin-loop evidence
- Whether has cohesin-loop: True
-
Involved cell types for loop evidence: IMR-90,MB157,DU145,Keratinocytes192627,Aorta,GM12892,K1,hTERT-HME1,Spleen,H1-Mesenchymal,H1-Mesendoderm,Olfactory,Hepatocyte-H9,GM19239,HEK293T,MCF-7,GM12891,SARS-Cov2-olfactory,GM12878,Pancreas,K-562,A-549,CyT49-pancreatic,HFFc6,PAEC,HeLa-S3,LNCaP,H1-Trophectoderm,SU-DHL-2,H9-hESC,KU-19-19,NCI-H460,NCI-H1437,iPSC,Liver,ARPE-19,HCT-116,REC-1,Hep-G2,HT-1197,Kelly,H1-hESC,HCC1599,GM19238,HT-1376,Motor-Neuron,MSLCL,NaiveB,BMEC,HUES64,SU-DHL-4,HUVEC,NPC-H9,CyT49-endoderm,RT-112,Skin-Fibroblast,Left-Ventricle,CC-2551,HFF-hTERT,HAP1,MCF7-FASR
- Related loop:
chr21:24925000-24950000~~chr21:26150000-26175000,
chr21:25325000-25350000~~chr21:26125000-26150000,
chr21:25350000-25375000~~chr21:26150000-26175000,
chr21:25400000-25425000~~chr21:26150000-26175000,
chr21:25575000-25600000~~chr21:26150000-26175000,
chr21:25575000-25600000~~chr21:26175000-26200000,
chr21:25600000-25625000~~chr21:25875000-25900000,
chr21:25600000-25625000~~chr21:25975000-26000000,
chr21:25600000-25625000~~chr21:26000000-26025000,
chr21:25600000-25625000~~chr21:26075000-26100000,
chr21:25600000-25625000~~chr21:26150000-26175000,
chr21:25600000-25625000~~chr21:26175000-26200000,
chr21:25606813-25609539~~chr21:26168567-26171752,
chr21:25606813-25609564~~chr21:26168596-26171705,
chr21:25606914-25609560~~chr21:26000712-26002239,
chr21:25625000-25650000~~chr21:26150000-26175000,
chr21:25750000-25775000~~chr21:25950000-25975000,
chr21:25750000-25775000~~chr21:26150000-26175000,
chr21:25775000-25800000~~chr21:25950000-25975000,
chr21:25775000-25800000~~chr21:26150000-26175000,
chr21:25789502-25791503~~chr21:26168596-26171705,
chr21:25789567-25791545~~chr21:26168542-26171800,
chr21:25850000-25875000~~chr21:26175000-26200000,
chr21:25875000-25900000~~chr21:25975000-26000000,
chr21:25875000-25900000~~chr21:26050000-26075000,
chr21:25875000-25900000~~chr21:26150000-26175000,
chr21:25875000-25900000~~chr21:26175000-26200000,
chr21:25875000-25900000~~chr21:26325000-26350000,
chr21:25875000-25900000~~chr21:26375000-26400000,
chr21:25875000-25900000~~chr21:26400000-26425000,
chr21:25875000-25900000~~chr21:26525000-26550000,
chr21:25875000-25900000~~chr21:26675000-26700000,
chr21:25875000-25900000~~chr21:26700000-26725000,
chr21:25875000-25900000~~chr21:26825000-26850000,
chr21:25875000-25900000~~chr21:28725000-28750000,
chr21:25880592-25882759~~chr21:26168595-26171726,
chr21:25880592-25882759~~chr21:26715468-26718051,
chr21:25880643-25882866~~chr21:26000836-26002126,
chr21:25880643-25882866~~chr21:26169947-26171806,
chr21:25880643-25882866~~chr21:26715421-26718120,
chr21:25880719-25882754~~chr21:26168603-26171485,
chr21:25880719-25882754~~chr21:26716644-26718024,
chr21:25880755-25882952~~chr21:26168541-26171786,
chr21:25880755-25882952~~chr21:26715348-26718310,
chr21:25880758-25882873~~chr21:26715355-26718381,
chr21:25880762-25882939~~chr21:26168567-26172542,
chr21:25880762-25882939~~chr21:26715356-26718205,
chr21:25880770-25883137~~chr21:26168491-26171741,
chr21:25880770-25883137~~chr21:26715200-26718356,
chr21:25880785-25882961~~chr21:26168597-26171877,
chr21:25880785-25882961~~chr21:26715447-26718081,
chr21:25880794-25882895~~chr21:26168600-26171765,
chr21:25880794-25882895~~chr21:26715448-26718086,
chr21:25880795-25883103~~chr21:26168579-26171699,
chr21:25880795-25883103~~chr21:26714832-26718268,
chr21:25880802-25883195~~chr21:26715193-26718542,
chr21:25880806-25883113~~chr21:26168567-26171752,
chr21:25880806-25883113~~chr21:26715204-26718284,
chr21:25880813-25882766~~chr21:26170075-26171770,
chr21:25880813-25882766~~chr21:26715409-26718024,
chr21:25880821-25883172~~chr21:26168566-26171735,
chr21:25880821-25883172~~chr21:26715280-26718256,
chr21:25880823-25883149~~chr21:26587219-26589182,
chr21:25880823-25883149~~chr21:26715242-26718467,
chr21:25880831-25882882~~chr21:26168509-26171714,
chr21:25880831-25882882~~chr21:26715317-26718206,
chr21:25880833-25882973~~chr21:25999508-26002814,
chr21:25880833-25882973~~chr21:26715347-26718278,
chr21:25880854-25882845~~chr21:26170145-26171780,
chr21:25880871-25883139~~chr21:26168536-26171703,
chr21:25880871-25883139~~chr21:26715160-26718522,
chr21:25880873-25883193~~chr21:26715252-26718261,
chr21:25880878-25883186~~chr21:26000596-26002821,
chr21:25880878-25883186~~chr21:26031390-26033174,
chr21:25880878-25883186~~chr21:26169836-26171640,
chr21:25880878-25883186~~chr21:26715477-26718366,
chr21:25880879-25883157~~chr21:25999375-26002832,
chr21:25880879-25883157~~chr21:26715196-26718405,
chr21:25880888-25882763~~chr21:26000649-26002298,
chr21:25880911-25882804~~chr21:26715538-26718232,
chr21:25880913-25882748~~chr21:26169335-26171730,
chr21:25880921-25883079~~chr21:26715396-26718303,
chr21:25880943-25882795~~chr21:26715485-26718222,
chr21:25880959-25882727~~chr21:26168566-26171728,
chr21:25881104-25882779~~chr21:26715351-26718059,
chr21:25881105-25882920~~chr21:26168579-26171721,
chr21:25881130-25882858~~chr21:26715239-26718238,
chr21:25886689-25887960~~chr21:26168542-26171691,
chr21:25886700-25888011~~chr21:26715421-26718120,
chr21:25886797-25887944~~chr21:26715196-26718405,
chr21:25894856-25897119~~chr21:26168541-26171786,
chr21:25894856-25897119~~chr21:26715348-26718310,
chr21:25894872-25896862~~chr21:25999375-26002832,
chr21:25894872-25896862~~chr21:26715196-26718405,
chr21:25895002-25896873~~chr21:26168572-26171752,
chr21:25895048-25897116~~chr21:26168461-26171694,
chr21:25895048-25897116~~chr21:26715193-26718542,
chr21:25895093-25897256~~chr21:26000596-26002821,
chr21:25895093-25897256~~chr21:26031390-26033174,
chr21:25895093-25897256~~chr21:26715477-26718366,
chr21:25895098-25896866~~chr21:26715200-26718356,
chr21:25895145-25896737~~chr21:26169947-26171806,
chr21:25895145-25896737~~chr21:26715421-26718120,
chr21:25895157-25897132~~chr21:26715317-26718206,
chr21:25895183-25896791~~chr21:26168600-26171765,
chr21:25895184-25896718~~chr21:25999508-26002814,
chr21:25895184-25896849~~chr21:26168597-26171877,
chr21:25895184-25896849~~chr21:26715447-26718081,
chr21:25895199-25896667~~chr21:26170075-26171770,
chr21:25895223-25896749~~chr21:26170145-26171780,
chr21:25895288-25896659~~chr21:26031859-26033130,
chr21:25924913-25927132~~chr21:25962734-25964839,
chr21:25925000-25950000~~chr21:26150000-26175000,
chr21:25925000-25950000~~chr21:27600000-27625000,
chr21:25934144-25935653~~chr21:25983458-25984620,
chr21:25934208-25935715~~chr21:25953103-25954588,
chr21:25950000-25975000~~chr21:26050000-26075000,
chr21:25950000-25975000~~chr21:26075000-26100000,
chr21:25950000-25975000~~chr21:26125000-26150000,
chr21:25950000-25975000~~chr21:26150000-26175000,
chr21:25950000-25975000~~chr21:26250000-26275000,
chr21:25950000-25975000~~chr21:26375000-26400000,
chr21:25950000-25975000~~chr21:26525000-26550000,
chr21:25950000-25975000~~chr21:26800000-26825000,
chr21:25975000-26000000~~chr21:26100000-26125000,
chr21:25975000-26000000~~chr21:26150000-26175000,
chr21:26000000-26025000~~chr21:26325000-26350000,
chr21:26000000-26025000~~chr21:26700000-26725000,
chr21:26010694-26012200~~chr21:26715347-26718278,
chr21:26010769-26012247~~chr21:26715196-26718405,
chr21:26025000-26050000~~chr21:26125000-26150000,
chr21:26025000-26050000~~chr21:26150000-26175000,
chr21:26031848-26033090~~chr21:26168677-26171722,
chr21:26050000-26075000~~chr21:26150000-26175000,
chr21:26050000-26075000~~chr21:26375000-26400000,
chr21:26050000-26075000~~chr21:26525000-26550000,
chr21:26075000-26100000~~chr21:26700000-26725000,
chr21:26075000-26100000~~chr21:28425000-28450000,
chr21:26125000-26150000~~chr21:26675000-26700000,
chr21:26150000-26175000~~chr21:26325000-26350000,
chr21:26150000-26175000~~chr21:26375000-26400000,
chr21:26150000-26175000~~chr21:26425000-26450000,
chr21:26150000-26175000~~chr21:26525000-26550000,
chr21:26150000-26175000~~chr21:26550000-26575000,
chr21:26150000-26175000~~chr21:26700000-26725000,
chr21:26150000-26175000~~chr21:26800000-26825000,
chr21:26150000-26175000~~chr21:26825000-26850000,
chr21:26150000-26175000~~chr21:27500000-27525000,
chr21:26168536-26171703~~chr21:26715160-26718522,
chr21:26168542-26171691~~chr21:26714717-26718289,
chr21:26168542-26171800~~chr21:26715396-26718303,
chr21:26168566-26171735~~chr21:26715280-26718256,
chr21:26168567-26172542~~chr21:26715356-26718205,
chr21:26168579-26171721~~chr21:26714841-26717171,
chr21:26168586-26171752~~chr21:26715190-26718539,
chr21:26168591-26172572~~chr21:26715252-26718261,
chr21:26175000-26200000~~chr21:26375000-26400000,
chr21:26175000-26200000~~chr21:26675000-26700000,
chr21:26175000-26200000~~chr21:26700000-26725000,
chr21:26175000-26200000~~chr21:27500000-27525000,
chr21:26175000-26200000~~chr21:28725000-28750000,
chr21:26175000-26200000~~chr21:29075000-29100000,
- Cohesin-loop type: HiChIP,HiC,Direct,ChIAPET
- Cohesin-loop study:
4DNFIQYQWPF5, GSE95015, GSE43070, 4DNFIDJ2JZ7Q, 4DNFITUOMFUQ, ENCSR794RDS, 4DNFIBN9K4V9, ENCSR852KQC, GSE103148, 4DNFI7H4II2V, 4DNFIZ4F74QR, 4DNFIEYQ5ZIR, 4DNFIREVU1Z5, 4DNFIA6NSSBJ, ENCSR113OIR, 4DNFI9VXTBE2, 4DNFIRKGMZRQ, ENCSR668RDP, GSE97394, 4DNFICEGAHRC, 4DNFI1E6NJQJ, 4DNFI9YAVTI1, ENCSR658RQQ, ENCSR299VMZ, 4DNFI6XD6JAQ, 4DNFISPUVQHA, 4DNFIK61ILGM, GSE116872, 4DNFIAWVDQ8C, ENCSR305RTT, ENCSR527RXH, GSE105028, ENCSR833CMG, 4DNFIBKZK63V, ENCSR033GUP, 4DNFIQWD8ZYD, GSE87112, 4DNFI3CFMRID, ENCSR662QKG, GSE94872, GSE118716, ENCSR499RVD, 4DNFIB7QTIMH, 4DNFIBXWIH8J, 4DNFIJWBWE41, 4DNFICSTCJQZ, GSE155380, ENCSR587DSF, ENCSR452NHL, 4DNFIIMZB6Y9, GSE80820, GSE52457, Direct, ENCSR314HAC, ENCSR479MTN, 4DNFIX7H3CE2, 4DNFIYIAUEPW, ENCSR244BBG, ENCSR991JXX, 4DNFI9815EEJ, 4DNFI9ZWZ5BS, 4DNFI2J1ODWB, 4DNFIVJ3IIQL, 4DNFIFLJLIS5, 4DNFIDBIEXI7, 4DNFIDZT7PR8, 4DNFIS5F6EBL, 4DNFIZGCA8AH, 4DNFIH7TH4MF, 4DNFIWZEN3FF, ENCSR194SRI, 4DNFI5CGQ46V, 4DNFIE8E4ANZ, GSE120294, GSE84022, 4DNFIPV5KFMK, ENCSR672RHL, 4DNFIW8TIFI5, ENCSR410MDC, 4DNFIMEG1QIC, ENCSR732QOH, 4DNFIBM714BP, 4DNFIF2D3TL9, 4DNFIYD8LO9Z, ENCSR123UVP, 4DNFIL9M97T2, ENCSR550JLK, 4DNFI3A3VYWU, 4DNFIM2BMJ33, 4DNFIYDBBSE3, ENCSR386KHY, 4DNFIEJEFCAM, ENCSR393LOP, GSE44267, 4DNFIPAF4PYT, GSE48592, ENCSR255XYX, ENCSR404HWQ, 4DNFIJ8JKKWJ, 4DNFIFI6NIKJ, ENCSR933UZH, ENCSR094EIC, GSE58752, ENCSR507AHE, GSE116869, 4DNFI8649RQJ, GSE116875, 4DNFIMROE6N4, GSE108787, 4DNFI5SUHCGZ, ENCSR545YBD, ENCSR489OCU, 4DNFI6EIFUZI, ENCSR866FWQ, 4DNFII6AN691, ENCSR381DCY, ENCSR981FNA, 4DNFIV239W4L, ENCSR752QCX, ENCSR128RPG, 4DNFI6JJQKFJ, 4DNFI1UEG1HD, ENCSR228TUX, 4DNFIOCW5AEM, 4DNFIQVMVRP6, 4DNFIC3HAU11, ENCSR247RGI, ENCSR110JOO, ENCSR338WUS, 4DNFI5LCW273, 4DNFII84FBKM, 4DNFIVSCH2CH
- Cohesin-loop subunit: SMC1,CTCF,Other,Rad21
- Cohesin-DEGs evidence
- Whether cohesin DEGs: True
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Involved cell types for DEG evidence: MCF-7,HL-60,SLK,P3HR-1,MCF-10A,U2OS,HeLa-S3
- Cohesin-DEGs, number of studies: 9
- Cohesin-DEGs, study: GSE140651,GSE177045,GSE101921,GSE131581,GSE154086,GSE138937,GSE89799,GSE130558
- Cohesin-DEGs, subunit: SA2,WAPL,CTCF,SMC1,Rad21